ARMX1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARMX1_HUMAN
• UniProt AC: Q9P291
• Protein Name: Armadillo repeat-containing X-linked protein 1
• Gene Name: ARMCX1
• Organism: Homo sapiens (Human).
• Sequence Length: 453
• Subcellular Localization: Mitochondrion . Mitochondrion outer membrane ; Single-pass membrane protein .
• Protein Description: Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1..
• Protein Sequence: MGRTREAGCVAAGVVIGAGACYCVYRLAWGRDENEKIWDEDEESTDTSEIGVETVKGAKTNAGAGSGAKLQGDSEVKPEVSLGLEDCPGVKEKAHSGSHSGGGLEAKAKALFNTLKEQASAKAGKGARVGTISGNRTLAPSLPCPGGRGGGCHPTRSGSRAGGRASGKSKGKARSKSTRAPATTWPVRRGKFNFPYKIDDILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQNAIRELGGVPIIAKLIKTKDPIIREKTYNALNNLSVNAENQGKIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDFFALLFLGNHFTKIQIMKLIINFTENPAMTRELVSCKVPSELISLFNKEWDREILLNILTLFENINDNIKNEGLASSRKEFSRSSLFFLFKESGVCVKKIKALANHNDLVVKVKVLKVLTKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	IWDEDEESTDTSEIG CCCCCCCCCCCCCCC	29.54	27732954
45	Phosphorylation	WDEDEESTDTSEIGV CCCCCCCCCCCCCCE	46.72	22199227
47	Phosphorylation	EDEESTDTSEIGVET CCCCCCCCCCCCEEE	28.48	22199227
48	Phosphorylation	DEESTDTSEIGVETV CCCCCCCCCCCEEEE	29.99	22777824
56	Ubiquitination	EIGVETVKGAKTNAG CCCEEEECCCCCCCC	61.65	-
74	Phosphorylation	GAKLQGDSEVKPEVS CCCCCCCCCCCCCEE	51.63	22199227
81	Phosphorylation	SEVKPEVSLGLEDCP CCCCCCEECCCCCCC	18.30	22199227
96	Phosphorylation	GVKEKAHSGSHSGGG CCCHHCCCCCCCCCH	47.02	-
98	Phosphorylation	KEKAHSGSHSGGGLE CHHCCCCCCCCCHHH	19.93	-
100	Phosphorylation	KAHSGSHSGGGLEAK HCCCCCCCCCHHHHH	40.61	-
131	Phosphorylation	GKGARVGTISGNRTL CCCCEEEEEECCCCC	14.76	28857561
148	Methylation	SLPCPGGRGGGCHPT CCCCCCCCCCCCCCC	46.64	-
157	Phosphorylation	GGCHPTRSGSRAGGR CCCCCCCCCCCCCCC	43.53	23403867
209	Ubiquitination	LSAPDLQKVLNILER HCCCCHHHHHHHHHH	56.86	-
254	Acetylation	GGVPIIAKLIKTKDP CCCCHHHHHHHCCCH	40.09	30587037
266	Ubiquitination	KDPIIREKTYNALNN CCHHHCHHHHHHHHC	46.60	-
366	Phosphorylation	AMTRELVSCKVPSEL HHHHHHHCCCCCHHH	22.35	22468782
451	Phosphorylation	VKVLKVLTKL----- EHHHHHHHCC-----	33.03	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARMX1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARMX1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARMX1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZBT8A_HUMAN	ZBTB8A	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.