ATG2A_MOUSE - dbPTM
ATG2A_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATG2A_MOUSE
UniProt AC Q6P4T0
Protein Name Autophagy-related protein 2 homolog A
Gene Name Atg2a
Organism Mus musculus (Mouse).
Sequence Length 1914
Subcellular Localization Preautophagosomal structure membrane
Peripheral membrane protein. Lipid droplet.
Protein Description Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (By similarity). Mediates the intracellular lifestyle of Cryptococcus neoformans by supporting infection..
Protein Sequence MSRWLWPWSNCVKERVCRYLLQHYLGHFFQEHLSLDQLSLDLYKGSVALRDIHLETWSVNEFLRSMESPLELVEGFVSSIEVAVPWAALLTDHCTVCVSGLQLTLQPRQGSGPGAADSQSWASCMTTSLQLAQECLREGLPEPSEPPQPLEGLEMFAQTIETVLRRIKVTFLNTVVRVEHSLGDEDRSVAVEVRVQRLEYCDEAVRDPSQAPPVDVHQPPAFLHKLLQLSGVCLYFEELPSQADPPQPPLQIGSCTGYVELMVRLKQNEAFPGPKLEVSGQLGSLHLLLTPRQLQQLQRLLSAVNLADPAGLADKLNKSRPLGAEDLWLIEQDLNQQLQAGAVAESLSLYPITNPLNLDSTDLFFSMAGLTSSVTSAVSELSVYSVDLGSSVHSNMAFHRPSTPPHSGGKMAPTPLLDTTRPDSLVKMTLGGVSLTLLQTASPSSGPSDLPTHFFAEFDAAKDGPFGSRDFSHLRPRFQRACPCSHVRLTGTAVQLSWELRTGSHSRRTSSTEVHFGQLEVLECLWPRAATEPEYTEILSFPSHSGSEASARPCAHLRHTQTIRRVLKSRSRRSTACHCHSELSLDLADFQSDVELGSLDRLAALFRQVTTPSEPPAGLLTEPPQATELQTVFRLSAPRATLRLRFPIPDLRPDRDPWAGQAVRAEQLRLELSEPQFRSELNSGPGPPAPTRLELTCSDLQGIYEDGEKPPVPCLRVSKALNPRSTEAKYFLPQVVVTLNPQSSGTQWETAYEKGRDLELSTESPCELQQPEPSPFSSKRTMYETEEMVIPGDPEEMRTFQSRTLALSRCTLDVIMPSAHIFLPSKEVYESIYNRINNDLLMWEPADLLPTSSAAARPPGSSGFKMCKSAFKLDSDSDEEDAQFFSMASGVPQTPAPEPSRRQSQSTFSTLVTVLKGRITALCEAKDETGKRLDVTHGELVLDVEQGTIFSVAQYRGQPGLGYFCLEAEKAKLYHRAAIEDYLLPTHLEVPSFAPPAQLAPTIYPSEEGVTERGTLGRKGQGPPMLSAAVRIHLDPHKNVKEFLVTVRLHKATLRHYMAPPEQSWHSQLLDFLDVLDDPVLGYLPPTVITVLHTHLFSCAVDYRPLYLPVRVLVTAETFTLSSNIVMDTSTFLLRFILDDSALYLSDKCEVESLDLRRDYVCVLDIDLLELVIKTWKGSTEGRLSQPLFELRCSNNVVHVHSCADSCALLVNLLQYLTSSGDLHPPPRPPSPTEIAGQKLSESPASLPSCLPVETALINQRDLTDALLDTERRGLQELAQSSGGPLPQASPVSVYLFPGERSGAQAPLPPPGASSHTLGSKAKEHENEEEGDGDTLDSDEFCILDAPGLGIAPRDGEPIVTQLHPGPIIVHDGHFSQPLGSTDLLRAPAHFPVPSSRVVLREVSFIWHLYGGRDFGLHPTYRARVGLTGPRVSPSRSSGPNRPQNSWRTQGGIGRQHQVLMEIQLSKVSFQHEVYPEESAIAGGLGQELDERPLSRQVLIVQELEIRDRLATSKINKFLHLHTSERLPRRTHSNMLTIKALHVAPTSSVGGPECCLRVSMMPLRLNVDQDALFFLKDFFTSLAASINPMVPGDTSEAPRETHSRPGSPQEGQSEDTETASNPPEAPGSSHSSSDQQPIYFREFRFTSEVPICLDYHGKHVTVDQVGTFMGLLIGLAQLNCSELKLKRLCCRHGLLGVDKVLCYALNEWLQDIRKNQLPGLLGGVGPMHSVVQLFQGFRDLLWLPIEQYRKDGRLIRGLQRGAASFGSSTASAALELSNRLVQAIQATAETVYDILSPASPVSRSLQDKRSSRKLRRGQQPADLREGMAKAYDAVREGILDTAQTICDVASRGHEQKGLTGAVGGVIRQLPPTVVKPIIVATEATSNVLGGMRNQILPDAHKDHALKWRLEEAQD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
315UbiquitinationDPAGLADKLNKSRPL
CHHHHHHHHCCCCCC		48.6422790023
592PhosphorylationLDLADFQSDVELGSL
CCHHHHCCCCCCCCH		43.55-
598PhosphorylationQSDVELGSLDRLAAL
CCCCCCCCHHHHHHH		39.46-
636PhosphorylationLQTVFRLSAPRATLR
CEEEEECCCCCCEEE		31.7824719451
679PhosphorylationLSEPQFRSELNSGPG
HCCHHHHHHHHCCCC		47.9629899451
761PhosphorylationKGRDLELSTESPCEL
CCCCCCCCCCCCCCC		22.2826643407
762PhosphorylationGRDLELSTESPCELQ
CCCCCCCCCCCCCCC		53.7826643407
764PhosphorylationDLELSTESPCELQQP
CCCCCCCCCCCCCCC		34.6326643407
774PhosphorylationELQQPEPSPFSSKRT
CCCCCCCCCCCCCCC		36.5929514104
869PhosphorylationSGFKMCKSAFKLDSD
CHHHHCHHHCCCCCC		33.7321659605
875PhosphorylationKSAFKLDSDSDEEDA
HHHCCCCCCCCHHHH		49.8321082442
877PhosphorylationAFKLDSDSDEEDAQF
HCCCCCCCCHHHHHH		51.3721082442
889PhosphorylationAQFFSMASGVPQTPA
HHHHHHHCCCCCCCC		31.5129899451
900PhosphorylationQTPAPEPSRRQSQST
CCCCCCCCCCCCHHH		38.1329899451
904PhosphorylationPEPSRRQSQSTFSTL
CCCCCCCCHHHHHHH		25.0425521595
906PhosphorylationPSRRQSQSTFSTLVT
CCCCCCHHHHHHHHH		36.3423984901
907PhosphorylationSRRQSQSTFSTLVTV
CCCCCHHHHHHHHHH		17.6123984901
909PhosphorylationRQSQSTFSTLVTVLK
CCCHHHHHHHHHHHH		22.4123984901
910PhosphorylationQSQSTFSTLVTVLKG
CCHHHHHHHHHHHHH		22.5123984901
970UbiquitinationYFCLEAEKAKLYHRA
EEEEEHHHHHHHHHH		58.8522790023
1179PhosphorylationVIKTWKGSTEGRLSQ
HHHHCCCCCCCCCCC		21.4020495213
1241PhosphorylationEIAGQKLSESPASLP
CCCCCCCCCCCCCCC		42.9626824392
1243PhosphorylationAGQKLSESPASLPSC
CCCCCCCCCCCCCCC		23.5326824392
1246PhosphorylationKLSESPASLPSCLPV
CCCCCCCCCCCCCCC		44.1722942356
1249PhosphorylationESPASLPSCLPVETA
CCCCCCCCCCCCCHH		33.3121082442
1255PhosphorylationPSCLPVETALINQRD
CCCCCCCHHCCCHHH		27.3125619855
1282PhosphorylationLQELAQSSGGPLPQA
HHHHHHHCCCCCCCC		35.37-
1290PhosphorylationGGPLPQASPVSVYLF
CCCCCCCCCCEEEEE		22.1626643407
1293PhosphorylationLPQASPVSVYLFPGE
CCCCCCCEEEEECCC		14.3926643407
1295PhosphorylationQASPVSVYLFPGERS
CCCCCEEEEECCCCC		8.6326643407
1335PhosphorylationEEEGDGDTLDSDEFC
CCCCCCCCCCCCCEE		37.6821743459
1338PhosphorylationGDGDTLDSDEFCILD
CCCCCCCCCCEEEEC		42.0021743459
1381PhosphorylationHFSQPLGSTDLLRAP
CCCCCCCCCCCCCCC		26.82-
1428PhosphorylationYRARVGLTGPRVSPS
HHCCCCCCCCCCCCC		38.9329899451
1433PhosphorylationGLTGPRVSPSRSSGP
CCCCCCCCCCCCCCC		20.5922324799
1435PhosphorylationTGPRVSPSRSSGPNR
CCCCCCCCCCCCCCC		36.9722324799
1446PhosphorylationGPNRPQNSWRTQGGI
CCCCCCCCCCCCCCC		16.8225338131
1469PhosphorylationEIQLSKVSFQHEVYP
EEEECCCEECCCCCC		23.95-
1475PhosphorylationVSFQHEVYPEESAIA
CEECCCCCCHHHHCC		11.27-
1479PhosphorylationHEVYPEESAIAGGLG
CCCCCHHHHCCCCCC		24.26-
1601PhosphorylationTSEAPRETHSRPGSP
CCCCCCCCCCCCCCC		26.8217242355
1603PhosphorylationEAPRETHSRPGSPQE
CCCCCCCCCCCCCCC		47.8127087446
1607PhosphorylationETHSRPGSPQEGQSE
CCCCCCCCCCCCCCC		26.5427087446
1613PhosphorylationGSPQEGQSEDTETAS
CCCCCCCCCCCCCCC		48.5823684622
1616PhosphorylationQEGQSEDTETASNPP
CCCCCCCCCCCCCCC		31.0525293948
1618PhosphorylationGQSEDTETASNPPEA
CCCCCCCCCCCCCCC		37.1627087446
1620PhosphorylationSEDTETASNPPEAPG
CCCCCCCCCCCCCCC		58.2427087446
1628PhosphorylationNPPEAPGSSHSSSDQ
CCCCCCCCCCCCCCC		24.6625338131
1787PhosphorylationLVQAIQATAETVYDI
HHHHHHHHHHHHHHH		14.5121149613
1790PhosphorylationAIQATAETVYDILSP
HHHHHHHHHHHHHCC		23.1521149613
1792PhosphorylationQATAETVYDILSPAS
HHHHHHHHHHHCCCC		12.5121149613
1796PhosphorylationETVYDILSPASPVSR
HHHHHHHCCCCCCCH		20.8226643407
1799PhosphorylationYDILSPASPVSRSLQ
HHHHCCCCCCCHHHH		29.2621149613
1802PhosphorylationLSPASPVSRSLQDKR
HCCCCCCCHHHHCHH		21.3821149613
1810PhosphorylationRSLQDKRSSRKLRRG
HHHHCHHHHHHHHCC		39.9924719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ATG2A_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATG2A_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATG2A_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BAG2_HUMANBAG2physical
26496610
WIPI4_HUMANWDR45physical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATG2A_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-875 AND SER-877, ANDMASS SPECTROMETRY.

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