BORA_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BORA_DROME
• UniProt AC: Q9VVR2
• Protein Name: Protein aurora borealis
• Gene Name: bora
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 539
• Subcellular Localization: Cytoplasm . Nucleus . Shuttles between the cytoplasm and the nucleus. In interphase cells, it is nuclear. Upon entry into mitosis, it is excluded from the nucleus and translocates into the cytoplasm in a Cdk1-dependent manner.
• Protein Description: Required for the activation of Aurora-A (aur) at the onset of mitosis..
• Protein Sequence: MYNDEVRTPQALKNRYITNVNGLKCRARRNSHSNSSNSSAASATPTNGGKENGKYSPQMSGNVCTPPPKRLHKVRNPFEGAMADRLHLPLIASPSLFRSRTPQLSSTQFEWNIDEVSQLKPADVEPHETQFHDSPDPEQESKAQLAISAFFKESLIVPSPVDCPLRKQRIILNCSEDNTPISNKSRRMRDCEVQTELTLPPILPKALEDALRPYFQPHLAGRLSGRSKSSGGPDIFNSSMRRKLFDLHNVIVLGEQDTAEPSRSMVGSSPQGKQTMFAGRLSDSASGESSFGCLSPIRNLCGLPPGTPDNGTCSGKRKLLMHELELPSPIAPSEHLSRRLVHSKVEISVTEQHDTLSERTALKFTPDRSSSPMGGGLEHSDCSINQRVRRLRVNSTRQVVIETGDQPLFEETEGEEEEAESEDDEEADAMQLSTVSFNCSSSNSDTPRGHKRHRSAQRKNLSQSFSANLEEEADQTQGGAGSIQPAEPPSVAMPQQGARIPLYRADSGFNETSSTTFAFSQDLPLDVSMACCSTPSTRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	KCRARRNSHSNSSNS EEEHHCCCCCCCCCC	26.87	21082442
33	Phosphorylation	RARRNSHSNSSNSSA EHHCCCCCCCCCCCC	37.92	21082442
179	Phosphorylation	LNCSEDNTPISNKSR EECCCCCCCCCCCCH	34.03	25749252
264	Phosphorylation	DTAEPSRSMVGSSPQ CCCCCCHHHCCCCCC	23.35	25749252
328	Phosphorylation	MHELELPSPIAPSEH EEEECCCCCCCCCHH	41.38	21082442
383	Phosphorylation	GLEHSDCSINQRVRR CCCCCCCCHHHHHHH	29.57	18327897

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BORA_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BORA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BORA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DYL1_DROME	ctp	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-383, AND MASSSPECTROMETRY.
PubMed: 18327897