KCC2G_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCC2G_RAT
• UniProt AC: P11730
• Protein Name: Calcium/calmodulin-dependent protein kinase type II subunit gamma
• Gene Name: Camk2g
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 527
• Subcellular Localization: Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side .
• Protein Description: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning (By similarity)..
• Protein Sequence: MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGRQSSAPASPAASAAGLAGQAAKSLLNKKSDGGVKKRKSSSSVHLMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	CTRFTDDYQLFEELG CCCCCCCHHHHHHHC	15.21	-
22	Acetylation	QLFEELGKGAFSVVR HHHHHHCCCHHHHHH	60.74	72627803
22	Ubiquitination	QLFEELGKGAFSVVR HHHHHHCCCHHHHHH	60.74	-
26	Phosphorylation	ELGKGAFSVVRRCVK HHCCCHHHHHHHHCC	21.11	25403869
37	Phosphorylation	RCVKKTSTQEYAAKI HHCCCCCCHHHHHHH	30.56	25403869
43	Ubiquitination	STQEYAAKIINTKKL CCHHHHHHHHCCCCC	35.63	-
48	Ubiquitination	AAKIINTKKLSARDH HHHHHCCCCCCHHHH	47.42	-
49	Ubiquitination	AKIINTKKLSARDHQ HHHHCCCCCCHHHHH	45.71	-
57	Ubiquitination	LSARDHQKLEREARI CCHHHHHHHHHHHHH	49.23	-
57	Acetylation	LSARDHQKLEREARI CCHHHHHHHHHHHHH	49.23	72607925
69	Ubiquitination	ARICRLLKHPNIVRL HHHHHHHCCCCEEEE	62.70	-
69	Acetylation	ARICRLLKHPNIVRL HHHHHHHCCCCEEEE	62.70	7768489
107	Phosphorylation	EDIVAREYYSEADAS HHHHHHHHHCHHHHH	13.51	-
138	Ubiquitination	DIVHRDLKPENLLLA CCCCCCCCHHHHHHH	55.35	-
138	Acetylation	DIVHRDLKPENLLLA CCCCCCCCHHHHHHH	55.35	22902405
146	Phosphorylation	PENLLLASKCKGAAV HHHHHHHHCCCCCCC	38.26	27097102
147	Ubiquitination	ENLLLASKCKGAAVK HHHHHHHCCCCCCCH	34.07	-
149	Ubiquitination	LLLASKCKGAAVKLA HHHHHCCCCCCCHHH	56.15	-
154	Ubiquitination	KCKGAAVKLADFGLA CCCCCCCHHHHHCEE	32.98	-
182	Phosphorylation	AGTPGYLSPEVLRKD CCCCCCCCHHHHHCC	15.55	30181290
223	Phosphorylation	DEDQHKLYQQIKAGA CHHHHHHHHHHHHCC	11.81	-
227	Ubiquitination	HKLYQQIKAGAYDFP HHHHHHHHHCCCCCC	36.11	-
227	Acetylation	HKLYQQIKAGAYDFP HHHHHHHHHCCCCCC	36.11	134807
231	Phosphorylation	QQIKAGAYDFPSPEW HHHHHCCCCCCCCCH	19.73	-
235	Phosphorylation	AGAYDFPSPEWDTVT HCCCCCCCCCHHCCC	35.13	28551015
240	Phosphorylation	FPSPEWDTVTPEAKN CCCCCHHCCCHHHHH	27.61	-
242	Phosphorylation	SPEWDTVTPEAKNLI CCCHHCCCHHHHHHH	19.94	-
246	Ubiquitination	DTVTPEAKNLINQML HCCCHHHHHHHHHHH	51.10	-
254	Phosphorylation	NLINQMLTINPAKRI HHHHHHHCCCHHHCC	17.23	27097102
259	Ubiquitination	MLTINPAKRITADQA HHCCCHHHCCCHHHH	45.66	-
259	Acetylation	MLTINPAKRITADQA HHCCCHHHCCCHHHH	45.66	22902405
268	Ubiquitination	ITADQALKHPWVCQR CCHHHHHCCCCHHCH	51.11	-
276	Phosphorylation	HPWVCQRSTVASMMH CCCHHCHHHHHHHHH	11.01	30411139
277	Phosphorylation	PWVCQRSTVASMMHR CCHHCHHHHHHHHHH	23.45	27097102
280	Phosphorylation	CQRSTVASMMHRQET HCHHHHHHHHHHHHH	16.59	27097102
287	Phosphorylation	SMMHRQETVECLRKF HHHHHHHHHHHHHHH	17.17	29779826
306	Phosphorylation	KLKGAILTTMLVSRN HHHHHHHHHHHHCCC	12.21	-
307	Phosphorylation	LKGAILTTMLVSRNF HHHHHHHHHHHCCCC	12.69	-
311	Phosphorylation	ILTTMLVSRNFSVGR HHHHHHHCCCCCCCC	19.97	27097102
315 (in isoform 3)	Phosphorylation	-	27.49	28432305
315	Phosphorylation	MLVSRNFSVGRQSSA HHHCCCCCCCCCCCC	27.49	28551015
315 (in isoform 2)	Phosphorylation	-	27.49	28432305
319 (in isoform 2)	Phosphorylation	-	35.49	28432305
319 (in isoform 3)	Phosphorylation	-	35.49	28432305
320	Phosphorylation	NFSVGRQSSAPASPA CCCCCCCCCCCCCHH	27.40	23298284
321	Phosphorylation	FSVGRQSSAPASPAA CCCCCCCCCCCCHHH	29.90	23298284
325 (in isoform 3)	Phosphorylation	-	17.64	28432305
325	Phosphorylation	RQSSAPASPAASAAG CCCCCCCCHHHHHHH	17.64	27097102
329	Phosphorylation	APASPAASAAGLAGQ CCCCHHHHHHHHHHH	22.28	27097102
334 (in isoform 3)	Phosphorylation	-	13.72	28432305
335 (in isoform 3)	Phosphorylation	-	23.78	28432305
339	Ubiquitination	GLAGQAAKSLLNKKS HHHHHHHHHHHHHCC	44.65	-
340	Phosphorylation	LAGQAAKSLLNKKSD HHHHHHHHHHHHCCC	33.10	30181290
341 (in isoform 3)	Phosphorylation	-	6.35	25575281
347 (in isoform 3)	Phosphorylation	-	67.74	25575281
348 (in isoform 3)	Phosphorylation	-	50.30	25575281
350 (in isoform 3)	Phosphorylation	-	8.92	25575281
353 (in isoform 3)	Phosphorylation	-	38.07	25575281
354 (in isoform 3)	Phosphorylation	-	64.67	25575281
355 (in isoform 3)	Phosphorylation	-	39.21	25575281
355	Phosphorylation	GGVKKRKSSSSVHLM CCCCCCCCCCCEEEC	39.21	25403869
356	Phosphorylation	GVKKRKSSSSVHLME CCCCCCCCCCEEECC	29.66	22673903
357	Phosphorylation	VKKRKSSSSVHLMEP CCCCCCCCCEEECCC	43.39	22673903
358	Phosphorylation	KKRKSSSSVHLMEPQ CCCCCCCCEEECCCC	18.59	25403869
366	Phosphorylation	VHLMEPQTTVVHNAT EEECCCCEEEEEECC	32.07	27097102
367	Phosphorylation	HLMEPQTTVVHNATD EECCCCEEEEEECCC	18.45	27097102
373	Phosphorylation	TTVVHNATDGIKGST EEEEEECCCCCCCCC	39.82	27097102
379	Phosphorylation	ATDGIKGSTESCNTT CCCCCCCCCCCCCCC	24.81	27097102
380	Phosphorylation	TDGIKGSTESCNTTT CCCCCCCCCCCCCCC	40.35	27097102
382	Phosphorylation	GIKGSTESCNTTTED CCCCCCCCCCCCCCC	16.86	27097102
385	Phosphorylation	GSTESCNTTTEDEDL CCCCCCCCCCCCCCH	39.15	28551015
386	Phosphorylation	STESCNTTTEDEDLK CCCCCCCCCCCCCHH	17.75	27097102
387	Phosphorylation	TESCNTTTEDEDLKV CCCCCCCCCCCCHHH	39.13	28551015
453	Phosphorylation	FYFENLLSKNSKPIH HHHHHHHCCCCCCCE	32.72	22673903
457	Ubiquitination	NLLSKNSKPIHTTIL HHHCCCCCCCEEEEC	58.34	-
486	Phosphorylation	AYIRLTQYIDGQGRP HHHHHHHEECCCCCC	8.85	-
495	Phosphorylation	DGQGRPRTSQSEETR CCCCCCCCCCCCCCE	33.53	25403869
496	Phosphorylation	GQGRPRTSQSEETRV CCCCCCCCCCCCCEE	32.75	25403869
498	Phosphorylation	GRPRTSQSEETRVWH CCCCCCCCCCCEEEE	36.85	25403869
501	Phosphorylation	RTSQSEETRVWHRRD CCCCCCCCEEEEECC	26.86	25403869

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCC2G_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
287	T	Phosphorylation	Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin.	-
287	T	Phosphorylation	Phosphorylation of Thr-287 locks the kinase into an activated state (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCC2G_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of KCC2G_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.