ASTN2_HUMAN - dbPTM
ASTN2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ASTN2_HUMAN
UniProt AC O75129
Protein Name Astrotactin-2
Gene Name ASTN2
Organism Homo sapiens (Human).
Sequence Length 1339
Subcellular Localization Membrane
Multi-pass membrane protein . Perikaryon . Cytoplasm, cell cortex . Early endosome . Late endosome . Cytoplasmic vesicle, clathrin-coated vesicle . Cytoplasmic vesicle . Integral membrane protein not detected at the cell membrane. Detected
Protein Description Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5-bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (Ref.6)..
Protein Sequence MAAAGARLSPGPGSGLRGRPRLCFHPGPPPLLPLLLLFLLLLPPPPLLAGATAAASREPDSPCRLKTVTVSTLPALRESDIGWSGARAGAGAGTGAGAAAAAASPGSPGSAGTAAESRLLLFVRNELPGRIAVQDDLDNTELPFFTLEMSGTAADISLVHWRQQWLENGTLYFHVSMSSSGQLAQATAPTLQEPSEIVEEQMHILHISVMGGLIALLLLLLVFTVALYAQRRWQKRRRIPQKSASTEATHEIHYIPSVLLGPQARESFRSSRLQTHNSVIGVPIRETPILDDYDCEEDEEPPRRANHVSREDEFGSQVTHTLDSLGHPGEEKVDFEKKAAAEATQETVESLMQKFKESFRANTPIEIGQLQPPLRSTSAGKRKRRSKSRGGISFGRAKGTSGSEADDETQLTFYTEQYRSRRRSKGLLKSPVNKTALTLIAVSSCILAMVCGSQMSCPLTVKVTLHVPEHFIADGSSFVVSEGSYLDISDWLNPAKLSLYYQINATSPWVRDLCGQRTTDACEQLCDPETGECSCHEGYAPDPVHRHLCVRSDWGQSEGPWPYTTLERGYDLVTGEQAPEKILRSTFSLGQGLWLPVSKSFVVPPVELSINPLASCKTDVLVTEDPADVREEAMLSTYFETINDLLSSFGPVRDCSRNNGGCTRNFKCVSDRQVDSSGCVCPEELKPMKDGSGCYDHSKGIDCSDGFNGGCEQLCLQQTLPLPYDATSSTIFMFCGCVEEYKLAPDGKSCLMLSDVCEGPKCLKPDSKFNDTLFGEMLHGYNNRTQHVNQGQVFQMTFRENNFIKDFPQLADGLLVIPLPVEEQCRGVLSEPLPDLQLLTGDIRYDEAMGYPMVQQWRVRSNLYRVKLSTITLAAGFTNVLKILTKESSREELLSFIQHYGSHYIAEALYGSELTCIIHFPSKKVQQQLWLQYQKETTELGSKKELKSMPFITYLSGLLTAQMLSDDQLISGVEIRCEEKGRCPSTCHLCRRPGKEQLSPTPVLLEINRVVPLYTLIQDNGTKEAFKSALMSSYWCSGKGDVIDDWCRCDLSAFDANGLPNCSPLLQPVLRLSPTVEPSSTVVSLEWVDVQPAIGTKVSDYILQHKKVDEYTDTDLYTGEFLSFADDLLSGLGTSCVAAGRSHGEVPEVSIYSVIFKCLEPDGLYKFTLYAVDTRGRHSELSTVTLRTACPLVDDNKAEEIADKIYNLYNGYTSGKEQQMAYNTLMEVSASMLFRVQHHYNSHYEKFGDFVWRSEDELGPRKAHLILRRLERVSSHCSSLLRSAYIQSRVETVPYLFCRSEEVRPAGMVWYSILKDTKITCEEKMVSMARNTYGESKGR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
79PhosphorylationTLPALRESDIGWSGA
CCHHHHHCCCCCCCC		28.2623532336
104PhosphorylationGAAAAAASPGSPGSA
HHHHHHCCCCCCCCH		25.6823532336
107PhosphorylationAAAASPGSPGSAGTA
HHHCCCCCCCCHHCH		29.4923532336
150PhosphorylationPFFTLEMSGTAADIS
CEEEEEECCCHHHEE		24.5022167270
152PhosphorylationFTLEMSGTAADISLV
EEEEECCCHHHEEEE		16.0322167270
157PhosphorylationSGTAADISLVHWRQQ
CCCHHHEEEEEEEHH		25.5322167270
168N-linked_GlycosylationWRQQWLENGTLYFHV
EEHHHHHCCEEEEEE		46.72UniProtKB CARBOHYD
245PhosphorylationRIPQKSASTEATHEI
CCCCCCCCCHHHHHH		33.5930576142
246PhosphorylationIPQKSASTEATHEIH
CCCCCCCCHHHHHHE		29.3824719451
254PhosphorylationEATHEIHYIPSVLLG
HHHHHHEECCHHHCC		21.8627642862
278PhosphorylationSRLQTHNSVIGVPIR
HCCCCCCCCCCCCCC		13.9124719451
319PhosphorylationDEFGSQVTHTLDSLG
HHHHHCCCCCHHHCC		11.0828348404
324PhosphorylationQVTHTLDSLGHPGEE
CCCCCHHHCCCCCCC		39.0928348404
344PhosphorylationKKAAAEATQETVESL
HHHHHHHHHHHHHHH		20.6027134283
347PhosphorylationAAEATQETVESLMQK
HHHHHHHHHHHHHHH		21.5429083192
350PhosphorylationATQETVESLMQKFKE
HHHHHHHHHHHHHHH		25.4629083192
358PhosphorylationLMQKFKESFRANTPI
HHHHHHHHHHCCCCE		22.1824719451
388PhosphorylationKRKRRSKSRGGISFG
CCCCCCCCCCCCCCC		37.0924117733
400PhosphorylationSFGRAKGTSGSEADD
CCCCCCCCCCCCCCC		29.2530177828
401PhosphorylationFGRAKGTSGSEADDE
CCCCCCCCCCCCCCH		49.3324719451
403PhosphorylationRAKGTSGSEADDETQ
CCCCCCCCCCCCHHH		29.4030177828
409PhosphorylationGSEADDETQLTFYTE
CCCCCCHHHHHHHHH		35.5530177828
412PhosphorylationADDETQLTFYTEQYR
CCCHHHHHHHHHHHH		12.5530177828
420PhosphorylationFYTEQYRSRRRSKGL
HHHHHHHHHHHCCCC		25.7924719451
430PhosphorylationRSKGLLKSPVNKTAL
HCCCCCCCCCCHHHH		33.7724719451
667AcetylationGGCTRNFKCVSDRQV
CCCCCCCEECCCCEE		36.9622368341
686AcetylationCVCPEELKPMKDGSG
CCCCHHHCCCCCCCC		46.4722368349
754PhosphorylationGKSCLMLSDVCEGPK
CCCEEEHHHCCCCCC		17.6530631047
767PhosphorylationPKCLKPDSKFNDTLF
CCCCCCCCCCCCCHH		47.91-
770N-linked_GlycosylationLKPDSKFNDTLFGEM
CCCCCCCCCCHHHHH		45.13-
783N-linked_GlycosylationEMLHGYNNRTQHVNQ
HHHCCCCCCCCCCCC		39.63UniProtKB CARBOHYD
845PhosphorylationLLTGDIRYDEAMGYP
HHHCCCCHHHHCCCC		20.6128509920
851PhosphorylationRYDEAMGYPMVQQWR
CHHHHCCCCHHEEEE		3.8128509920
861PhosphorylationVQQWRVRSNLYRVKL
HEEEEECCCCEEEEH		28.4728509920
864PhosphorylationWRVRSNLYRVKLSTI
EEECCCCEEEEHHHH		20.0123898821
1015PhosphorylationNRVVPLYTLIQDNGT
CCEECCEEEECCCCC		25.6824114839
1020N-linked_GlycosylationLYTLIQDNGTKEAFK
CEEEECCCCCHHHHH		43.59UniProtKB CARBOHYD
1023UbiquitinationLIQDNGTKEAFKSAL
EECCCCCHHHHHHHH		48.74-
1034PhosphorylationKSALMSSYWCSGKGD
HHHHHHHHHCCCCCC		11.79-
1232PhosphorylationLMEVSASMLFRVQHH
HHHHHHHHHHHHHHH		4.0218691976
1279PhosphorylationRVSSHCSSLLRSAYI
HHHHHHHHHHHHHHH		36.5018691976
1283PhosphorylationHCSSLLRSAYIQSRV
HHHHHHHHHHHHHHC		25.9518691976
1288PhosphorylationLRSAYIQSRVETVPY
HHHHHHHHHCCCCCE		28.8330631047
1312PhosphorylationPAGMVWYSILKDTKI
CCCCHHHHHHCCCCC		13.0124719451
1320PhosphorylationILKDTKITCEEKMVS
HHCCCCCCHHHHHHH		18.54-
1327PhosphorylationTCEEKMVSMARNTYG
CHHHHHHHHHHHHCC		11.8325954137
1336PhosphorylationARNTYGESKGR----
HHHHCCCCCCC----		35.7325954137
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ASTN2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ASTN2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ASTN2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TCPW_HUMANCCT6Bphysical
26186194
TCPD_HUMANCCT4physical
28514442
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ASTN2_HUMAN

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Related Literatures of Post-Translational Modification

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