BOP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BOP_HUMAN
• UniProt AC: Q7L3V2
• Protein Name: Protein Bop {ECO:0000303|PubMed:23055042}
• Gene Name: RTL10 {ECO:0000312|HGNC:HGNC:26112}
• Organism: Homo sapiens (Human).
• Sequence Length: 364
• Subcellular Localization: Mitochondrion .
• Protein Description: Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity..
• Protein Sequence: MPRGRCRQQGPRIPIWAAANYANAHPWQQMDKASPGVAYTPLVDPWIERPCCGDTVCVRTTMEQKSTASGTCGGKPAERGPLAGHMPSSRPHRVDFCWVPGSDPGTFDGSPWLLDRFLAQLGDYMSFHFEHYQDNISRVCEILRRLTGRAQAWAAPYLDGDLPLPDDYELFCQDLKEVVQDPNSFAEYHAVVTCPLPLASSQLPVAPQLPVVRQYLARFLEGLALDMGTAPRSLPAAMATPAVSGSNSVSRSALFEQQLTKESTPGPKEPPVLPSSTCSSKPGPVEPASSQPEEAAPTPVPRLSESANPPAQRPDPAHPGGPKPQKTEEEVLETEGDQEVSLGTPQEVVEAPETPGEPPLSPGF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	PIWAAANYANAHPWQ CEEHHHCCCCCCHHH		27642862
34	Phosphorylation	WQQMDKASPGVAYTP HHHHCCCCCCCEECC		25159151
39	Phosphorylation	KASPGVAYTPLVDPW CCCCCCEECCCCCCC		27642862
65	Ubiquitination	VRTTMEQKSTASGTC EECCCCCCCCCCCCC		-
71	Phosphorylation	QKSTASGTCGGKPAE CCCCCCCCCCCCCCC		22210691
89	Phosphorylation	LAGHMPSSRPHRVDF CCCCCCCCCCCCCEE		22210691
233	Phosphorylation	DMGTAPRSLPAAMAT CCCCCCCCCCHHHCC		28555341
252	Phosphorylation	GSNSVSRSALFEQQL CCCCCCHHHHHHHHH		29449344
260	Phosphorylation	ALFEQQLTKESTPGP HHHHHHHCCCCCCCC		29449344
276	Phosphorylation	EPPVLPSSTCSSKPG CCCCCCCCCCCCCCC		26657352
277	Phosphorylation	PPVLPSSTCSSKPGP CCCCCCCCCCCCCCC		26657352
290	Phosphorylation	GPVEPASSQPEEAAP CCCCCCCCCCCCCCC		25627689
306	Phosphorylation	PVPRLSESANPPAQR CCCCCCCCCCCCCCC		28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BOP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BOP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BOP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BRCA1_HUMAN	BRCA1	physical	25184681

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.