CABP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CABP2_HUMAN
• UniProt AC: Q9NPB3
• Protein Name: Calcium-binding protein 2
• Gene Name: CABP2
• Organism: Homo sapiens (Human).
• Sequence Length: 220
• Subcellular Localization: Cytoplasm, perinuclear region . Cell membrane ; Lipid-anchor ; Cytoplasmic side . Golgi apparatus .
• Protein Description: Required for sound encoding at inner hair cells (IHCs) synapses, likely via inhibition of the inactivation of voltage-gated calcium channel of type 1.3 (Cav1.3) in the IHCs. [PubMed: 28183797 Required for the normal transfer of light signals through the retina (By similarity]
• Protein Sequence: MGNCAKRPWRRGPKDPLQWLGSPPRGSCPSPSSSPKEQGDPAPGVQGYSVLNSLVGPACIFLRPSIAATQLDRELRPEEIEELQVAFQEFDRDRDGYIGCRELGACMRTLGYMPTEMELIEISQQISGGKVDFEDFVELMGPKLLAETADMIGVRELRDAFREFDTNGDGRISVGELRAALKALLGERLSQREVDEILQDVDLNGDGLVDFEEFVRMMSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGNCAKRPW ------CCCCCCCCC	37.61	-
2	Myristoylation	------MGNCAKRPW ------CCCCCCCCC	37.61	10625670

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CABP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CABP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CABP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCC2G_RAT	Camk2g	physical	10625670

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614899: Deafness, autosomal recessive, 93 (DFNB93)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Myristoylation

"Five members of a novel Ca(2+)-binding protein (CABP) subfamily withsimilarity to calmodulin.";
Haeseleer F., Sokal I., Verlinde C.L.M.J., Erdjument-Bromage H.,Tempst P., Pronin A.N., Benovic J.L., Fariss R.N., Palczewski K.;
J. Biol. Chem. 275:1247-1260(2000).
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS L-CABP2 ANDS-CABP2), VARIANT GLN-94, AND MYRISTOYLATION AT GLY-2.
PubMed: 10625670