ANM13_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANM13_ARATH
• UniProt AC: Q84W92
• Protein Name: Probable histone-arginine methyltransferase 1.3
• Gene Name: PRMT13
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 535
• Subcellular Localization: Nucleus . Cytoplasm.
• Protein Description: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, and mRNA stability (By similarity). Recruited to promoters upon gene activation, methylates histone H3 and activates transcription via chromatin remodeling. [PubMed: 27676073 Positive regulator in the oxidative stress tolerance that promotes the expression of enzymes preventing oxidative stress such as APX1 and GPX1 by histone methylation (H3R17me2a Confers tolerance to cadmium CdCl(2) and salt NaCl stresses]
• Protein Sequence: MEVSSVKKLEQLEYSLESVTDLSSSSVSSSSPAVATFSYVDGVTELRFLQSDSTHCFNFDLASAQLFKLGPVHFICVSDGSSSSEEKSFSKGVNIKFKNEKDSKDFCESFEEWRNDSVVQGSSLQNGTVSANKSKFDNKIEASSAKMYFHYYGQLLHQQNMLQDYVRTGTYYAAVMENHSDFAGRVVVDVGAGSGILSMFAAQAGAKHVYAVEASEMAEYARKLIAGNPLFADRITVIKGKVEDIELPEKADILISEPMGTLLVNERMLESYVIARDRFMTPKGKMFPTVGRIHMAPFSDEFLFIEMANKAMFWQQQNYYGVDLTPLYGSAHQGYFSQPVVDAFDPRLLVASPMFHMIDFTQMKEEDFYEIDIPLKFTASMCTRMHGLACWFDVLFDGSTVQRWLTTAPGAPTTHWYQIRCVLSQPIYVMAGQEITGRLHLIAHSAQSYTIDLTLSAKMWGPGASQGGILQSSTCKFDLKEPYYRMSQPQAYPVAQEPPLQPQPELSTQQDIQTPNDELEEELLQQLPQNPSAQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEVSSVKK -------CCCCHHHH	11.79	-
215	Phosphorylation	HVYAVEASEMAEYAR EEEEEEHHHHHHHHH	17.88	19880383
507 (in isoform 3)	Phosphorylation	-	23.62	27531888

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANM13_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANM13_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANM13_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANM13_ARATH	PRMT4B	physical	18660432
FRL4A_ARATH	AT3G22440	physical	21798944
ANM14_ARATH	PRMT4A	physical	25293756

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.