BCAS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BCAS1_HUMAN
• UniProt AC: O75363
• Protein Name: Breast carcinoma-amplified sequence 1
• Gene Name: BCAS1
• Organism: Homo sapiens (Human).
• Sequence Length: 584
• Subcellular Localization: Cytoplasm .
• Protein Sequence: MGNQMSVPQRVEDQENEPEAETYQDNASALNGVPVVVSTHTVQHLEEVDLGISVKTDNVATSSPETTEISAVADANGKNLGKEAKPEAPAAKSRFFLMLSRPVPGRTGDQAADSSLGSVKLDVSSNKAPANKDPSESWTLPVAAGPGQDTDKTPGHAPAQDKVLSAARDPTLLPPETGGAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIVDGKEKEGQELGTADCSVPGDPEGLETAKDDSQAAAIAENNNSIMSFFKTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVDLNEGDAAPEPTEAKLKREESKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSCQTSDSTEKTITPPEPEPTGAPQKGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATVDTNSLQNGDKLQKRPEKRQQSLGGFFKGLGPKRMLDAQVQTDPVSIGPVGKSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	Phosphorylation	KTDNVATSSPETTEI ECCCCCCCCCCCCCC	33.87	26657352
63	Phosphorylation	TDNVATSSPETTEIS CCCCCCCCCCCCCCE	23.54	26657352
66	Phosphorylation	VATSSPETTEISAVA CCCCCCCCCCCEEEE	32.87	27251275
67	Phosphorylation	ATSSPETTEISAVAD CCCCCCCCCCEEEEC	29.65	26657352
85	Acetylation	KNLGKEAKPEAPAAK CCCCCCCCCCCCHHH	44.47	7408141
100	Phosphorylation	SRFFLMLSRPVPGRT CCEEEEECCCCCCCC	22.15	19562805
107	Phosphorylation	SRPVPGRTGDQAADS CCCCCCCCCCCHHHC	51.53	-
114	Phosphorylation	TGDQAADSSLGSVKL CCCCHHHCCCCCEEE	23.80	26657352
115	Phosphorylation	GDQAADSSLGSVKLD CCCHHHCCCCCEEEE	36.98	28102081
118	Phosphorylation	AADSSLGSVKLDVSS HHHCCCCCEEEECCC	22.75	28102081
124	Phosphorylation	GSVKLDVSSNKAPAN CCEEEECCCCCCCCC	28.06	-
191	Phosphorylation	APSKPKDSSFFDKFF CCCCCCCCCHHHHHC	34.86	26657352
192	Phosphorylation	PSKPKDSSFFDKFFK CCCCCCCCHHHHHCC	39.81	21815630
231	Phosphorylation	VDEVPGLSGQSDDVP HCCCCCCCCCCCCCC	40.47	26657352
256	Phosphorylation	KEGQELGTADCSVPG CCCCCCCCCCCCCCC	31.76	24114839
260	Phosphorylation	ELGTADCSVPGDPEG CCCCCCCCCCCCHHH	31.71	26657352
270	Phosphorylation	GDPEGLETAKDDSQA CCHHHHHCCCCHHHH	44.01	24114839
293	Phosphorylation	SIMSFFKTLVSPNKA HHHHHHHHHHCCCHH	27.51	27251275
296	Phosphorylation	SFFKTLVSPNKAETK HHHHHHHCCCHHHCC	26.35	25849741
302	Phosphorylation	VSPNKAETKKDPEDT HCCCHHHCCCCHHHC	48.53	23312004
309	Phosphorylation	TKKDPEDTGAEKSPT CCCCHHHCCCCCCCC	36.31	23312004
314	Phosphorylation	EDTGAEKSPTTSADL HHCCCCCCCCCCHHH	20.98	25849741
316	Phosphorylation	TGAEKSPTTSADLKS CCCCCCCCCCHHHHH	40.24	23312004
317	Phosphorylation	GAEKSPTTSADLKSD CCCCCCCCCHHHHHC	25.87	28102081
318	Phosphorylation	AEKSPTTSADLKSDK CCCCCCCCHHHHHCC	23.43	28102081
323	Phosphorylation	TTSADLKSDKANFTS CCCHHHHHCCCCCCC	52.20	26657352
346	Phosphorylation	NSKGCNPSGHTQSVT CCCCCCCCCCCCCCC	29.25	26330541
349	Phosphorylation	GCNPSGHTQSVTTPE CCCCCCCCCCCCCCC	26.51	26330541
351	Phosphorylation	NPSGHTQSVTTPEPA CCCCCCCCCCCCCCC	23.68	26657352
353	Phosphorylation	SGHTQSVTTPEPAKE CCCCCCCCCCCCCCC	41.71	26657352
354	Phosphorylation	GHTQSVTTPEPAKEG CCCCCCCCCCCCCCC	24.41	25849741
366	Phosphorylation	KEGTKEKSGPTSLPL CCCCCCCCCCCCCCC	51.61	23312004
369	Phosphorylation	TKEKSGPTSLPLGKL CCCCCCCCCCCCHHC	46.55	26657352
370	Phosphorylation	KEKSGPTSLPLGKLF CCCCCCCCCCCHHCE	30.99	25332170
381	Phosphorylation	GKLFWKKSVKEDSVP HHCEECCCCCCCCCC	34.39	26657352
386	Phosphorylation	KKSVKEDSVPTGAEE CCCCCCCCCCCCCCC	30.96	26657352
389	Phosphorylation	VKEDSVPTGAEENVV CCCCCCCCCCCCCEE	47.04	26330541
399	Phosphorylation	EENVVCESPVEIIKS CCCEEECCCCEEECC	29.17	27362937
441	Phosphorylation	REESKPRTSLMAFLR HHHCCCHHHHHHHHH	34.44	26657352
442	Phosphorylation	EESKPRTSLMAFLRQ HHCCCHHHHHHHHHH	19.89	26657352
451	Phosphorylation	MAFLRQMSVKGDGGI HHHHHHHCCCCCCCC	16.61	26657352
459	Phosphorylation	VKGDGGITHSEEING CCCCCCCCCCHHHCC	23.71	26330541
461	Phosphorylation	GDGGITHSEEINGKD CCCCCCCCHHHCCCC	28.42	26330541
480	Phosphorylation	TSDSTEKTITPPEPE CCCCCCCCCCCCCCC	24.69	25332170
482	Phosphorylation	DSTEKTITPPEPEPT CCCCCCCCCCCCCCC	37.71	18510355
482 (in isoform 2)	Phosphorylation	-	37.71	29978859
483 (in isoform 2)	Phosphorylation	-	27.66	29978859
485 (in isoform 2)	Phosphorylation	-	64.60	29978859
486 (in isoform 2)	Phosphorylation	-	59.65	29978859
489	Phosphorylation	TPPEPEPTGAPQKGK CCCCCCCCCCCCCCC	44.29	23312004
489 (in isoform 2)	Phosphorylation	-	44.29	29978859
491 (in isoform 2)	Phosphorylation	-	13.06	29978859
498 (in isoform 2)	Phosphorylation	-	40.48	29978859
505	Phosphorylation	GSSKDKKSAAEMNKQ CCHHHHHHHHHHHHH	38.15	26657352
535	Phosphorylation	QATVDTNSLQNGDKL CEEECCCCCCCCHHH	33.16	25849741
552	Phosphorylation	RPEKRQQSLGGFFKG CHHHHHHHHHHHHCC	22.20	26657352

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BCAS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BCAS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BCAS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DYL1_HUMAN	DYNLL1	physical	17353931
RUVB2_HUMAN	RUVBL2	physical	17353931
BCAS1_HUMAN	BCAS1	physical	14567997

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.