AT11B_HUMAN - dbPTM
AT11B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AT11B_HUMAN
UniProt AC Q9Y2G3
Protein Name Probable phospholipid-transporting ATPase IF
Gene Name ATP11B
Organism Homo sapiens (Human).
Sequence Length 1177
Subcellular Localization Recycling endosome membrane
Multi-pass membrane protein. Early endosome . Endoplasmic reticulum . Golgi apparatus, trans-Golgi network . Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B (PubMed:21914794). In the
Protein Description Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). Involved in regulation of sensitivity to cisplatin; may contribute to secretory vesicle transport of cisplatin from Golgi to plasma membrane..
Protein Sequence MWRWIRQQLGFDPPHQSDTRTIYVANRFPQNGLYTPQKFIDNRIISSKYTVWNFVPKNLFEQFRRVANFYFLIIFLVQLMIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHNSDNEVNGAPVYVVRSGGLVKTRSKNIRVGDIVRIAKDEIFPADLVLLSSDRLDGSCHVTTASLDGETNLKTHVAVPETALLQTVANLDTLVAVIECQQPEADLYRFMGRMIITQQMEEIVRPLGPESLLLRGARLKNTKEIFGVAVYTGMETKMALNYKSKSQKRSAVEKSMNTFLIIYLVILISEAVISTILKYTWQAEEKWDEPWYNQKTEHQRNSSKILRFISDFLAFLVLYNFIIPISLYVTVEMQKFLGSFFIGWDLDLYHEESDQKAQVNTSDLNEELGQVEYVFTDKTGTLTENEMQFRECSINGMKYQEINGRLVPEGPTPDSSEGNLSYLSSLSHLNNLSHLTTSSSFRTSPENETELIKEHDLFFKAVSLCHTVQISNVQTDCTGDGPWQSNLAPSQLEYYASSPDEKALVEAAARIGIVFIGNSEETMEVKTLGKLERYKLLHILEFDSDRRRMSVIVQAPSGEKLLFAKGAESSILPKCIGGEIEKTRIHVDEFALKGLRTLCIAYRKFTSKEYEEIDKRIFEARTALQQREEKLAAVFQFIEKDLILLGATAVEDRLQDKVRETIEALRMAGIKVWVLTGDKHETAVSVSLSCGHFHRTMNILELINQKSDSECAEQLRQLARRITEDHVIQHGLVVDGTSLSLALREHEKLFMEVCRNCSAVLCCRMAPLQKAKVIRLIKISPEKPITLAVGDGANDVSMIQEAHVGIGIMGKEGRQAARNSDYAIARFKFLSKLLFVHGHFYYIRIATLVQYFFYKNVCFITPQFLYQFYCLFSQQTLYDSVYLTLYNICFTSLPILIYSLLEQHVDPHVLQNKPTLYRDISKNRLLSIKTFLYWTILGFSHAFIFFFGSYLLIGKDTSLLGNGQMFGNWTFGTLVFTVMVITVTVKMALETHFWTWINHLVTWGSIIFYFVFSLFYGGILWPFLGSQNMYFVFIQLLSSGSAWFAIILMVVTCLFLDIIKKVFDRHLHPTSTEKAQLTETNAGIKCLDSMCCFPEGEAACASVGRMLERVIGRCSPTHISRSWSASDPFYTNDRSILTLSTMDSSTC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17PhosphorylationGFDPPHQSDTRTIYV
CCCCCCCCCCCEEEE		37.60-
19PhosphorylationDPPHQSDTRTIYVAN
CCCCCCCCCEEEEEE		34.6526074081
21PhosphorylationPHQSDTRTIYVANRF
CCCCCCCEEEEEECC		20.8226074081
23PhosphorylationQSDTRTIYVANRFPQ
CCCCCEEEEEECCCC		7.9026074081
34PhosphorylationRFPQNGLYTPQKFID
CCCCCCCCCCHHHCC		20.13-
38UbiquitinationNGLYTPQKFIDNRII
CCCCCCHHHCCCCCC		45.55-
125PhosphorylationEVNGAPVYVVRSGGL
CCCCCCEEEEECCCE		7.68-
261PhosphorylationEIFGVAVYTGMETKM
HEEEEEEECCHHHHH		6.4529116813
262PhosphorylationIFGVAVYTGMETKMA
EEEEEEECCHHHHHH		24.3729116813
266PhosphorylationAVYTGMETKMALNYK
EEECCHHHHHHHCCC		19.7529116813
272PhosphorylationETKMALNYKSKSQKR
HHHHHHCCCCHHHHH		19.9329116813
274PhosphorylationKMALNYKSKSQKRSA
HHHHCCCCHHHHHHH		27.4629116813
276PhosphorylationALNYKSKSQKRSAVE
HHCCCCHHHHHHHHH		48.2829116813
326O-linked_GlycosylationEPWYNQKTEHQRNSS
CCCCCCCCHHHHCHH		29.0030620550
403PhosphorylationEELGQVEYVFTDKTG
HHHCCEEEEEECCCC		11.2927642862
428UbiquitinationECSINGMKYQEINGR
ECCCCCEEEEEECCE		45.22-
442PhosphorylationRLVPEGPTPDSSEGN
EECCCCCCCCCCCCC		51.0527135362
445PhosphorylationPEGPTPDSSEGNLSY
CCCCCCCCCCCCHHH		31.3426657352
446PhosphorylationEGPTPDSSEGNLSYL
CCCCCCCCCCCHHHH		57.8326657352
451PhosphorylationDSSEGNLSYLSSLSH
CCCCCCHHHHHHCHH		28.2028796482
452PhosphorylationSSEGNLSYLSSLSHL
CCCCCHHHHHHCHHH		17.4828796482
454PhosphorylationEGNLSYLSSLSHLNN
CCCHHHHHHCHHHCC		22.4728796482
455PhosphorylationGNLSYLSSLSHLNNL
CCHHHHHHCHHHCCC		31.1528796482
457PhosphorylationLSYLSSLSHLNNLSH
HHHHHHCHHHCCCHH		28.0728348404
463PhosphorylationLSHLNNLSHLTTSSS
CHHHCCCHHCCCCCC		20.6928348404
466PhosphorylationLNNLSHLTTSSSFRT
HCCCHHCCCCCCCCC		21.1428348404
467PhosphorylationNNLSHLTTSSSFRTS
CCCHHCCCCCCCCCC		32.7328348404
468PhosphorylationNLSHLTTSSSFRTSP
CCHHCCCCCCCCCCC		20.8128348404
469PhosphorylationLSHLTTSSSFRTSPE
CHHCCCCCCCCCCCC		31.2528348404
470PhosphorylationSHLTTSSSFRTSPEN
HHCCCCCCCCCCCCC		20.6528348404
473PhosphorylationTTSSSFRTSPENETE
CCCCCCCCCCCCHHH		46.7730108239
474PhosphorylationTSSSFRTSPENETEL
CCCCCCCCCCCHHHH		26.4321815630
479PhosphorylationRTSPENETELIKEHD
CCCCCCHHHHHHHCH		47.9030108239
483UbiquitinationENETELIKEHDLFFK
CCHHHHHHHCHHHHH		62.71-
599PhosphorylationLFAKGAESSILPKCI
EEECCCCCCCCCHHH		23.3423403867
600PhosphorylationFAKGAESSILPKCIG
EECCCCCCCCCHHHC		21.4623403867
612UbiquitinationCIGGEIEKTRIHVDE
HHCCCEEECEEEHHH		49.08-
623UbiquitinationHVDEFALKGLRTLCI
EHHHHHHHHHHHHHH		53.09-
638UbiquitinationAYRKFTSKEYEEIDK
HHHHCCCHHHHHHHH		62.35-
706PhosphorylationGIKVWVLTGDKHETA
CCEEEEEECCCCCEE		33.44-
726PhosphorylationSCGHFHRTMNILELI
ECCCHHHHHHHHHHH		13.14-
736UbiquitinationILELINQKSDSECAE
HHHHHHCCCHHHHHH		52.31-
788PhosphorylationMEVCRNCSAVLCCRM
HHHHHCCCCHHHCCC		25.5929449344
802UbiquitinationMAPLQKAKVIRLIKI
CCHHCCCEEEEEEEE		45.27-
957PhosphorylationISKNRLLSIKTFLYW
CCCCCHHHHHHHHHH		26.9924719451
1145PhosphorylationERVIGRCSPTHISRS
HHHHCCCCCCCCCCC		31.3226657352
1147PhosphorylationVIGRCSPTHISRSWS
HHCCCCCCCCCCCCC		18.6228122231
1150PhosphorylationRCSPTHISRSWSASD
CCCCCCCCCCCCCCC		16.8025404012
1152PhosphorylationSPTHISRSWSASDPF
CCCCCCCCCCCCCCC		20.7021945579
1154PhosphorylationTHISRSWSASDPFYT
CCCCCCCCCCCCCCC		21.0923927012
1156PhosphorylationISRSWSASDPFYTND
CCCCCCCCCCCCCCC		40.0621945579
1160PhosphorylationWSASDPFYTNDRSIL
CCCCCCCCCCCCCEE		15.2621945579
1161PhosphorylationSASDPFYTNDRSILT
CCCCCCCCCCCCEEE		30.9021945579
1170PhosphorylationDRSILTLSTMDSSTC
CCCEEEEEECCCCCC		19.2227690223
1171PhosphorylationRSILTLSTMDSSTC-
CCEEEEEECCCCCC-		28.2727690223
1174PhosphorylationLTLSTMDSSTC----
EEEEECCCCCC----		19.4127690223
1175PhosphorylationTLSTMDSSTC-----
EEEECCCCCC-----		29.5427690223
1176PhosphorylationLSTMDSSTC------
EEECCCCCC------		26.6227690223
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AT11B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AT11B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AT11B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CC50A_HUMANTMEM30Aphysical
21914794
IFN21_HUMANIFNA21physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AT11B_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1154, AND MASSSPECTROMETRY.

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