AMYP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AMYP_HUMAN
• UniProt AC: P04746
• Protein Name: Pancreatic alpha-amylase
• Gene Name: AMY2A
• Organism: Homo sapiens (Human).
• Sequence Length: 511
• Subcellular Localization: Secreted, extracellular space.
• Protein Sequence: MKFFLLLFTIGFCWAQYSPNTQQGRTSIVHLFEWRWVDIALECERYLAPKGFGGVQVSPPNENVAIYNPFRPWWERYQPVSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVINHMCGNAVSAGTSSTCGSYFNPGSRDFPAVPYSGWDFNDGKCKTGSGDIENYNDATQVRDCRLTGLLDLALEKDYVRSKIAEYMNHLIDIGVAGFRLDASKHMWPGDIKAILDKLHNLNSNWFPAGSKPFIYQEVIDLGGEPIKSSDYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWGFVPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWPRQFQNGNDVNDWVGPPNNNGVIKEVTINPDTTCGNDWVCEHRWRQIRNMVIFRNVVDGQPFTNWYDNGSNQVAFGRGNRGFIVFNNDDWSFSLTLQTGLPAGTYCDVISGDKINGNCTGIKIYVSDDGKAHFSISNSAEDPFIAIHAESKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Pyrrolidone_carboxylic_acid	TIGFCWAQYSPNTQQ HHHHHHHHCCCCCCC	18.10	-
16	Pyrrolidone_carboxylic_acid	TIGFCWAQYSPNTQQ HHHHHHHHCCCCCCC	18.10	11772019
16	Pyrrolidone_carboxylic_acid	TIGFCWAQYSPNTQQ HHHHHHHHCCCCCCC	18.10	11772019
67	Phosphorylation	PNENVAIYNPFRPWW CCCCCEEECCCCCHH	13.67	7938959
77	Phosphorylation	FRPWWERYQPVSYKL CCCHHHHHCCCEEEE	12.97	22461510
81	Phosphorylation	WERYQPVSYKLCTRS HHHHCCCEEEEECCC	24.19	59303295
82	Phosphorylation	ERYQPVSYKLCTRSG HHHCCCEEEEECCCC	14.28	22461510
166	Phosphorylation	GSGDIENYNDATQVR CCCCCCCCCCCCCHH	11.13	-
189	Phosphorylation	DLALEKDYVRSKIAE HHHHCHHHHHHHHHH	14.61	19702290
197	Phosphorylation	VRSKIAEYMNHLIDI HHHHHHHHHHHHHHH	8.32	7095097
273	Phosphorylation	GRVTEFKYGAKLGTV CCEEEEECCCCHHCE	27.86	-
326	Phosphorylation	GHGAGGASILTFWDA CCCCCCCHHHHHHHH	22.77	21299198
476	N-linked_Glycosylation	SGDKINGNCTGIKIY ECCEECCCEEEEEEE	18.71	10769135

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AMYP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AMYP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AMYP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRIA1_HUMAN	TRIAP1	physical	21988832
IGF1R_HUMAN	IGF1R	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.