CALI_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CALI_HUMAN
• UniProt AC: Q13939
• Protein Name: Calicin
• Gene Name: CCIN
• Organism: Homo sapiens (Human).
• Sequence Length: 588
• Subcellular Localization: Cytoplasm, cytoskeleton, perinuclear theca, calyx. Sperm head cytoskeletal structure tightly associated to the nucleus.
• Protein Description: Possible morphogenetic cytoskeletal element in spermiogenic differentiation..
• Protein Sequence: MKLEFTEKNYNSFVLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSNDMKTADELFITIDTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDFLIKSICRANCLRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGRLLRDENLHVLNEDQALSALINWVYFRKEDREKYFKKFFNYINLNAVSNKTLVFASNKLVGMENTSSHTTLIESVLMDRKQERPCSLLVYQRKGALLDSVVILGGQKAHGQFNDGVFAYIIQENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVWCLAGKMSIPMDGTAVITKGDRHLYIVTGRCLVKGYISRVGVVDCFDTSTGDVVQCITFPIEFNHRPLLSFQQDNILCVHSHRQSVEINLQKVKASKTTTSVPVLPNSCPLDVSHAICSIGDSKVFVCGGVTTASDVQTKDYTINPNAFLLDQKTGKWKTLAPPPEALDCPACCLAKLPCKILQRI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	FTEKNYNSFVLQNLN ECCHHHHHHHHHHHC	13.33	25693802
58	Phosphorylation	PLVRSLISSNDMKTA HHHHHHHCCCCCCCC	28.51	30622161
59	Phosphorylation	LVRSLISSNDMKTAD HHHHHHCCCCCCCCC	29.83	30622161
63	Acetylation	LISSNDMKTADELFI HHCCCCCCCCCEEEE	43.34	12437807
97	Phosphorylation	YSGKVVISEQNVEEL HCCCEEECCCCHHHH	22.86	30622161
149	Phosphorylation	LFELKEVSDVAYSGI HHHCEECCCCCCCCC	27.71	29759185
153	Phosphorylation	KEVSDVAYSGIRDNF EECCCCCCCCCCCCC	13.79	29759185
154	Phosphorylation	EVSDVAYSGIRDNFH ECCCCCCCCCCCCCE	20.29	29759185
162	Phosphorylation	GIRDNFHYWASPEGS CCCCCCEEEECCCCC	9.87	25693802
165	Phosphorylation	DNFHYWASPEGSMHF CCCEEEECCCCCEEE	14.88	25693802
169	Phosphorylation	YWASPEGSMHFMRCP EEECCCCCEEEECCC	13.86	25693802
222	Phosphorylation	YFKKFFNYINLNAVS HHHHHHHHCCHHCCC	5.99	-
246	Phosphorylation	KLVGMENTSSHTTLI CEECCCCCCCCCHHH	20.50	25693802
247	Phosphorylation	LVGMENTSSHTTLIE EECCCCCCCCCHHHH	31.53	30622161
248	Phosphorylation	VGMENTSSHTTLIES ECCCCCCCCCHHHHH	23.86	30622161
250	Phosphorylation	MENTSSHTTLIESVL CCCCCCCCHHHHHHH	25.83	30622161
251	Phosphorylation	ENTSSHTTLIESVLM CCCCCCCHHHHHHHC	21.95	25693802
280	Phosphorylation	RKGALLDSVVILGGQ CCCCCCCEEEEECCC	20.46	30622161
328	Phosphorylation	SATSAGRYIYISGGT HCCCCCCEEEEECCC	9.36	22461510
330	Phosphorylation	TSAGRYIYISGGTTE CCCCCEEEEECCCHH	4.70	22461510
332	Phosphorylation	AGRYIYISGGTTEQI CCCEEEEECCCHHEE	17.75	22461510
348	Phosphorylation	GLKTAWRYDMDDNSW CCEEEEEEECCCCCC	12.62	-
354	Phosphorylation	RYDMDDNSWTKLPDL EEECCCCCCCCCCCC	43.02	30622161
356	Phosphorylation	DMDDNSWTKLPDLPI ECCCCCCCCCCCCCC	23.64	30622161
383	Phosphorylation	TVYSVGGSIAPRRYV EEEECCCEECCCCHH	15.06	24719451
396	Phosphorylation	YVSNIYRYDERKEVW HHCCEEECCCCCEEE	12.75	29759185
410	Phosphorylation	WCLAGKMSIPMDGTA EEEEECEECCCCCCE	27.33	30622161
416	Phosphorylation	MSIPMDGTAVITKGD EECCCCCCEEEECCC	17.31	30622161
500	Phosphorylation	QKVKASKTTTSVPVL EEECCCCCCCCCCCC	32.58	30622161
501	Phosphorylation	KVKASKTTTSVPVLP EECCCCCCCCCCCCC	22.32	30622161
502	Phosphorylation	VKASKTTTSVPVLPN ECCCCCCCCCCCCCC	32.72	30622161
503	Phosphorylation	KASKTTTSVPVLPNS CCCCCCCCCCCCCCC	23.49	30622161
510	Phosphorylation	SVPVLPNSCPLDVSH CCCCCCCCCCCCCCE	18.38	30622161
525	Phosphorylation	AICSIGDSKVFVCGG EEECCCCCEEEEECC	26.04	30622161
534	Phosphorylation	VFVCGGVTTASDVQT EEEECCEEECHHHCC	21.66	25693802
535	Phosphorylation	FVCGGVTTASDVQTK EEECCEEECHHHCCC	23.04	30622161
537	Phosphorylation	CGGVTTASDVQTKDY ECCEEECHHHCCCCC	35.90	30622161
541	Phosphorylation	TTASDVQTKDYTINP EECHHHCCCCCEECC	26.23	25693802

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CALI_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CALI_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CALI_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.