AXR1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AXR1_ARATH
• UniProt AC: P42744
• Protein Name: NEDD8-activating enzyme E1 regulatory subunit AXR1 {ECO:0000305}
• Gene Name: AXR1 {ECO:0000303|PubMed:8321287}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 540
• Subcellular Localization: Nucleus .
• Protein Description: Regulatory subunit of the dimeric ECR1-AXR1 E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1. Plays an important role in auxin response. [PubMed: 8321287 Regulates the chromosomal localization of meiotic recombination by crossovers (COs) and subsequent synapsis, probably through the activation of a CRL4 complex]
• Protein Sequence: MQAVKRSRRHVEEEPTMVEPKTKYDRQLRIWGEVGQAALEEASICLLNCGPTGSEALKNLVLGGVGSITVVDGSKVQFGDLGNNFMVDAKSVGQSKAKSVCAFLQELNDSVNAKFIEENPDTLITTNPSFFSQFTLVIATQLVEDSMLKLDRICRDANVKLVLVRSYGLAGFVRISVKEHPIIDSKPDHFLDDLRLNNPWPELKSFVETIDLNVSEPAAAHKHIPYVVILVKMAEEWAQSHSGNLPSTREEKKEFKDLVKSKMVSTDEDNYKEAIEAAFKVFAPRGISSEVQKLINDSCAEVNSNSSAFWVMVAALKEFVLNEGGGEAPLEGSIPDMTSSTEHYINLQKIYLAKAEADFLVIEERVKNILKKIGRDPSSIPKPTIKSFCKNARKLKLCRYRMVEDEFRNPSVTEIQKYLADEDYSGAMGFYILLRAADRFAANYNKFPGQFDGGMDEDISRLKTTALSLLTDLGCNGSVLPDDLIHEMCRFGASEIHVVSAFVGGIASQEVIKLVTKQFVPMLGTYIFNGIDHKSQLLKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	Phosphorylation	LVLGGVGSITVVDGS HHCCCCCEEEEECCC		28011693
69	Phosphorylation	LGGVGSITVVDGSKV CCCCCEEEEECCCEE		28011693
378	Phosphorylation	KKIGRDPSSIPKPTI HHHCCCHHHCCCHHH		25561503
379	Phosphorylation	KIGRDPSSIPKPTIK HHCCCHHHCCCHHHH		25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AXR1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AXR1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AXR1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RCE1_ARATH	RCE1	physical	12682009
RUB1_ARATH	RUB1	physical	25783028

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.