ABCD3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABCD3_RAT
• UniProt AC: P16970
• Protein Name: ATP-binding cassette sub-family D member 3
• Gene Name: Abcd3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 659
• Subcellular Localization: Peroxisome membrane; Multi-pass membrane protein.
• Protein Description: Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity..
• Protein Sequence: MAAFSKYLTARNSSLAGAAFLLFCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFLSRLSQILKIMVPRTFCKETGYLILIAVMLVSRTYCDVWMIQNGTLIESGIIGRSSKDFKRYLFNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTRYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLLVSGLFLTRLRRPIGKMTIMEQKYEGEYRFVNSRLITNSEEIAFYNGNKREKQTIHSVFRKLVEHLHNFIFFRFSMGFIDSIIAKYIATVVGYLVVSRPFLDLAHPRHLHSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQDKGIEGAQASPLIPGAGEIINADNIIKFDHVPLATPNGDILIQDLSFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGHLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGKEDQKKKGISDQVLKGYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEDYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKKITEDTVEFGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Acetylation	--MAAFSKYLTARNS --CCHHHHHHHHCCC	37.51	55699625
7	Phosphorylation	-MAAFSKYLTARNSS -CCHHHHHHHHCCCH	14.21	25575281
9	Phosphorylation	AAFSKYLTARNSSLA CHHHHHHHHCCCHHH	22.08	25575281
12	N-linked_Glycosylation	SKYLTARNSSLAGAA HHHHHHCCCHHHHHH	33.22	-
13	Phosphorylation	KYLTARNSSLAGAAF HHHHHCCCHHHHHHH	22.60	25575281
14	Phosphorylation	YLTARNSSLAGAAFL HHHHCCCHHHHHHHH	26.28	25575281
61	Acetylation	KERAVVDKVFLSRLS HHHHHHHHHHHHHHH	24.23	22902405
106	N-linked_Glycosylation	CDVWMIQNGTLIESG CCEEEEECCEEEECC	34.20	-
206	N-linked_Glycosylation	SVVDLYSNLSKPFLD HHHHHHHCCCHHHHH	34.47	-
260	Ubiquitination	KMTIMEQKYEGEYRF CCEEEEEECCCCEEE	31.78	-
260	Acetylation	KMTIMEQKYEGEYRF CCEEEEEECCCCEEE	31.78	22902405
349	Phosphorylation	HPRHLHSTHSELLED CCCCCCCCHHHHHHH	20.76	23991683
351	Phosphorylation	RHLHSTHSELLEDYY CCCCCCHHHHHHHHH	29.99	23991683
382	Phosphorylation	VLAGREMTRLAGFTA HHCHHHHHHHHHHHH	20.13	26022182
399	Acetylation	TELMQVLKDLNHGKY HHHHHHHHHCCCCCC	62.40	22902405
424	Phosphorylation	GIEGAQASPLIPGAG CCCCCCCCCCCCCCC	14.25	30240740
529	Acetylation	QVIYPDGKEDQKKKG CEECCCCCHHHHHCC	66.55	22902405
533	Acetylation	PDGKEDQKKKGISDQ CCCCHHHHHCCCCHH	69.63	22902405
538	Phosphorylation	DQKKKGISDQVLKGY HHHHCCCCHHHHHHH	30.56	30181290
543	Acetylation	GISDQVLKGYLDNVQ CCCHHHHHHHHHCCH	46.80	22902405
648	Acetylation	GRGNYEFKKITEDTV CCCCEEEEECCCCCC	31.18	22902405
659	Phosphorylation	EDTVEFGS------- CCCCCCCC-------	42.23	28689409

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ABCD3_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ABCD3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABCD3_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ABCD3_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.