BAG7_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BAG7_ARATH
• UniProt AC: Q9LVA0
• Protein Name: BAG family molecular chaperone regulator 7
• Gene Name: BAG7
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 446
• Subcellular Localization: Endoplasmic reticulum .
• Protein Description: Co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses. Necessary for the proper maintenance of the unfolded protein response (UPR) during heat and cold tolerance..
• Protein Sequence: MTLFHRLDLIDPYTCTPLIVRETSIVEPSSLFLGFPSFIDEDIEDLFEFSSPNPLDLFETVTDLVKIKKSPSSCKYKVIRRRLEPEYPLKYLCDRVSDLESKFDRLVSPKSDRKYTLTKEIKGSGERKYKWEAEIQGPLERKYKLEAEIEGSGERKYRWTTEIKGGKKDEEGLKLAALKKEKAKAKAIAAAEAEKKKNKNKKKSYNWTTEVKSERENGEVSHTYIIKATTGGEKKKKHEEKEKKEKIETKSKKKEKTRVVVIEEEEEEDDESSEHGAIVLRKAFSRRNGAVRTKKGKNKEMPPEYAAVMIQRAFKAYLIRRSKSLRALRDLAIAKTKLKELRASFHNFSYRRLIARDGEERQKFSEKIIVLLLTVDAIEGVDVMVRGAKRSMVDELEAMLDVVDPQPQGKSLSMRRRTFDMPDSLIRKEIAEGVTQIVQMLETEEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	LDLIDPYTCTPLIVR CCCCCCCCCCCEEEE	18.45	23328941
97	Phosphorylation	KYLCDRVSDLESKFD HHHHHHHHHHHHHHH	37.05	30291188
101	Phosphorylation	DRVSDLESKFDRLVS HHHHHHHHHHHHHCC	46.01	30291188
108	Phosphorylation	SKFDRLVSPKSDRKY HHHHHHCCCCCCCCE	31.07	26658240
115	Phosphorylation	SPKSDRKYTLTKEIK CCCCCCCEEECEECC	14.10	19880383
116	Phosphorylation	PKSDRKYTLTKEIKG CCCCCCEEECEECCC	30.87	23820729
118	Phosphorylation	SDRKYTLTKEIKGSG CCCCEEECEECCCCC	20.87	23820729
124	Phosphorylation	LTKEIKGSGERKYKW ECEECCCCCCCCEEE	32.26	25561503
152	Phosphorylation	LEAEIEGSGERKYRW EEEEEECCCCCEEEE	25.37	17317660
272	Phosphorylation	EEEEDDESSEHGAIV CCCCCCCCCCCHHHH	48.28	23111157
273	Phosphorylation	EEEDDESSEHGAIVL CCCCCCCCCCHHHHH	31.40	23111157
392	Sulfoxidation	VRGAKRSMVDELEAM HCCCCHHHHHHHHHH	5.24	23289948
399	Sulfoxidation	MVDELEAMLDVVDPQ HHHHHHHHHHHCCCC	2.10	23289948
424	Phosphorylation	RTFDMPDSLIRKEIA HCCCCCHHHHHHHHH	21.59	30407730
435	Phosphorylation	KEIAEGVTQIVQMLE HHHHHHHHHHHHHHH	24.35	23776212
440	Sulfoxidation	GVTQIVQMLETEEE- HHHHHHHHHHHCCC-	2.24	23289948
443	Phosphorylation	QIVQMLETEEE---- HHHHHHHHCCC----	44.74	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BAG7_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BAG7_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BAG7_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MD37F_ARATH	BIP2	physical	20231441

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-443, AND MASSSPECTROMETRY.
PubMed: 19376835