dbPTM

ATOH8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ATOH8_HUMAN
UniProt AC	Q96SQ7
Protein Name	Protein atonal homolog 8
Gene Name	ATOH8 {ECO:0000312\|HGNC:HGNC:24126}
Organism	Homo sapiens (Human).
Sequence Length	321
Subcellular Localization	Nucleus . Nucleus speckle . Cytoplasm .
Protein Description	Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins. [PubMed: 24236640 Regulates endothelial cell proliferation, migration and tube-like structures formation]
Protein Sequence	MKHIPVLEDGPWKTVCVKELNGLKKLKRKGKEPARRANGYKTFRLDLEAPEPRAVATNGLRDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPTPPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPESTVRPAPPTRPGESSYSSISHVIYNNHQDSSASPRKRPGEATAASSEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARLADLDYSADHSNLSFSECVQRCTRTLQAEGRAKKRKE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Acetylation	VKELNGLKKLKRKGK HHHHHHHHHHHHCCC	58.41	130775
25	Acetylation	KELNGLKKLKRKGKE HHHHHHHHHHHCCCC	65.37	90491
27	Acetylation	LNGLKKLKRKGKEPA HHHHHHHHHCCCCCH	62.03	7339573
29	Acetylation	GLKKLKRKGKEPARR HHHHHHHCCCCCHHH	73.14	90493
218	Phosphorylation	RKRPGEATAASSEIK CCCCCCCCHHHHHHH	20.60	28450419
221	Phosphorylation	PGEATAASSEIKALQ CCCCCHHHHHHHHHH	26.49	28450419
222	Phosphorylation	GEATAASSEIKALQQ CCCCHHHHHHHHHHH	38.32	28450419
245	Phosphorylation	RERTRVHTISAAFEA HHHHHHHHHHHHHHH	17.48	-
247	Phosphorylation	RTRVHTISAAFEALR HHHHHHHHHHHHHHH	18.07	22496350

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ATOH8_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ATOH8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ATOH8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CP3A5_HUMAN	CYP3A5	physical	21988832

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ATOH8_HUMAN

Related Literatures of Post-Translational Modification