BGH3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BGH3_HUMAN
• UniProt AC: Q15582
• Protein Name: Transforming growth factor-beta-induced protein ig-h3
• Gene Name: TGFBI
• Organism: Homo sapiens (Human).
• Sequence Length: 683
• Subcellular Localization: Secreted . Secreted, extracellular space, extracellular matrix . May be associated both with microfibrils and with the cell surface (PubMed:8077289).
• Protein Description: Plays a role in cell adhesion. [PubMed: 8024701 May play a role in cell-collagen interactions (By similarity]
• Protein Sequence: MALFVRLLALALALALGPAATLAGPAKSPYQLVLQHSRLRGRQHGPNVCAVQKVIGTNRKYFTNCKQWYQRKICGKSTVISYECCPGYEKVPGEKGCPAALPLSNLYETLGVVGSTTTQLYTDRTEKLRPEMEGPGSFTIFAPSNEAWASLPAEVLDSLVSNVNIELLNALRYHMVGRRVLTDELKHGMTLTSMYQNSNIQIHHYPNGIVTVNCARLLKADHHATNGVVHLIDKVISTITNNIQQIIEIEDTFETLRAAVAASGLNTMLEGNGQYTLLAPTNEAFEKIPSETLNRILGDPEALRDLLNNHILKSAMCAEAIVAGLSVETLEGTTLEVGCSGDMLTINGKAIISNKDILATNGVIHYIDELLIPDSAKTLFELAAESDVSTAIDLFRQAGLGNHLSGSERLTLLAPLNSVFKDGTPPIDAHTRNLLRNHIIKDQLASKYLYHGQTLETLGGKKLRVFVYRNSLCIENSCIAAHDKRGRYGTLFTMDRVLTPPMGTVMDVLKGDNRFSMLVAAIQSAGLTETLNREGVYTVFAPTNEAFRALPPRERSRLLGDAKELANILKYHIGDEILVSGGIGALVRLKSLQGDKLEVSLKNNVVSVNKEPVAEPDIMATNGVVHVITNVLQPPANRPQERGDELADSALEIFKQASAFSRASQRSVRLAPVYQKLLERMKH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	TLAGPAKSPYQLVLQ HHCCCCCCHHHHHHH	30.83	-
28	O-linked_Glycosylation	TLAGPAKSPYQLVLQ HHCCCCCCHHHHHHH	30.83	30812951
30	Phosphorylation	AGPAKSPYQLVLQHS CCCCCCHHHHHHHHH	22.90	-
37	Phosphorylation	YQLVLQHSRLRGRQH HHHHHHHHHHCCCCC	21.76	28857561
65	S-cysteinylation	NRKYFTNCKQWYQRK CCHHHCCHHHHHHHH	2.92	27609313
457	Phosphorylation	YHGQTLETLGGKKLR HCCEEEEECCCEEEE	33.54	-
484	2-Hydroxyisobutyrylation	SCIAAHDKRGRYGTL CEEECCCCCCCCCCE	47.05	-
537	Phosphorylation	TLNREGVYTVFAPTN HHCCCCCEEEEEECC	14.19	-
590	Ubiquitination	IGALVRLKSLQGDKL HHHHEEHHHCCCCEE	38.26	-
591	Phosphorylation	GALVRLKSLQGDKLE HHHEEHHHCCCCEEE	30.43	24275569
649	Phosphorylation	RGDELADSALEIFKQ HCCHHHHHHHHHHHH	29.19	26657352
664	Phosphorylation	ASAFSRASQRSVRLA HHHHHHHHHHHHHHH	25.64	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BGH3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BGH3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BGH3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FAM9B_HUMAN	FAM9B	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.