dbPTM

AML5_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AML5_ARATH
UniProt AC	Q8VWF5
Protein Name	Protein MEI2-like 5
Gene Name	ML5
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	800
Subcellular Localization
Protein Description	Probable RNA-binding protein that plays a role in meiosis and vegetative growth..
Protein Sequence	MDIPHEAEAGAWGILPGFGRHHHPSSDATLFSSSLPVFPRGKLQLSDNRDGFSLIDDTAVSRTNKFNESADDFESHSIGNLLPDEEDLLTGMMDDLDLGELPDADDYDLFGSGGGMELDADFRDNLSMSGPPRLSLSSLGGNAIPQFNIPNGAGTVAGEHPYGEHPSRTLFVRNINSNVEDSELTALFEQYGDIRTLYTTCKHRGFVMISYYDIRSARMAMRSLQNKPLRRRKLDIHFSIPKDNPSEKDMNQGTLVVFNLDPSISNDDLHGIFGAHGEIKEIRETPHKRHHKFVEFYDVRGAEAALKALNRCEIAGKRIKVEPSRPGGARRSLMLQLNQDLENDDLHYLPMIGSPMANSPPMQGNWPLNSPVEGSPLQSVLSRSPVFGLSPTRNGHLSGLASALNSQGPSSKLAPIGRGQIGSNGFQQSSHLFQEPKMDNKYTGNLSPSGPLISNGGGIETLSGSEFLWGSPNARSEPSSSSVWSTSSTGNPLFSTRVDRSVPFPHQHQNQSRSHHHFHVGSAPSGVPLEKHFGFVPESSKDALFMNTVGLQGMSGMGLNGGSFSSKMANNGIINSGSMAENGFSSYRMMSSPRFSPMFLSSGLNPGRFASGFDSLYENGRPRRVENNSNQVESRKQFQLDLEKILNGEDSRTTLMIKNIPNKYTSKMLLAAIDEKNQGTYNFLYLPIDFKNKCNVGYAFINMLNPELIIPFYEAFNGKKWEKFNSEKVASLAYARIQGKSALIAHFQNSSLMNEDMRCRPIIFDTPNNPESVEQVVDEESKNMDLLDSQLSDDDGRERS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	FGRHHHPSSDATLFS CCCCCCCCCCCCCEE	36.17	27643528
26	Phosphorylation	GRHHHPSSDATLFSS CCCCCCCCCCCCEEC	35.40	27643528
29	Phosphorylation	HHPSSDATLFSSSLP CCCCCCCCCEECCCC	33.07	27643528
32	Phosphorylation	SSDATLFSSSLPVFP CCCCCCEECCCCCCC	23.33	27643528
33	Phosphorylation	SDATLFSSSLPVFPR CCCCCEECCCCCCCC	28.67	25368622
34	Phosphorylation	DATLFSSSLPVFPRG CCCCEECCCCCCCCC	35.18	25368622
46	Phosphorylation	PRGKLQLSDNRDGFS CCCEEECCCCCCCCC	21.63	30407730
53	Phosphorylation	SDNRDGFSLIDDTAV CCCCCCCCCCCHHHH	29.91	30291188
77	Phosphorylation	ADDFESHSIGNLLPD CHHHHHCCHHHCCCC	41.28	19376835
127	Phosphorylation	ADFRDNLSMSGPPRL CCHHHCCCCCCCCEE	19.70	25561503
384	Phosphorylation	LQSVLSRSPVFGLSP HHHHHHCCCCCCCCC	23.26	30291188
390	Phosphorylation	RSPVFGLSPTRNGHL CCCCCCCCCCCCCCH	25.30	30291188
392	Phosphorylation	PVFGLSPTRNGHLSG CCCCCCCCCCCCHHH	33.13	19880383
443	Phosphorylation	PKMDNKYTGNLSPSG CCCCCCCCCCCCCCC	22.62	30407730
447	Phosphorylation	NKYTGNLSPSGPLIS CCCCCCCCCCCCEEE	22.48	30407730
449	Phosphorylation	YTGNLSPSGPLISNG CCCCCCCCCCEEECC	50.06	30407730
465	Phosphorylation	GIETLSGSEFLWGSP CEEECCCCCCCCCCC	23.07	30407730
471	Phosphorylation	GSEFLWGSPNARSEP CCCCCCCCCCCCCCC	11.91	30291188
514	Phosphorylation	QHQNQSRSHHHFHVG CCCCCCCCCCEEECC	32.21	25368622
522	Phosphorylation	HHHFHVGSAPSGVPL CCEEECCCCCCCCCC	35.60	30291188
525	Phosphorylation	FHVGSAPSGVPLEKH EECCCCCCCCCCHHH	52.73	25368622
596	Phosphorylation	MMSSPRFSPMFLSSG CCCCCCCCHHHHCCC	19.41	19880383
653	Phosphorylation	LNGEDSRTTLMIKNI HCCCCCCCEEEEECC	28.38	22074104
789	Phosphorylation	KNMDLLDSQLSDDDG CCHHHHHHHCCCCCC	32.75	24601666
792	Phosphorylation	DLLDSQLSDDDGRER HHHHHHCCCCCCCCC	31.21	30291188
800	Phosphorylation	DDDGRERS------- CCCCCCCC-------	39.56	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of AML5_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AML5_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AML5_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SUMO1_ARATH	SUMO1	physical	19151129

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AML5_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks."; Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.; Plant Physiol. 150:889-903(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; SER-77; SER-384;SER-390; SER-522 AND SER-792, AND MASS SPECTROMETRY.	19376835 [Abstract]