APBB1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APBB1_MOUSE
• UniProt AC: Q9QXJ1
• Protein Name: Amyloid-beta A4 precursor protein-binding family B member 1
• Gene Name: Apbb1
• Organism: Mus musculus (Mouse).
• Sequence Length: 710
• Subcellular Localization: Cell membrane . Cytoplasm . Nucleus . Cell projection, growth cone. Nucleus speckle. Colocalizes with TSHZ3 in the nucleus and in axonal growth cone. Colocalizes with NEK6 at the nuclear speckles (By similarity). In normal conditions, it mainly local
• Protein Description: Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s)..
• Protein Sequence: MSVPSSLSQSAINANSHGGPALSFPLPLHAAHNQLLNAKLQATAVVPKDLRSAMGEGSVPEPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEAETAPLGPKGLMHLYSELELSAHNAANRGLHGSALIINTQEQGPDEGEEKAAGEAEEDDEDEEEEEEEEDLSSPPGLPEPLENVEVPSGPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDTDSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQLTWTGFAHQEGFEEGEFWKDEPSEEAPMELGLKDPEEATLSFPAQSLSPEPVPQEEEKLSQRNANPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMAGGWGEGKDLLLQLEDETLKLVEPQNQTLLHAQPIVSIRVWGVGRDSGSNRDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMSERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQTSTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGSQTP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Ubiquitination	QATAVVPKDLRSAMG CEEEECCHHHHHHHC	58.76	22790023
135	Phosphorylation	ANRGLHGSALIINTQ HHCCCCCCEEEEECC	14.78	22817900
141	Phosphorylation	GSALIINTQEQGPDE CCEEEEECCCCCCCC	24.07	28066266
174	Phosphorylation	EEEEEDLSSPPGLPE HHHHHHCCCCCCCCC	53.79	29899451
205	Phosphorylation	GPREHSKSASLLFGM CCCCCCCCHHHHHCC	26.55	19060867
207	Phosphorylation	REHSKSASLLFGMRN CCCCCCHHHHHCCCC	32.47	29514104
231	Phosphorylation	WATLSQGSPSYGSPE CEECCCCCCCCCCCC	11.75	25338131
340	Phosphorylation	DPEEATLSFPAQSLS CHHHCEEECCCCCCC	25.48	28066266
345	Phosphorylation	TLSFPAQSLSPEPVP EEECCCCCCCCCCCC	32.68	28066266
347	Phosphorylation	SFPAQSLSPEPVPQE ECCCCCCCCCCCCHH	32.25	25521595
402	Phosphorylation	NNCIRQLSYHKNNLH HHHHHHHHHCCCCCC	19.49	28059163
403	Phosphorylation	NCIRQLSYHKNNLHD HHHHHHHHCCCCCCC	25.96	28059163
517	Phosphorylation	RCLVNGLSLDHSKLV HHEECCEECCCHHCC	32.90	22324799
521	Phosphorylation	NGLSLDHSKLVDVPF CCEECCCHHCCCCCE	27.61	22324799
547	Phosphorylation	VQKFQVYYLGNVPVA HHEEEEEEECCCCCC	14.85	15031292
610	Phosphorylation	ECRVRFLSFLAVGRD HHHHHHHHHHHCCCC	18.59	-
666	O-linked_Glycosylation	QKCLDARSQTSTSCL HHHHHCCCCCCCCCC	39.26	55411933
699	Phosphorylation	GVQSLWGSLKPKRLG HHHHHHHCCCCCCCC	22.95	22817900
707	Phosphorylation	LKPKRLGSQTP---- CCCCCCCCCCC----	35.16	22324799
709	Phosphorylation	PKRLGSQTP------ CCCCCCCCC------	32.44	22324799

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
547	Y	Phosphorylation	Kinase	ABL	P00520	PSP
547	Y	Phosphorylation	Kinase	ABL-FAMILY	-	GPS
610	S	Phosphorylation	Kinase	SGK1	Q9WVC6	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
610	S	Phosphorylation	Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APBB1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	8894693
APLP1_HUMAN	APLP1	physical	8894693
APLP2_HUMAN	APLP2	physical	8894693
ENAH_MOUSE	Enah	physical	9407065

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.