C2CD2_HUMAN - dbPTM
C2CD2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID C2CD2_HUMAN
UniProt AC Q9Y426
Protein Name C2 domain-containing protein 2
Gene Name C2CD2
Organism Homo sapiens (Human).
Sequence Length 696
Subcellular Localization Membrane
Single-pass membrane protein .
Protein Description
Protein Sequence MAMARLGSWLGEAQWLALVSLFVAALATVGLYLAQWALARARPQPQRRAVEPGEGPRPGSDALLSWILTLGSWRSQWQAAWVTALNEEAERKGGPPFLSFEEDPRQQALELVVQEVSSVLRSAEEKVVVCHVVGQAIQFLVSETPALGAGCRLYDMRLSPFHLQLEFHMKEKREDLQISWSFISVPEMAVNIQPKALGEDQVAETSAMSDVLKDILKHLAGSASPSVVLITKPTTVKEAQNLQCAASTAQESCPPKPPRAHELKLLVRNIHVLLLSEPGASGHINAVCVVQLNDPVQRFSSTLTKNTPDLMWEEEFTFELNAKSKELHLQISEAGRSSEGLLATATVPLDLFKKQPSGPQSFTLTSGSACGSSVLGSVTAEFSYMEPGELKSWPIPPPVPAAKIEKDRTVMPCGTVVTTVTAVKTKPRVDVGRASPLSSDSPVKTPIKVKVIEKDISVQAIACRSAPVSKTLSSSDTELLVLNGSDPVAEVAIRQLSESSKLKLKSPRKKSTIIISGISKTSLSQDHDAALMQGYTASVDSTHQEDAPSHPERAAASAPPEEAESAQASLAPKPQEDELDSWDLEKEPQAAAWSSQVLLDPDGDELSESSMSVLEPGTAKKHKGGILRKGAKLFFRRRHQQKDPGMSQSHNDLVFLEQPEGSRRKGITLTRILNKKLLSRHRNKNTMNGAPVEPCT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
58UbiquitinationEPGEGPRPGSDALLS
CCCCCCCCCHHHHHH		29967540
60PhosphorylationGEGPRPGSDALLSWI
CCCCCCCHHHHHHHH		-
118PhosphorylationLVVQEVSSVLRSAEE
HHHHHHHHHHHCCHH		-
154PhosphorylationLGAGCRLYDMRLSPF
CCCCCEEEECCCCHH		29083192
159PhosphorylationRLYDMRLSPFHLQLE
EEEECCCCHHEEEEE		29083192
213UbiquitinationSAMSDVLKDILKHLA
HHHHHHHHHHHHHHC		29967540
409PhosphorylationAKIEKDRTVMPCGTV
HHCCCCCEEEECCEE		29116813
415PhosphorylationRTVMPCGTVVTTVTA
CEEEECCEEEEEEEE		29116813
419PhosphorylationPCGTVVTTVTAVKTK
ECCEEEEEEEECCCC		29116813
425PhosphorylationTTVTAVKTKPRVDVG
EEEEECCCCCCCCCC		29116813
435PhosphorylationRVDVGRASPLSSDSP
CCCCCCCCCCCCCCC		25159151
438PhosphorylationVGRASPLSSDSPVKT
CCCCCCCCCCCCCCC		28176443
439PhosphorylationGRASPLSSDSPVKTP
CCCCCCCCCCCCCCC		28176443
441PhosphorylationASPLSSDSPVKTPIK
CCCCCCCCCCCCCEE		30278072
445PhosphorylationSSDSPVKTPIKVKVI
CCCCCCCCCEEEEEE		25159151
457PhosphorylationKVIEKDISVQAIACR
EEEECCCEEEEEEEE		28348404
471PhosphorylationRSAPVSKTLSSSDTE
ECCCCCCCCCCCCCE		22199227
473PhosphorylationAPVSKTLSSSDTELL
CCCCCCCCCCCCEEE		22199227
474PhosphorylationPVSKTLSSSDTELLV
CCCCCCCCCCCEEEE		26657352
475PhosphorylationVSKTLSSSDTELLVL
CCCCCCCCCCEEEEE		26657352
477PhosphorylationKTLSSSDTELLVLNG
CCCCCCCCEEEEEEC		30278072
497PhosphorylationEVAIRQLSESSKLKL
HHHHHHHCHHCCCCC		24719451
499PhosphorylationAIRQLSESSKLKLKS
HHHHHCHHCCCCCCC		23312004
506PhosphorylationSSKLKLKSPRKKSTI
HCCCCCCCCCCCCEE		24719451
511PhosphorylationLKSPRKKSTIIISGI
CCCCCCCCEEEEECC		23927012
512PhosphorylationKSPRKKSTIIISGIS
CCCCCCCEEEEECCC		23927012
516PhosphorylationKKSTIIISGISKTSL
CCCEEEEECCCCCCC		30243723
519PhosphorylationTIIISGISKTSLSQD
EEEEECCCCCCCCCC		28355574
521PhosphorylationIISGISKTSLSQDHD
EEECCCCCCCCCCHH		26657352
522PhosphorylationISGISKTSLSQDHDA
EECCCCCCCCCCHHH		28348404
524PhosphorylationGISKTSLSQDHDAAL
CCCCCCCCCCHHHHH		25002506
535PhosphorylationDAALMQGYTASVDST
HHHHHCCCEEECCCC		27642862
536PhosphorylationAALMQGYTASVDSTH
HHHHCCCEEECCCCC		25002506
538PhosphorylationLMQGYTASVDSTHQE
HHCCCEEECCCCCCC		25002506
541PhosphorylationGYTASVDSTHQEDAP
CCEEECCCCCCCCCC		25002506
542PhosphorylationYTASVDSTHQEDAPS
CEEECCCCCCCCCCC		25002506
569PhosphorylationEAESAQASLAPKPQE
HHHHHHHHCCCCCCC		28102081
581PhosphorylationPQEDELDSWDLEKEP
CCCCCCCCCCCCCCH		30576142
607PhosphorylationDPDGDELSESSMSVL
CCCCCCCCHHHCCCC		28348404
609PhosphorylationDGDELSESSMSVLEP
CCCCCCHHHCCCCCC		28348404
610PhosphorylationGDELSESSMSVLEPG
CCCCCHHHCCCCCCC		28348404
612PhosphorylationELSESSMSVLEPGTA
CCCHHHCCCCCCCCC		28348404
618PhosphorylationMSVLEPGTAKKHKGG
CCCCCCCCCCCCCCC		-
647PhosphorylationQQKDPGMSQSHNDLV
CCCCCCCCCCCCCEE		29255136
649PhosphorylationKDPGMSQSHNDLVFL
CCCCCCCCCCCEEEE		29255136
662PhosphorylationFLEQPEGSRRKGITL
EEECCCCCCCCCCCH		28555341
668PhosphorylationGSRRKGITLTRILNK
CCCCCCCCHHHHHCH		23312004
670PhosphorylationRRKGITLTRILNKKL
CCCCCCHHHHHCHHH		-
675AcetylationTLTRILNKKLLSRHR
CHHHHHCHHHHHHHC		164321
676AcetylationLTRILNKKLLSRHRN
HHHHHCHHHHHHHCC		164325
679PhosphorylationILNKKLLSRHRNKNT
HHCHHHHHHHCCCCC		-
686PhosphorylationSRHRNKNTMNGAPVE
HHHCCCCCCCCCCCC		-
696PhosphorylationGAPVEPCT-------
CCCCCCCC-------		25159151
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of C2CD2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of C2CD2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of C2CD2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DC1L2_HUMANDYNC1LI2physical
26186194
RHG10_HUMANARHGAP10physical
26186194
S14L1_HUMANSEC14L1physical
26186194
RHG26_HUMANARHGAP26physical
26186194
RHG26_HUMANARHGAP26physical
28514442
RHG10_HUMANARHGAP10physical
28514442
S14L1_HUMANSEC14L1physical
28514442
DC1L2_HUMANDYNC1LI2physical
28514442
DC1L1_HUMANDYNC1LI1physical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of C2CD2_HUMAN

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Related Literatures of Post-Translational Modification

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