dbPTM

ATXR6_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ATXR6_ARATH
UniProt AC	Q9FNE9
Protein Name	Histone-lysine N-methyltransferase ATXR6
Gene Name	ATXR6
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	349
Subcellular Localization	Nucleus .
Protein Description	Histone methyltransferase that specifically monomethylates 'Lys-37' of histone H3 (H3K27me1). Has higher activity on nucleosomes containing H3.1 than H3.3. Involved in the formation of constitutive heterochromatin and the silencing of heterochromatic elements. May act as a positive regulator of the G1-S transition. Influences which sets of rRNA gene variants are expressed or silenced. Up-regulated by E2FB..
Protein Sequence	MVAVRRRRTQASNPRSEPPQHMSDHDSDSDWDTVCEECSSGKQPAKLLLCDKCDKGFHLFCLRPILVSVPKGSWFCPSCSKHQIPKSFPLIQTKIIDFFRIKRSPDSSQISSSSDSIGKKRKKTSLVMSKKKRRLLPYNPSNDPQRRLEQMASLATALRASNTKFSNELTYVSGKAPRSANQAAFEKGGMQVLSKEGVETLALCKKMMDLGECPPLMVVFDPYEGFTVEADRFIKDWTIITEYVGDVDYLSNREDDYDGDSMMTLLHASDPSQCLVICPDRRSNIARFISGINNHSPEGRKKQNLKCVRFNINGEARVLLVANRDISKGERLYYDYNGYEHEYPTEHFV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
104	Phosphorylation	DFFRIKRSPDSSQIS EEEEECCCCCHHHCC	28.23	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ATXR6_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ATXR6_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ATXR6_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCNA1_ARATH	PCNA1	physical	19812700
H33_ARATH	AT4G40030	physical	19503079
INO1_ARATH	MIPS1	physical	23341037

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ATXR6_ARATH

Related Literatures of Post-Translational Modification