AVP1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AVP1_ARATH
• UniProt AC: P31414
• Protein Name: Pyrophosphate-energized vacuolar membrane proton pump 1
• Gene Name: AVP1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 770
• Subcellular Localization: Vacuole membrane ; Multi-pass membrane protein . Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Mostly vacuolar, tonoplast. Also present in endosomes and plasma membrane.
• Protein Description: Contributes to the transtonoplast (from cytosol to vacuole lumen) H(+)-electrochemical potential difference. It establishes a proton gradient of similar and often greater magnitude than the H(+)-ATPase on the same membrane. In addition, facilitates auxin transport by modulating apoplastic pH and regulates auxin-mediated developmental processes. Confers tolerance to NaCl and to drought by increasing ion retention..
• Protein Sequence: MVAPALLPELWTEILVPICAVIGIAFSLFQWYVVSRVKLTSDLGASSSGGANNGKNGYGDYLIEEEEGVNDQSVVAKCAEIQTAISEGATSFLFTEYKYVGVFMIFFAAVIFVFLGSVEGFSTDNKPCTYDTTRTCKPALATAAFSTIAFVLGAVTSVLSGFLGMKIATYANARTTLEARKGVGKAFIVAFRSGAVMGFLLAASGLLVLYITINVFKIYYGDDWEGLFEAITGYGLGGSSMALFGRVGGGIYTKAADVGADLVGKIERNIPEDDPRNPAVIADNVGDNVGDIAGMGSDLFGSYAEASCAALVVASISSFGINHDFTAMCYPLLISSMGILVCLITTLFATDFFEIKLVKEIEPALKNQLIISTVIMTVGIAIVSWVGLPTSFTIFNFGTQKVVKNWQLFLCVCVGLWAGLIIGFVTEYYTSNAYSPVQDVADSCRTGAATNVIFGLALGYKSVIIPIFAIAISIFVSFSFAAMYGVAVAALGMLSTIATGLAIDAYGPISDNAGGIAEMAGMSHRIRERTDALDAAGNTTAAIGKGFAIGSAALVSLALFGAFVSRAGIHTVDVLTPKVIIGLLVGAMLPYWFSAMTMKSVGSAALKMVEEVRRQFNTIPGLMEGTAKPDYATCVKISTDASIKEMIPPGCLVMLTPLIVGFFFGVETLSGVLAGSLVSGVQIAISASNTGGAWDNAKKYIEAGVSEHAKSLGPKGSEPHKAAVIGDTIGDPLKDTSGPSLNILIKLMAVESLVFAPFFATHGGILFKYF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	VSRVKLTSDLGASSS HHCCEECCCCCCCCC	41.07	25561503
46	Phosphorylation	LTSDLGASSSGGANN ECCCCCCCCCCCCCC	24.20	19880383
47	Phosphorylation	TSDLGASSSGGANNG CCCCCCCCCCCCCCC	32.25	19880383
48	Phosphorylation	SDLGASSSGGANNGK CCCCCCCCCCCCCCC	38.46	19880383
618	Phosphorylation	EVRRQFNTIPGLMEG HHHHHHCCCCCCCCC	29.82	19880383
633	Phosphorylation	TAKPDYATCVKISTD CCCCCCEEEEEECCC	16.17	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AVP1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AVP1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AVP1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HHP2_ARATH	HHP2	physical	24833385
UBC34_ARATH	UBC34	physical	24833385
CP21D_ARATH	AT3G66654	physical	24833385

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.