dbPTM

CAN9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CAN9_HUMAN
UniProt AC	O14815
Protein Name	Calpain-9
Gene Name	CAPN9
Organism	Homo sapiens (Human).
Sequence Length	690
Subcellular Localization
Protein Description	Calcium-regulated non-lysosomal thiol-protease..
Protein Sequence	MPYLYRAPGPQAHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWMAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDKDEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHLTMNI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
170	Phosphorylation	ADHNEFWSALLEKAY CCHHHHHHHHHHHHH	17.85	26074081
177	Phosphorylation	SALLEKAYAKLNGSY HHHHHHHHHHHCCCH	18.48	26074081
183	Phosphorylation	AYAKLNGSYEALKGG HHHHHCCCHHHHCCC	20.80	26074081
184	Phosphorylation	YAKLNGSYEALKGGS HHHHCCCHHHHCCCC	13.45	26074081
191	Phosphorylation	YEALKGGSAIEAMED HHHHCCCCHHHHHHH	34.44	26074081
200	Phosphorylation	IEAMEDFTGGVAETF HHHHHHHCCCHHHHC	45.40	18767875
228	Phosphorylation	EKALKRGSLLGCFID HHHHHHCCEEEEEEC	25.18	-
362	Phosphorylation	QGSWVRGSTAGGCRN CCCEEECCCCCCCHH	12.43	27273156
423	Phosphorylation	LTIGYAIYECPDKDE EEEEEEEEECCCCCC	11.87	24719451
446	Phosphorylation	YHASRARSKTFINLR HHHHHHHCCCEEEHH	34.75	23312004
448	Phosphorylation	ASRARSKTFINLREV HHHHHCCCEEEHHHC	30.87	23312004
562	Phosphorylation	DIKFKKLSLISCKNI CCCCCEEEEEEECCC	32.32	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CAN9_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CAN9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CAN9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
MPI_HUMAN	MPI	physical	26344197

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CAN9_HUMAN

Related Literatures of Post-Translational Modification