CADH9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CADH9_HUMAN
• UniProt AC: Q9ULB4
• Protein Name: Cadherin-9
• Gene Name: CDH9
• Organism: Homo sapiens (Human).
• Sequence Length: 789
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types..
• Protein Sequence: MRTYHYIPLFIWTYMFHTVDTILLQEKPNSYLSSKKIAGLTKDDGKMLRRTKRGWMWNQFFLLEEYTGTDTQYVGKLHTDQDKGDGNLKYILTGDGAGSLFVIDENTGDIHAAKKLDREEKSLYILRAKAIDRKTGRQVEPESEFIIKIHDINDNEPKFTKDLYTASVPEMSGVGTSVIQVTATDADDANYGNSAKVVYSILQGQPYFSVDPESGIIKTALPDMSRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNNNPPRFPQSTYQFNSPESVPLGTHLGRIKANDPDVGENAEMEYSIAEGDGADMFDVITDKDTQEGIITVKQNLDFENQMLYTLRVDASNTHPDPRFLHLGPFKDTAVVKISVEDIDEPPVFTKVSYLIEVDEDVKEGSIIGQVTAYDPDARNNLIKYSVDRHTDMDRIFGIHSENGSIFTLKALDRESSPWHNITVTATEINNPKQSSHIPVFIRILDINDHAPEFAMYYETFVCENAKPGQLIQTVSVMDKDDPPRGHKFFFEPVPEFTLNPNFTIVDNKDNTAGIMTRKDGYSRNKMSTYLLPILIFDNDYPIQSSTGTLTIRVCACDNQGNMQSCTAEALILSAGLSTGALVAILLCVLILLILVVLFAALKRQRKKEPLIISKDDVRDNIVTYNDEGGGEEDTQAFDIGTLRNPEAREDSKLRRDVMPETIFQIRRTVPLWENIDVQDFIHRRLKENDADPSAPPYDSLATYAYEGNDSIADSLSSLESLTADCNQDYDYLSDWGPRFKKLADMYGGDDSDRD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MRTYHYIPLF -----CCCCCCCCHH	17.22	25002506
4	Phosphorylation	----MRTYHYIPLFI ----CCCCCCCCHHH	5.14	25002506
6	Phosphorylation	--MRTYHYIPLFIWT --CCCCCCCCHHHHH	8.20	25002506
13	Phosphorylation	YIPLFIWTYMFHTVD CCCHHHHHHHHCCHH	10.57	25002506
14	Phosphorylation	IPLFIWTYMFHTVDT CCHHHHHHHHCCHHH	5.25	25002506
18	Phosphorylation	IWTYMFHTVDTILLQ HHHHHHCCHHHHHHC	14.60	25002506
21	Phosphorylation	YMFHTVDTILLQEKP HHHCCHHHHHHCCCC	14.80	25002506
30	Phosphorylation	LLQEKPNSYLSSKKI HHCCCCCCCCCCCCC	35.66	24043423
31	Phosphorylation	LQEKPNSYLSSKKIA HCCCCCCCCCCCCCC	19.76	24043423
33	Phosphorylation	EKPNSYLSSKKIAGL CCCCCCCCCCCCCCE	31.70	24043423
34	Phosphorylation	KPNSYLSSKKIAGLT CCCCCCCCCCCCCEE	35.06	24043423
46	2-Hydroxyisobutyrylation	GLTKDDGKMLRRTKR CEECCCCCCHHHHCC	41.58	-
93	Phosphorylation	GNLKYILTGDGAGSL CCEEEEEECCCCCEE	24.54	-
99	Phosphorylation	LTGDGAGSLFVIDEN EECCCCCEEEEEECC	20.35	-
107	Phosphorylation	LFVIDENTGDIHAAK EEEEECCCCCCCHHH	33.90	-
122	Phosphorylation	KLDREEKSLYILRAK CCCHHHHHHHHEEHH	29.68	19413330
164	Phosphorylation	PKFTKDLYTASVPEM CCCCCCEEECCCCCC	15.47	23532336
191	Phosphorylation	TDADDANYGNSAKVV CCCCCCCCCCCHHHH	21.29	23532336
255	N-linked_Glycosylation	LSGTTTVNITLTDVN CCCCEEEEEEEEECC	21.31	UniProtKB CARBOHYD
343	Phosphorylation	DFENQMLYTLRVDAS CCCCCEEEEEEEECC	9.82	-
344	Phosphorylation	FENQMLYTLRVDASN CCCCEEEEEEEECCC	12.25	24719451
387	Phosphorylation	PPVFTKVSYLIEVDE CCEEEEEEEEEEECC	18.77	-
388	Phosphorylation	PVFTKVSYLIEVDED CEEEEEEEEEEECCC	18.06	-
419	Phosphorylation	ARNNLIKYSVDRHTD CCCCEEEEECCCCCC	13.61	24719451
420	Phosphorylation	RNNLIKYSVDRHTDM CCCEEEEECCCCCCH	16.73	24719451
437	N-linked_Glycosylation	IFGIHSENGSIFTLK EEEEEECCCCEEEEE	53.15	UniProtKB CARBOHYD
455	N-linked_Glycosylation	RESSPWHNITVTATE CCCCCCCCEEEEEEE	27.97	UniProtKB CARBOHYD
536	N-linked_Glycosylation	PEFTLNPNFTIVDNK CCCCCCCCCEEEECC	45.69	UniProtKB CARBOHYD
560	Ubiquitination	KDGYSRNKMSTYLLP CCCCCCCCCCCCEEE	32.87	-
648	Phosphorylation	KKEPLIISKDDVRDN CCCCCEEECHHHCCC	24.04	22199227
781	Phosphorylation	FKKLADMYGGDDSDR HHHHHHHHCCCCCCC	20.64	-
786	Phosphorylation	DMYGGDDSDRD---- HHHCCCCCCCC----	39.01	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CADH9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CADH9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CADH9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MEOX2_HUMAN	MEOX2	physical	24722188

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.