ARMX2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARMX2_HUMAN
• UniProt AC: Q7L311
• Protein Name: Armadillo repeat-containing X-linked protein 2
• Gene Name: ARMCX2
• Organism: Homo sapiens (Human).
• Sequence Length: 632
• Subcellular Localization: Mitochondrion . Mitochondrion outer membrane ; Single-pass membrane protein .
• Protein Description: May regulate the dynamics and distribution of mitochondria in neural cells..
• Protein Sequence: MSRVRDAGCVAAGIVIGAGAWYCVYKYTRGRDQTKKRMAKPKNRAVAGTGARARAGLRAGFTIDLGSGFSPPTPVRAEAEDRAQDEASALDTVGAEAVAPAASSAEAQSGAGSQAQEADGAGVGPKAESVVGAAMASAIAPPPGVTEALGAAEAPAMAGAPKVAEAPREAETSRAAVPPGTVVPTEAAAPTEVTEGPGVAAPTKVAEAPGVASPTEAAEAPVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKATPGAHTGAIPKATSATGAVPKGGGKGVTRSRNGGKGKGKKSKVEVDELGMGFRPGDGAAAAAAASANGGQAFLAEVPDSEEGESGWTDTESDSDSEPETQRRGRGRRPVAMQKRPFPYEIDEILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQETIRKLGGLPIIANMINKTDPHIKEKALMAMNNLSENYENQGRLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANFFRLLSQGGGKIKVEILKILSNFAENPDMLKKLLSTQVPASFSSLYNSYVESEILINALTLFEIIYDNLRAEVFNYREFNKGSLFYLCTTSGVCVKKIRALANHHDLLVKVKVIKLVNKF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	VIGAGAWYCVYKYTR EEECCCEEEEHHHCC	3.29	-
25	Phosphorylation	AGAWYCVYKYTRGRD CCCEEEEHHHCCCCH	8.50	-
27	Phosphorylation	AWYCVYKYTRGRDQT CEEEEHHHCCCCHHH	5.51	-
42	Acetylation	KKRMAKPKNRAVAGT HHHHCCCCCCCCCCC	59.36	7338401
62	Phosphorylation	AGLRAGFTIDLGSGF CCCCCCCEEECCCCC	16.80	24719451
67	Phosphorylation	GFTIDLGSGFSPPTP CCEEECCCCCCCCCC	43.92	28258704
70	Phosphorylation	IDLGSGFSPPTPVRA EECCCCCCCCCCCCC	33.23	28258704
73	Phosphorylation	GSGFSPPTPVRAEAE CCCCCCCCCCCCHHH	37.49	28258704
181	Phosphorylation	RAAVPPGTVVPTEAA CCCCCCCCCCCCCCC	24.89	25867546
185	Phosphorylation	PPGTVVPTEAAAPTE CCCCCCCCCCCCCCC	27.01	25867546
191	Phosphorylation	PTEAAAPTEVTEGPG CCCCCCCCCCCCCCC	38.06	25867546
194	Phosphorylation	AAAPTEVTEGPGVAA CCCCCCCCCCCCCCC	29.06	25867546
203	Phosphorylation	GPGVAAPTKVAEAPG CCCCCCCCEEECCCC	33.16	25867546
213	Phosphorylation	AEAPGVASPTEAAEA ECCCCCCCCCHHHCC	29.92	29449344
215	Phosphorylation	APGVASPTEAAEAPV CCCCCCCCHHHCCCC	35.44	24719451
225	Phosphorylation	AEAPVPATPTGAAAP HCCCCCCCCCCCCCC	18.47	30108239
227	Phosphorylation	APVPATPTGAAAPTG CCCCCCCCCCCCCCC	34.79	27251275
233	Phosphorylation	PTGAAAPTGAAESPG CCCCCCCCCCCCCCC	34.42	22199227
238	Phosphorylation	APTGAAESPGTSGSP CCCCCCCCCCCCCCC	24.73	30108239
241	Phosphorylation	GAAESPGTSGSPRTA CCCCCCCCCCCCCEE	33.04	30108239
242	Phosphorylation	AAESPGTSGSPRTAV CCCCCCCCCCCCEEE	43.09	27251275
244	Phosphorylation	ESPGTSGSPRTAVVP CCCCCCCCCCEEEEC	15.81	30108239
247	Phosphorylation	GTSGSPRTAVVPGTS CCCCCCCEEEECCCH	27.47	-
253	Phosphorylation	RTAVVPGTSAAKKAT CEEEECCCHHHHCCC	14.77	29214152
254	Phosphorylation	TAVVPGTSAAKKATP EEEECCCHHHHCCCC	31.95	29214152
260	Phosphorylation	TSAAKKATPGAHTGA CHHHHCCCCCCCCCC	31.00	29214152
265	Phosphorylation	KATPGAHTGAIPKAT CCCCCCCCCCCCCCC	27.98	28348404
272	Phosphorylation	TGAIPKATSATGAVP CCCCCCCCCCCCCCC	25.64	-
273	Phosphorylation	GAIPKATSATGAVPK CCCCCCCCCCCCCCC	28.79	-
294	Acetylation	TRSRNGGKGKGKKSK CCCCCCCCCCCCCCC	59.87	164089
296	Acetylation	SRNGGKGKGKKSKVE CCCCCCCCCCCCCEE	71.67	164093
298	Acetylation	NGGKGKGKKSKVEVD CCCCCCCCCCCEEEC	58.31	164175
299	Acetylation	GGKGKGKKSKVEVDE CCCCCCCCCCEEECC	65.27	164097
593	Ubiquitination	FNYREFNKGSLFYLC CCCCCCCCCCEEEEE	56.02	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARMX2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARMX2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARMX2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARMX2_HUMAN	ARMCX2	physical	15383276

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.