CAMK1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAMK1_ARATH
• UniProt AC: O80673
• Protein Name: CDPK-related kinase 1
• Gene Name: CRK1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 576
• Subcellular Localization: Membrane; Lipid-anchor; Cytoplasmic side.
• Protein Description: May play a role in signal transduction pathways that involve calcium as a second messenger (By similarity). Serine/threonine kinase that phosphorylates histone H3. Confers thermotolerance; involved in the heat-shock-mediated calmodulin-dependent signal transduction leading to the activation of heat-shock transcription factors (HSFs); phosphorylates HSFA1A..
• Protein Sequence: MGICHGKPVEQQSKSLPVSGETNEAPTNSQPPAKSSGFPFYSPSPVPSLFKSSPSVSSSVSSTPLRIFKRPFPPPSPAKHIRAFLARRYGSVKPNEVSIPEGKECEIGLDKSFGFSKQFASHYEIDGEVGRGHFGYTCSAKGKKGSLKGQEVAVKVIPKSKMTTAIAIEDVSREVKMLRALTGHKNLVQFYDAFEDDENVYIVMELCKGGELLDKILQRGGKYSEDDAKKVMVQILSVVAYCHLQGVVHRDLKPENFLFSTKDETSPLKAIDFGLSDYVKPDERLNDIVGSAYYVAPEVLHRTYGTEADMWSIGVIAYILLCGSRPFWARTESGIFRAVLKAEPNFEEAPWPSLSPEAVDFVKRLLNKDYRKRLTAAQALCHPWLVGSHELKIPSDMIIYKLVKVYIMSTSLRKSALAALAKTLTVPQLAYLREQFTLLGPSKNGYISMQNYKTAILKSSTDAMKDSRVFDFVHMISCLQYKKLDFEEFCASALSVYQLEAMETWEQHARRAYELFEKDGNRPIMIEELASELGLGPSVPVHVVLQDWIRHSDGKLSFLGFVRLLHGVSSRTLQKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGICHGKPV ------CCCCCCCCC		-
15	Phosphorylation	PVEQQSKSLPVSGET CCCCCCCCCCCCCCC		25561503
19	Phosphorylation	QSKSLPVSGETNEAP CCCCCCCCCCCCCCC		25561503
35	Phosphorylation	NSQPPAKSSGFPFYS CCCCCCHHCCCCCCC		30407730
36	Phosphorylation	SQPPAKSSGFPFYSP CCCCCHHCCCCCCCC		30407730
41	Phosphorylation	KSSGFPFYSPSPVPS HHCCCCCCCCCCCCC		30407730
42	Phosphorylation	SSGFPFYSPSPVPSL HCCCCCCCCCCCCCH		30407730
44	Phosphorylation	GFPFYSPSPVPSLFK CCCCCCCCCCCCHHC		30407730
48	Phosphorylation	YSPSPVPSLFKSSPS CCCCCCCCHHCCCCC		30407730
52	Phosphorylation	PVPSLFKSSPSVSSS CCCCHHCCCCCCCCC		17317660
53	Phosphorylation	VPSLFKSSPSVSSSV CCCHHCCCCCCCCCC		17317660
55	Phosphorylation	SLFKSSPSVSSSVSS CHHCCCCCCCCCCCC		19376835
57	Phosphorylation	FKSSPSVSSSVSSTP HCCCCCCCCCCCCCC		19376835
58	Phosphorylation	KSSPSVSSSVSSTPL CCCCCCCCCCCCCCC		19376835
59	Phosphorylation	SSPSVSSSVSSTPLR CCCCCCCCCCCCCCE		19376835
61	Phosphorylation	PSVSSSVSSTPLRIF CCCCCCCCCCCCEEE		19376835
62	Phosphorylation	SVSSSVSSTPLRIFK CCCCCCCCCCCEEEC		19376835
63	Phosphorylation	VSSSVSSTPLRIFKR CCCCCCCCCCEEECC		19376835
76	Phosphorylation	KRPFPPPSPAKHIRA CCCCCCCCHHHHHHH		23111157
163	Phosphorylation	VIPKSKMTTAIAIED EECHHHCEEEEEHHH		27532006
164	Phosphorylation	IPKSKMTTAIAIEDV ECHHHCEEEEEHHHH		27532006
291	Phosphorylation	RLNDIVGSAYYVAPE HHHHHCCCHHHCCHH		-
331	Phosphorylation	SRPFWARTESGIFRA CCCCEECCHHCHHHH		15308754
333	Phosphorylation	PFWARTESGIFRAVL CCEECCHHCHHHHHH		30291188
557	Phosphorylation	RHSDGKLSFLGFVRL HCCCCCEEHHHHHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
333	S	Phosphorylation	Kinase	CPK1	Q06850	Uniprot
333	S	Phosphorylation	Kinase	CPK34	Q3E9C0	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAMK1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAMK1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HFA1A_ARATH	HSF1	physical	18466301

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.