APBA1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APBA1_MOUSE
• UniProt AC: B2RUJ5
• Protein Name: Amyloid-beta A4 precursor protein-binding family A member 1
• Gene Name: Apba1
• Organism: Mus musculus (Mouse).
• Sequence Length: 842
• Subcellular Localization: Cytoplasm. Cytoplasm, perinuclear region. Nucleus.; Isoform 3: Golgi apparatus.
• Protein Description: Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of AAP-beta (By similarity)..
• Protein Sequence: MNHLEGSAEVEVADEAPGGEVNESVEADLEHPEVVEGQQPSPSPPPPAGHEPEDHRGHPAPPPPPPPQEEEEEERGECLARSASTESGFHNHTDTAEGDVLAAARDGYEAERAQDADDESAYAVQYRPEAEEYTEQAEAEHVEAAQRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRAEDEPYAEPYADYGGLQEHVYEEIGDAPELEARDGLRLYERERDEAAAYRQEALGARLHHYDERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDLERAPTPGGGHPDSPGLPAPAGQQQRVVGTPGGSEVGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPVDGDSPSPGSSSPLGAESSSIPLHPGDPTEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKTAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQEPMMDHPLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQDGKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
82	Phosphorylation	RGECLARSASTESGF HHCCCHHHCCCCCCC	22.44	27742792
84	Phosphorylation	ECLARSASTESGFHN CCCHHHCCCCCCCCC	33.67	25521595
85	Phosphorylation	CLARSASTESGFHNH CCHHHCCCCCCCCCC	33.61	27742792
87	Phosphorylation	ARSASTESGFHNHTD HHHCCCCCCCCCCCC	47.01	25521595
93	Phosphorylation	ESGFHNHTDTAEGDV CCCCCCCCCCCCCCH	40.12	30372032
95	Phosphorylation	GFHNHTDTAEGDVLA CCCCCCCCCCCCHHH	27.97	26160508
158	Phosphorylation	PNHLHFHSLEHEEAM CCCCCCCCCCCHHHH	34.21	22817900
187	Phosphorylation	HRAEDEPYAEPYADY CCCCCCCCCCCCCCC	22.88	-
191	Phosphorylation	DEPYAEPYADYGGLQ CCCCCCCCCCCCCHH	12.01	-
202	Phosphorylation	GGLQEHVYEEIGDAP CCHHHHHHHHHCCCC	15.11	-
242	Phosphorylation	LGARLHHYDERSDGE HHHHHCCCCCCCCCC	14.57	22324799
246	Phosphorylation	LHHYDERSDGESDSP HCCCCCCCCCCCCCH	48.17	25521595
250	Phosphorylation	DERSDGESDSPEKEA CCCCCCCCCCHHHHH	49.25	25521595
252	Phosphorylation	RSDGESDSPEKEAEF CCCCCCCCHHHHHHC	44.21	25521595
262	Phosphorylation	KEAEFAPYPRMDSYE HHHHCCCCCCCCCCC	10.47	20415495
267	Phosphorylation	APYPRMDSYEQEEDI CCCCCCCCCCCCCCH	22.64	25521595
268	Phosphorylation	PYPRMDSYEQEEDID CCCCCCCCCCCCCHH	19.84	25521595
284	Phosphorylation	IVAEVKQSMSSQSLD HHHHHHHHHCHHHHH	18.21	23737553
286	Phosphorylation	AEVKQSMSSQSLDKA HHHHHHHCHHHHHHH	30.39	25521595
287	Phosphorylation	EVKQSMSSQSLDKAA HHHHHHCHHHHHHHH	18.36	25521595
289	Phosphorylation	KQSMSSQSLDKAAED HHHHCHHHHHHHHHH	40.25	25521595
309	Phosphorylation	QDLERAPTPGGGHPD HHHHHCCCCCCCCCC	33.31	25521595
317	Phosphorylation	PGGGHPDSPGLPAPA CCCCCCCCCCCCCCC	25.89	25521595
333	Phosphorylation	QQQRVVGTPGGSEVG CCCCEEECCCCCHHH	13.72	22324799
337	Phosphorylation	VVGTPGGSEVGQRYS EEECCCCCHHHHHHC	34.72	29899451
344	Phosphorylation	SEVGQRYSKEKRDAI CHHHHHHCHHHHHHH	36.21	25338131
366	Ubiquitination	KEAIEEVKTRTIRSP HHHHHHHHHCCCCCC	35.25	27667366
367	Phosphorylation	EAIEEVKTRTIRSPY HHHHHHHHCCCCCCC	37.92	22324799
369	Phosphorylation	IEEVKTRTIRSPYTP HHHHHHCCCCCCCCC	26.44	19060867
372	Phosphorylation	VKTRTIRSPYTPDEP HHHCCCCCCCCCCCC	20.57	22324799
374	Phosphorylation	TRTIRSPYTPDEPKE HCCCCCCCCCCCCCC	31.95	22324799
375	Phosphorylation	RTIRSPYTPDEPKEP CCCCCCCCCCCCCCC	27.87	25521595
393	Phosphorylation	MRQDISPTRDCDDQR EECCCCCCCCCCCCC	32.14	-
406	Phosphorylation	QRPVDGDSPSPGSSS CCCCCCCCCCCCCCC	32.57	22817900
408	Phosphorylation	PVDGDSPSPGSSSPL CCCCCCCCCCCCCCC	45.93	25521595
411	Phosphorylation	GDSPSPGSSSPLGAE CCCCCCCCCCCCCCC	30.90	25293948
412	Phosphorylation	DSPSPGSSSPLGAES CCCCCCCCCCCCCCC	41.72	25293948
413	Phosphorylation	SPSPGSSSPLGAESS CCCCCCCCCCCCCCC	26.33	22817900
419	Phosphorylation	SSPLGAESSSIPLHP CCCCCCCCCCCCCCC	28.93	25293948
420	Phosphorylation	SPLGAESSSIPLHPG CCCCCCCCCCCCCCC	24.64	25293948
421	Phosphorylation	PLGAESSSIPLHPGD CCCCCCCCCCCCCCC	37.19	25293948
571	Phosphorylation	ARRRMPRSNSQENVE CCCCCCCCCCCCCCC	34.66	27742792
573	Phosphorylation	RRMPRSNSQENVEAS CCCCCCCCCCCCCCC	39.87	25521595
580	Phosphorylation	SQENVEASHPSQDGK CCCCCCCCCCCCCHH	23.56	27742792
599	Phosphorylation	MICHVFESEDAQLIA EEEEEECCHHHHHHH	29.34	20047950
617	Phosphorylation	GQAFSVAYQEFLRAN HHHHHHHHHHHHHHC	13.35	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
187	Y	Phosphorylation	Kinase	SRC	Q9WUD9	PSP
191	Y	Phosphorylation	Kinase	SRC	Q9WUD9	PSP
202	Y	Phosphorylation	Kinase	SRC	Q9WUD9	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APBA1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APBA1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LIPA2_MOUSE	Ppfia2	physical	16186258
CSKP_MOUSE	Cask	physical	9822620

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.