| UniProt ID | ANKE1_HUMAN | |
|---|---|---|
| UniProt AC | Q9NU02 | |
| Protein Name | Ankyrin repeat and EF-hand domain-containing protein 1 | |
| Gene Name | ANKEF1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 776 | |
| Subcellular Localization | ||
| Protein Description | ||
| Protein Sequence | MALADKRLENLQIYKVLQCVRNKDKKQIEKLTKLGYPELINYTEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPNPLWALRLHDWSVEREAFLREAFAVLDRGDGSISKNDFVMVLEERQDYASSEQLAAIAHLHEKTRGGGVNINEFFKGTRYLNKSFVLGSYGPKKKEKGMGKKGKKGKFVLPLPICVIPEYAFPRRQDGGPPYYMIETYKNVTDSSRFNRDHPPEHPIQDDSVWYIDDSEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEIKKEEELLSSIYGVPTTSEGKKVQKGNVVHLNSLITSGYTKKVDITFIPRRIWSPEATTAELIRKRELRRERFTHEVDFDDFMMPFQKNITEKARALEAALKT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 15 | Ubiquitination | LENLQIYKVLQCVRN HHHHHHHHHHHHHHC | - | ||
| 102 | Ubiquitination | LSMEILAKAKADMTI HHHHHHHHCCCCEEE | 22817900 | ||
| 103 | Ubiquitination | SMEILAKAKADMTIV HHHHHHHCCCCEEEE | 29967540 | ||
| 104 | Ubiquitination | MEILAKAKADMTIVD HHHHHHCCCCEEEEC | 22817900 | ||
| 108 | Ubiquitination | AKAKADMTIVDNEGK HHCCCCEEEECCCCC | 27667366 | ||
| 173 | Ubiquitination | VCLTFLEKGANPNAI HHHHHHHCCCCCCCC | - | ||
| 182 | Phosphorylation | ANPNAINSSTGRTAL CCCCCCCCCCCHHHH | 22210691 | ||
| 184 | Phosphorylation | PNAINSSTGRTALME CCCCCCCCCHHHHHH | 22210691 | ||
| 193 | Phosphorylation | RTALMEASREGVVEI HHHHHHHHHHCHHHH | 22210691 | ||
| 278 | Ubiquitination | AQRGCDLKWKNLDHK HHCCCCCEECCCCCC | - | ||
| 292 | Ubiquitination | KTPRAVAKEGGFKAA CCHHHHHHHCCHHHH | 29967540 | ||
| 297 | Ubiquitination | VAKEGGFKAASKEIR HHHHCCHHHHHHHHH | 27667366 | ||
| 320 | Ubiquitination | LARPGAKNPNPLWAL HCCCCCCCCCCCEEE | 22817900 | ||
| 321 | Ubiquitination | ARPGAKNPNPLWALR CCCCCCCCCCCEEEE | 22817900 | ||
| 332 | Ubiquitination | WALRLHDWSVEREAF EEEECCCCCHHHHHH | 22817900 | ||
| 337 | Ubiquitination | HDWSVEREAFLREAF CCCCHHHHHHHHHHH | 22817900 | ||
| 410 | Phosphorylation | NKSFVLGSYGPKKKE CCCCCCCCCCCCCCC | 25002506 | ||
| 411 | Phosphorylation | KSFVLGSYGPKKKEK CCCCCCCCCCCCCCC | 25002506 | ||
| 419 | Ubiquitination | GPKKKEKGMGKKGKK CCCCCCCCCCCCCCC | 22817900 | ||
| 434 | Ubiquitination | GKFVLPLPICVIPEY CCEEEEECEEEECHH | 29967540 | ||
| 441 | Phosphorylation | PICVIPEYAFPRRQD CEEEECHHHCCCCCC | 27642862 | ||
| 454 | Phosphorylation | QDGGPPYYMIETYKN CCCCCCEEEEEEECC | 18491316 | ||
| 473 | Ubiquitination | SRFNRDHPPEHPIQD CCCCCCCCCCCCCCC | 27667366 | ||
| 479 | Ubiquitination | HPPEHPIQDDSVWYI CCCCCCCCCCCEEEE | 27667366 | ||
| 485 | Phosphorylation | IQDDSVWYIDDSEKV CCCCCEEEECCCHHH | 27642862 | ||
| 487 | Ubiquitination | DDSVWYIDDSEKVFS CCCEEEECCCHHHHC | 29967540 | ||
| 494 | Phosphorylation | DDSEKVFSNINIITK CCCHHHHCCCEEEEC | 310709033 | ||
| 509 | Ubiquitination | AGDLASLKKAFESGI CCCHHHHHHHHHCCC | 21906983 | ||
| 510 | Ubiquitination | GDLASLKKAFESGIP CCHHHHHHHHHCCCC | 22817900 | ||
| 521 | Ubiquitination | SGIPVDMKDNYYKTP CCCCCCCCCCCCCCC | 22817900 | ||
| 526 | Ubiquitination | DMKDNYYKTPLMTAC CCCCCCCCCCHHHHH | 22817900 | ||
| 572 | Ubiquitination | ACHAGQQDIVELLVE HCCCCCHHHHHHHHH | 22817900 | ||
| 577 | Ubiquitination | QQDIVELLVESGALI CHHHHHHHHHCCCEE | 22817900 | ||
| 608 | Ubiquitination | SCRLDTVKYLLDIGA HCCCCHHHHHHHHCH | 22817900 | ||
| 623 | Ubiquitination | KFQLENRKGHSAMDV HEEEECCCCCCHHHH | 29967540 | ||
| 662 | Ubiquitination | ENQKLKGKTPPILKT HCCCCCCCCCCCCCC | 27667366 | ||
| 668 | Ubiquitination | GKTPPILKTEGPEIK CCCCCCCCCCCCCCC | 27667366 | ||
| 676 | Ubiquitination | TEGPEIKKEEELLSS CCCCCCCHHHHHHHH | 29967540 | ||
| 685 | Phosphorylation | EELLSSIYGVPTTSE HHHHHHHHCCCCCCC | 27642862 | ||
| 694 | Acetylation | VPTTSEGKKVQKGNV CCCCCCCCEEECCCE | 7696105 | ||
| 695 | Acetylation | PTTSEGKKVQKGNVV CCCCCCCEEECCCEE | 7696113 | ||
| 719 | Phosphorylation | YTKKVDITFIPRRIW CCCEEEEEEEECCCC | 19664995 | ||
| 727 | Phosphorylation | FIPRRIWSPEATTAE EEECCCCCCCCCHHH | 27966365 | ||
| 761 | Ubiquitination | DFMMPFQKNITEKAR HHCHHHHHCHHHHHH | 22817900 | ||
| 766 | Ubiquitination | FQKNITEKARALEAA HHHCHHHHHHHHHHH | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ANKE1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ANKE1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ANKE1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KDM1A_HUMAN | KDM1A | physical | 23455924 | |
| JMJD6_HUMAN | JMJD6 | physical | 23455924 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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