CAH4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAH4_HUMAN
• UniProt AC: P22748
• Protein Name: Carbonic anhydrase 4
• Gene Name: CA4
• Organism: Homo sapiens (Human).
• Sequence Length: 312
• Subcellular Localization: Cell membrane; Lipid-anchor, GPI-anchor.
• Protein Description: Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid..
• Protein Sequence: MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
80	Phosphorylation	SGYDKKQTWTVQNNG ECCCCCCEEEEEECC	31.79	22817900
82	Phosphorylation	YDKKQTWTVQNNGHS CCCCCEEEEEECCEE	18.66	22817900
89	Phosphorylation	TVQNNGHSVMMLLEN EEEECCEEEEEEEEC	17.07	22817900
196	Phosphorylation	NIPKPEMSTTMAESS CCCCHHHCCHHHHHH	21.04	20068231
197	Phosphorylation	IPKPEMSTTMAESSL CCCHHHCCHHHHHHH	21.20	20068231
198	Phosphorylation	PKPEMSTTMAESSLL CCHHHCCHHHHHHHH	13.69	20068231
202	Phosphorylation	MSTTMAESSLLDLLP HCCHHHHHHHHHHCC	19.42	20068231
203	Phosphorylation	STTMAESSLLDLLPK CCHHHHHHHHHHCCH	25.18	20068231
284	GPI-anchor	GQRTVIKSGAPGRPL CCCEEEECCCCCCCC	29.12	7625839

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAH4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAH4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAH4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRDX2_HUMAN	PRDX2	physical	21988832
PIHD1_HUMAN	PIH1D1	physical	21988832
FL2D_HUMAN	WTAP	physical	26071132
CDK18_HUMAN	CDK18	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00527: Retinitis pigmentosa (RP)
• OMIM Disease
• 600852: Retinitis pigmentosa 17 (RP17)
• Kegg Drug
• D00218: Acetazolamide (JP16/USP/INN); Diamox (TN)
• D00219: Acetohexamide (JP16/USP/INN); Dymelor (TN)
• D00518: Diclofenamide (JP16/INN); Dichlorphenamide (USP); Daranide (TN)
• D00652: Brinzolamide (JAN/USP/INN); Azopt (TN)
• D00653: Dorzolamide hydrochloride (JP16/USP); Trusopt (TN)
• D00655: Methazolamide (JAN/USP/INN); Neptazane (TN)
• D01196: Acetazolamide sodium (JAN); Diamox (TN)
• D01822: Clofenamide (JAN/INN)
• D02441: Ethoxzolamide; Cardrase (TN)
• D03845: Sezolamide hydrochloride (USAN)
• D07871: Dorzolamide (INN); Trusopt (TN)
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

GPI-anchor

"Carbonic anhydrase IV: role of removal of C-terminal domain inglycosylphosphatidylinositol anchoring and realization of enzymeactivity.";
Okuyama T., Waheed A., Kusumoto W., Zhu X.L., Sly W.S.;
Arch. Biochem. Biophys. 320:315-322(1995).
Cited for: GPI-ANCHOR AT SER-284, AND MUTAGENESIS OF SER-284.
PubMed: 7625839