CAD16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAD16_HUMAN
• UniProt AC: O75309
• Protein Name: Cadherin-16
• Gene Name: CDH16
• Organism: Homo sapiens (Human).
• Sequence Length: 829
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types..
• Protein Sequence: MVPAWLWLLCVSVPQALPKAQPAELSVEVPENYGGNFPLYLTKLPLPREGAEGQIVLSGDSGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIHLAENLKVLYPHHMAQVHWSGGDVHYHLESHPPGPFEVNAEGNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKLVGPGPGPGATATVTVLVERVMPPPKLDQESYEASVPISAPAGSFLLTIQPSDPISRTLRFSLVNDSEGWLCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLSASAPLVIHFLKAPPAPALTLAPVPSQYLCTPRQDHGLIVSGPSKDPDLASGHGPYSFTLGPNPTVQRDWRLQTLNGSHAYLTLALHWVEPREHIIPVVVSHNAQMWQLLVRVIVCRCNVEGQCMRKVGRMKGMPTKLSAVGILVGTLVAIGIFLILIFTHWTMSRKKDPDQPADSVPLKATV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	O-linked_Glycosylation	SGDSGKATEGPFAMD ECCCCCCCCCCCCCC	44.98	OGP
161	Phosphorylation	DEPGTANSDLRFHIL CCCCCCCCCEEEEEE	35.24	-
192	Phosphorylation	RLGALALSPKGSTSL CCEEEEECCCCCCCH	20.96	24719451
197	Phosphorylation	ALSPKGSTSLDHALE EECCCCCCCHHHHHH	41.81	21130716
198	Phosphorylation	LSPKGSTSLDHALER ECCCCCCCHHHHHHH	33.23	21130716
517	N-linked_Glycosylation	VRLRLCKNLSYEAAP EEEEEECCCCCCCCC	32.97	UniProtKB CARBOHYD
519	Phosphorylation	LRLCKNLSYEAAPSH EEEECCCCCCCCCCC	30.25	-
534	Phosphorylation	EVVVVVQSVAKLVGP EEEEEEEEEHHHHCC	16.66	-
602	N-linked_Glycosylation	TLRFSLVNDSEGWLC EEEEEEEECCCCEEE	53.00	UniProtKB CARBOHYD
666	O-linked_Glycosylation	APPAPALTLAPVPSQ CCCCCCEEECCCCCC	23.99	OGP
687	Phosphorylation	QDHGLIVSGPSKDPD CCCCEEEECCCCCCC	37.68	24043423
690	Phosphorylation	GLIVSGPSKDPDLAS CEEEECCCCCCCCCC	53.89	24043423
705	O-linked_Glycosylation	GHGPYSFTLGPNPTV CCCCCEEECCCCCCC	25.51	OGP
722	N-linked_Glycosylation	DWRLQTLNGSHAYLT CEEEEECCCCCEEEE	53.99	UniProtKB CARBOHYD
782	Phosphorylation	GRMKGMPTKLSAVGI CCCCCCCCHHHHHHH	35.41	22210691
806	Phosphorylation	IFLILIFTHWTMSRK HHHHHHHHHHHHHCC	14.98	-
809	Phosphorylation	ILIFTHWTMSRKKDP HHHHHHHHHHCCCCC	9.54	-
811	Phosphorylation	IFTHWTMSRKKDPDQ HHHHHHHHCCCCCCC	33.31	22210691
822	Phosphorylation	DPDQPADSVPLKATV CCCCCCCCCCCCCCC	27.95	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAD16_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAD16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAD16_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CRYAB_HUMAN	CRYAB	physical	18343407
G6PC_HUMAN	G6PC	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.