ARF6_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARF6_RAT
• UniProt AC: P62332
• Protein Name: ADP-ribosylation factor 6
• Gene Name: Arf6
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 175
• Subcellular Localization: Cytoplasm, cytosol . Cell membrane ; Lipid-anchor . Endosome membrane ; Lipid-anchor . Recycling endosome membrane ; Lipid-anchor . Cell projection, filopodium membrane ; Lipid-anchor . Cell projection, ruffle . Cleavage furrow . Midbody, Midbody ring . G
• Protein Description: GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. [PubMed: 16672654 Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1.]
• Protein Sequence: MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAIILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGKVLSKIF ------CCCHHHHHH	28.87	-
12	Acetylation	LSKIFGNKEMRILML HHHHHCCHHHEEEEE	53.95	22902405
32	Acetylation	GKTTILYKLKLGQSV CCEEEEEEEECCCCE	35.38	29931815
131	Acetylation	QDLPDAMKPHEIQEK CCCCCCCCHHHHHHH	44.97	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARF6_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARF6_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARF6_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PEX3_RAT	Pex3	physical	19686593
ABCD3_RAT	Abcd3	physical	19686593

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.