CAN2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAN2_RAT
• UniProt AC: Q07009
• Protein Name: Calpain-2 catalytic subunit
• Gene Name: Capn2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 700
• Subcellular Localization: Cytoplasm. Cell membrane. Translocates to the plasma membrane upon Ca(2+) binding..
• Protein Description: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs..
• Protein Sequence: MAGIAMKLAKDREAAEGLGSHERAIKYLNQDYETLRNECLEAGALFQDPSFPALPSSLGFKELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLDQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELRKPPPNLFKIIQKALEKGSLLGCSIDITSAADSEAVTYQKLVKGHAYSVTGAEEVESSGSLQKLIRIRNPWGQVEWTGKWNDNCPSWNTVDPEVRANLTERQEDGEFWMSFSDFLRHYSRLEICNLTPDTLTCDSYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDDEDGERGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELTGQTNIHLSKNFFLTTRARERSDTFINLREVLNRFKLPPGEYVLVPSTFEPHKNGDFCIRVFSEKKADYQTVDDEIEANIEEIEANEEDIGDGFRRLFAQLAGEDAEISAFELQTILRRVLAKREDIKSDGFSIETCKIMVDMLDEDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKLPCQLHQVIVARFADDELIIDFDNFVRCLVRLEILFKIFKQLDPENTGTIQLDLISWLSFSVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGIAMKLA ------CCCHHHHHH	20.35	-
7	Acetylation	-MAGIAMKLAKDREA -CCCHHHHHHHHHHH	35.95	22902405
280	Acetylation	ESSGSLQKLIRIRNP CCCCCCEEEEEEECC	51.69	22902405
301	S-nitrosocysteine	TGKWNDNCPSWNTVD CCCCCCCCCCCCCCC	2.93	-
301	S-nitrosylation	TGKWNDNCPSWNTVD CCCCCCCCCCCCCCC	2.93	22178444
462	Phosphorylation	TTRARERSDTFINLR EECHHHCCCCEECHH	35.93	30181290
464	Phosphorylation	RARERSDTFINLREV CHHHCCCCEECHHHH	27.88	30181290
609	Acetylation	TKIQKYQKIYREIDV HHHHHHHHHHHHCCC	38.32	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAN2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAN2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAN2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CPEB3_HUMAN	CPEB3	physical	22711986
P53_HUMAN	TP53	physical	22711986

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.