dbPTM

BARD1_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BARD1_CAEEL
UniProt AC	Q21209
Protein Name	BRCA1-associated RING domain protein 1 {ECO:0000303\|PubMed:16628214}
Gene Name	brd-1 {ECO:0000303\|PubMed:14711411, ECO:0000312\|WormBase:K04C2.4}
Organism	Caenorhabditis elegans.
Sequence Length	702
Subcellular Localization	Cytoplasm . Nucleus . Chromosome .
Protein Description	Involved in ubiquitination. Constituent of the CeBCD complex that possesses E3 ubiquitin-protein ligase activity. Involved in DNA repair. Has a reactive role in the response to DNA damage by ionizing radiation. Protects against chromosome non-disjunction and fragmentation to aid chromosome stability..
Protein Sequence	MFENTKKALETFRTAIECVKCKKPRGDLQYLGSSCKHAYCWECIATFQQKPSGKRSSVARHMCPSCAFPLDTSKITEAHMLKTCFDTLSELNDLLQKVGTTSLTQAEFACTQNIFNKEKTPADAVEKFLETQAHMPDEMGQLGEEDDDLMCKDENRENSNSPELDIFHDYSKEASPTRNSTKRPSTVSVHERKPKRSSILKTSVKNEPAAPVVDLFASQVPQRTHQNDLLTPFIERRSTAPAATGVATYAQAFGSSSNPVKAEIIEEDIFSKAIPLTKRQASMSASAKKQPKLEPEEPEEVPSTSRSRKNSIKSDKIERRSQSPMSFGEKSMSVKSEQRRSSYGTRRGEAVLVNSIRNNRIPQLRSAVEAGTCVNEKEDGKTPLYVAVENSSLEAVKILVEAGAVINASCGSTLETTLHEAVRRQNTQIVEYLLSKGASIKIRNIAGKTVEEMAKSDPKIRKIIEKFKTEQRVLQPVVAPPKSRLHFVQLIDEKMLTESEKRKLPGKINIVPADMDSPTHVVVTVDLKTRVLNINKEHIGEILKAIIKSGMIVSRDWLRACIIDPSKVDDDRSYMVQKVRWMEGEVFENTIEQWKKTITKMQPKLFAGCKFFIPKPKYNFLDRPALFEIIRSAGGQAAAREPIIDEKDPPPYHNANLKPNFVLYSLTHDIGDKFRDCTKYNLVSEQWLIEAILGCSITTPPH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
175	Phosphorylation	HDYSKEASPTRNSTK CCCCCCCCCCCCCCC	28.09	30078680
303	Phosphorylation	EEPEEVPSTSRSRKN CCCCCCCCCCHHHCC	44.16	30078680
304	Phosphorylation	EPEEVPSTSRSRKNS CCCCCCCCCHHHCCC	23.30	30078680
305	Phosphorylation	PEEVPSTSRSRKNSI CCCCCCCCHHHCCCC	32.37	30078680

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of BARD1_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BARD1_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BARD1_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SUMO_CAEEL	smo-1	physical	14704431

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BARD1_CAEEL

Related Literatures of Post-Translational Modification