ASXL2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASXL2_MOUSE
• UniProt AC: Q8BZ32
• Protein Name: Putative Polycomb group protein ASXL2
• Gene Name: Asxl2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1370
• Subcellular Localization: Nucleus.
• Protein Description: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3 (By similarity)..
• Protein Sequence: MREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGLKEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSECSEESSDGQSDSHSSDNSSSSDGGSNKEGRKSRWKRKVSSRLSHPPSPPSGCPSPTIPASKVISPSQKHSKKALKQALKQQQQKKKQQQCRPSMSISNQHLSLKTVKAASDSVPAKPGQMKRTKCADIDVETPDSILVNTNLRALINKHTFSVLPGDCQQRLLLLLPEVDRQVGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPEMQVRIRQEIEKEKKVELWKEQFFENYYGQSSGLSLEDSQKLTASSSDPKAKKTPAEQPKSILPSEASPVRIVPVVPQSECKEEAVQIPSPSQKEENQDEARPDSKSPEPVLASASNTNELITMKPIKSPKDEGLLEQKPVACAEQESEKENHVTTTSRNNKSENQEALAISPSKSKNAGLQKPIIKPVAEASPLNPDMKMPPATVTDQIQESLKRKSSLTDEEATSSWEKRPRITENRQHQQPFQVSPQPFLNRGDRVQVRKVPPLKIPVSRISPMLFSTSQVSPRARFPISITSPYRTGARTLADIKAKAQLVEAQKAAAAAAAAAAAAASVGGTIPGPGPGGGQSPREGGERKIAGGGSAGSDPVSTNGKGPTLELAGTGSRGGTRELLPCGPQPETNMPGQAQPPGISGAQLQQTSSVPTGLASSGACTSVPLPAHIEISNSEKPNLHKATATAASPCHLQDPRSCRLEKALSPTGPPLISGASTVYFVADGTVEPKAGSNKNAPKPSALAKTTAPAPLDMTSSPVTTASLEKLPVPQISGTATSTGSAPSSSTLPAASSLKTPGTSANMNGPISRTSSSIPANNPLVTQLLQGKDVPLEQILPKPLTKIEMKTVPLTTKEEKGIGIFPGISVMESSSREEVNGRQAHLAIPQLGKPLQSKQLSQVPRPVFTAKDRKDPCIDTHQYREGLSKTTQDQLFQTLIQRAQRQSVLSFVPPSQFNFAHSGFHLEDISTSQKFMLGFAGRRTSKPAMAGHYLLNISTYGRGTENIKRTHSVNPDDRFCLSSPTEALRMGHADYKNTTGEISSKEDESDEDRVGDEQEPISVKEEPWASQSSGRHPHHGEASSTNDCLASKNGKTEAPVSEQTTLGQENYIFSRGQASDEKSLPRDFIPAAHKQMTHAVRGKTVCSSPELFNSTALSLPADSPTHQPLLLPPLQTPKLYGSPTQIGPSYRGMINVSTSSDMDHNSAIPGSQVSSNVGDVMSFSVTVTTIPASQAMNPSSHGQTIPVQTFPDDNSIEDTPSKCYCRLKAMIMCKGCGAFCHDDCIGPSKLCVSCLVVR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Acetylation	RTWAEAAKTVLEKYP CHHHHHHHHHHHHCC	46.33	22826441
32	Acetylation	PNTPMSHKEILQVIQ CCCCCCHHHHHHHHH	38.86	22826441
51	Phosphorylation	KEIRSGTSPLACLNA HHHHCCCCHHHHHHH	22.80	-
135	Phosphorylation	SRWKRKVSSRLSHPP HHHHHHHHHHCCCCC	16.87	26643407
136	Phosphorylation	RWKRKVSSRLSHPPS HHHHHHHHHCCCCCC	39.98	26643407
139	Phosphorylation	RKVSSRLSHPPSPPS HHHHHHCCCCCCCCC	32.60	25159016
143	Phosphorylation	SRLSHPPSPPSGCPS HHCCCCCCCCCCCCC	54.62	27087446
146	Phosphorylation	SHPPSPPSGCPSPTI CCCCCCCCCCCCCCC	57.31	27087446
150	Phosphorylation	SPPSGCPSPTIPASK CCCCCCCCCCCCHHH	38.46	27087446
152	Phosphorylation	PSGCPSPTIPASKVI CCCCCCCCCCHHHCC	43.88	25159016
156	Phosphorylation	PSPTIPASKVISPSQ CCCCCCHHHCCCCCH	23.31	24759943
160	Phosphorylation	IPASKVISPSQKHSK CCHHHCCCCCHHHHH	22.83	28066266
320	Ubiquitination	QEIEKEKKVELWKEQ HHHHHHHHHHHHHHH	41.87	-
325	Ubiquitination	EKKVELWKEQFFENY HHHHHHHHHHHHHHH	55.02	-
366	Phosphorylation	TPAEQPKSILPSEAS CCCCCCCCCCCCCCC	35.72	28833060
370	Phosphorylation	QPKSILPSEASPVRI CCCCCCCCCCCCCEE	42.20	27566939
373	Phosphorylation	SILPSEASPVRIVPV CCCCCCCCCCEEEEE	21.63	26824392
395	Phosphorylation	EEAVQIPSPSQKEEN HHHCCCCCHHHHHCC	38.52	25521595
397	Phosphorylation	AVQIPSPSQKEENQD HCCCCCHHHHHCCCC	59.21	26643407
412	Phosphorylation	EARPDSKSPEPVLAS CCCCCCCCCCCEEEC	38.15	28066266
434	Phosphorylation	ITMKPIKSPKDEGLL EEECCCCCCCCCCCC	37.59	29472430
461	Phosphorylation	EKENHVTTTSRNNKS HHHCCCCCCCCCCCC	22.99	-
462	Phosphorylation	KENHVTTTSRNNKSE HHCCCCCCCCCCCCC	19.14	-
477	Phosphorylation	NQEALAISPSKSKNA CCEEEEECCCCCCCC	19.95	26824392
479	Phosphorylation	EALAISPSKSKNAGL EEEEECCCCCCCCCC	42.65	22942356
498	Phosphorylation	IKPVAEASPLNPDMK CCCCHHCCCCCCCCC	22.79	28066266
523	Phosphorylation	QESLKRKSSLTDEEA HHHHHHHHCCCHHHH	34.31	25266776
524	Phosphorylation	ESLKRKSSLTDEEAT HHHHHHHCCCHHHHH	38.02	25266776
526	Phosphorylation	LKRKSSLTDEEATSS HHHHHCCCHHHHHHH	43.23	25266776
531	Phosphorylation	SLTDEEATSSWEKRP CCCHHHHHHHHHHCC	26.94	26643407
532	Phosphorylation	LTDEEATSSWEKRPR CCHHHHHHHHHHCCC	40.27	26643407
533	Phosphorylation	TDEEATSSWEKRPRI CHHHHHHHHHHCCCC	34.59	26643407
553	Phosphorylation	HQQPFQVSPQPFLNR CCCCCCCCCCCCCCC	13.66	26370283
590	Phosphorylation	LFSTSQVSPRARFPI EEECCCCCCCCCCCC	10.88	29514104
592	Dimethylation	STSQVSPRARFPISI ECCCCCCCCCCCCCC	30.78	-
594	Methylation	SQVSPRARFPISITS CCCCCCCCCCCCCCC	38.87	24129315
594	Asymmetric dimethylarginine	SQVSPRARFPISITS CCCCCCCCCCCCCCC	38.87	-
601	Phosphorylation	RFPISITSPYRTGAR CCCCCCCCCCCCCCC	20.47	-
638	Phosphorylation	AAAAAAASVGGTIPG HHHHHHHHHCCCCCC	19.30	25619855
642	Phosphorylation	AAASVGGTIPGPGPG HHHHHCCCCCCCCCC	20.33	25619855
653	Phosphorylation	PGPGGGQSPREGGER CCCCCCCCCCCCCCC	29.24	23684622
760	Phosphorylation	KPNLHKATATAASPC CCCCCCCCCCCCCCC	29.37	29472430
762	Phosphorylation	NLHKATATAASPCHL CCCCCCCCCCCCCCC	20.57	23984901
765	Phosphorylation	KATATAASPCHLQDP CCCCCCCCCCCCCCH	26.12	29514104
782	Phosphorylation	CRLEKALSPTGPPLI CCCCHHCCCCCCCCC	25.85	26643407
784	Phosphorylation	LEKALSPTGPPLISG CCHHCCCCCCCCCCC	59.97	26643407
790	Phosphorylation	PTGPPLISGASTVYF CCCCCCCCCCCEEEE	35.67	26643407
793	Phosphorylation	PPLISGASTVYFVAD CCCCCCCCEEEEEEC	23.18	26643407
794	Phosphorylation	PLISGASTVYFVADG CCCCCCCEEEEEECC	20.77	26643407
796	Phosphorylation	ISGASTVYFVADGTV CCCCCEEEEEECCEE	7.76	26643407
833	Phosphorylation	APLDMTSSPVTTASL CCCCCCCCCCEECCH	17.77	25338131
849	Phosphorylation	KLPVPQISGTATSTG HCCCCEEECEECCCC	25.50	22871156
855	Phosphorylation	ISGTATSTGSAPSSS EECEECCCCCCCCCC	30.70	22871156
857	Phosphorylation	GTATSTGSAPSSSTL CEECCCCCCCCCCCC	36.77	22871156
888	Phosphorylation	GPISRTSSSIPANNP CCCCCCCCCCCCCCH	31.51	27600695
965	Acetylation	LAIPQLGKPLQSKQL HHHCCCCCCCCCCCH	51.66	22826441
1072	Phosphorylation	YLLNISTYGRGTENI EEEEECCCCCCCCCC	9.68	28059163
1084	Phosphorylation	ENIKRTHSVNPDDRF CCCCCCCCCCCCCCC	23.99	30387612
1094	Phosphorylation	PDDRFCLSSPTEALR CCCCCCCCCHHHHHH	35.14	29472430
1095	Phosphorylation	DDRFCLSSPTEALRM CCCCCCCCHHHHHHC	23.93	29472430
1097	Phosphorylation	RFCLSSPTEALRMGH CCCCCCHHHHHHCCC	35.52	28066266
1107	Phosphorylation	LRMGHADYKNTTGEI HHCCCCCCCCCCCCC	13.61	-
1110	Phosphorylation	GHADYKNTTGEISSK CCCCCCCCCCCCCCC	31.84	26643407
1111	Phosphorylation	HADYKNTTGEISSKE CCCCCCCCCCCCCCC	42.06	26643407
1115	Phosphorylation	KNTTGEISSKEDESD CCCCCCCCCCCCCCC	30.93	26643407
1116	Phosphorylation	NTTGEISSKEDESDE CCCCCCCCCCCCCCC	45.80	26643407
1121	Phosphorylation	ISSKEDESDEDRVGD CCCCCCCCCCCCCCC	59.63	25521595
1195	Phosphorylation	GQASDEKSLPRDFIP CCCCCCCCCCCCHHH	41.37	27180971
1216	Phosphorylation	THAVRGKTVCSSPEL HHHHCCCEECCCHHH	29.57	26643407
1219	Phosphorylation	VRGKTVCSSPELFNS HCCCEECCCHHHHCC	44.59	26643407
1220	Phosphorylation	RGKTVCSSPELFNST CCCEECCCHHHHCCC	19.78	26643407
1226	Phosphorylation	SSPELFNSTALSLPA CCHHHHCCCCCCCCC	14.02	26643407
1227	Phosphorylation	SPELFNSTALSLPAD CHHHHCCCCCCCCCC	32.49	26643407
1230	Phosphorylation	LFNSTALSLPADSPT HHCCCCCCCCCCCCC	29.82	26643407
1235	Phosphorylation	ALSLPADSPTHQPLL CCCCCCCCCCCCCCC	33.53	26643407
1237	Phosphorylation	SLPADSPTHQPLLLP CCCCCCCCCCCCCCC	36.78	26643407
1248	Phosphorylation	LLLPPLQTPKLYGSP CCCCCCCCCCCCCCC	30.03	26643407
1252	Phosphorylation	PLQTPKLYGSPTQIG CCCCCCCCCCCCCCC	22.99	26239621
1254	Phosphorylation	QTPKLYGSPTQIGPS CCCCCCCCCCCCCCC	15.95	22942356
1256	Phosphorylation	PKLYGSPTQIGPSYR CCCCCCCCCCCCCCC	34.22	28833060
1261	Phosphorylation	SPTQIGPSYRGMINV CCCCCCCCCCCCEEE	23.42	28833060
1262	Phosphorylation	PTQIGPSYRGMINVS CCCCCCCCCCCEEEC	17.83	28833060

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASXL2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASXL2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASXL2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SUZ12_MOUSE	Suz12	physical	24040135
EZH2_MOUSE	Ezh2	physical	24040135

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.