ALS2_MOUSE - dbPTM
ALS2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ALS2_MOUSE
UniProt AC Q920R0
Protein Name Alsin
Gene Name Als2
Organism Mus musculus (Mouse).
Sequence Length 1651
Subcellular Localization
Protein Description May act as a GTPase regulator. Controls survival and growth of spinal motoneurons..
Protein Sequence MDSKKKSSTEAEGSKERGLVHVWQAGSFSLTPERLPGWGGKTVLQAALGVRHGVLLTEDGEVYSFGTLPWKSESAEICPSSPLLESALVGHHVITVATGSFHSGAVTESGVVYMWGENAAGQCAVANQQYVPEPSPVSISDSETSPSLAVRILQLACGEEHTLALSLSREIWAWGTGCQLGLITTTFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPPQDLKPVPERCNQCSQLLITMTDKEDHVIISDSHCCPLGVTLSESQAEKHASPAPSPHPEALDEQGEVFENTVVEAELNMGSSQTTSGSAISTQQNVVGTAEVSSARTAPSYPDTHAVTAYLQKLSEHSMRENHEPGEKPPQVQPLVEEAVPDLHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKKVMNFYSTAPCETAAQSGSASTGPESLKDLREEQVKQESLQGKKSSSLMDIREEELEGGSRRLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGSNTFGQLGHSEFPTTVPRLSKVSSENGVWSVAAGQDYSLFLVDTEDFQPGLYYSGRQDRAEGDTLPENPSGTKTPVLLSCSKLGYISRVTAGKDSYLALVDKNIMGYIASLHELASTERRFYSKLSEIKSQILRPLLSLENLGTVTTVQLLQEVASRFSKLCYLIGQHGASLSSYLQGMKEASSLVIMKHSSLFLDSYTEYCTSVSNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNMLFFLPIRRLHNYAKVLLKLATCFEVTSPEYQKLQDSSSCYESLALHLGKKRKEAEYTLSFWKTFPGKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATLWAEPLSEEAGSVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGTSDFPLYGGGSSVQRQEPPISRSAKYTFYKDTRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKALNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPHGDYIEGYFSGEWGSGIKITGTYFKPSLYESDKDKPKAFRKLGNLAVAADEKWRAVFEECWRQLGCESPGQGEVWKAWDNIAVALTTNRRQHKDSPEILSRSQTQTLESLEYIPQHIGAFSVEKYDDIKKYLIKACDTPLHPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGSTIPLSAPLPTGRRSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLYPPLFMLYALDNDREEDIYWECVLRLNKQPDIALLGFLGVQKKFWPATLSILGESKKVLSTTKDACFASAVECLQQISTTFTPSDKLKVIQQTFEEISQSVLASLQEDFLWSMDDLFPVFLYVVLRARIRNLGSEVHLIEDLMDPFLQHGEQGIMFTTLKACYFQIQREKLN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
404O-linked_GlycosylationVGVRVAATYEAGALS
CCHHHEEEEECCCCC		16.5055410813
458PhosphorylationESLQGKKSSSLMDIR
HHHCCCCCCCCHHHC		28.7526643407
459PhosphorylationSLQGKKSSSLMDIRE
HHCCCCCCCCHHHCH		36.0526643407
460PhosphorylationLQGKKSSSLMDIREE
HCCCCCCCCHHHCHH		34.5026824392
473PhosphorylationEEELEGGSRRLSLPG
HHHHCCCCCCCCHHH		25.6926643407
477PhosphorylationEGGSRRLSLPGLLSQ
CCCCCCCCHHHHHHH		30.6124925903
483PhosphorylationLSLPGLLSQVSPRLL
CCHHHHHHHCCHHHH		33.3125521595
486PhosphorylationPGLLSQVSPRLLRKA
HHHHHHCCHHHHHHH		9.1824925903
492SumoylationVSPRLLRKAARVKTR
CCHHHHHHHCCCCCC		46.5028289178
498PhosphorylationRKAARVKTRTVVLTP
HHHCCCCCCEEEECC		28.8126745281
500PhosphorylationAARVKTRTVVLTPTY
HCCCCCCEEEECCCC		21.8720415495
504PhosphorylationKTRTVVLTPTYSGEA
CCCEEEECCCCCCCH		11.2824925903
506PhosphorylationRTVVLTPTYSGEADA
CEEEECCCCCCCHHH		25.6926745281
507PhosphorylationTVVLTPTYSGEADAL
EEEECCCCCCCHHHH		18.8420415495
508PhosphorylationVVLTPTYSGEADALL
EEECCCCCCCHHHHC		32.4120415495
520PhosphorylationALLPSLRTEVWTWGK
HHCHHHEEEEEEECC		39.9446162785
524PhosphorylationSLRTEVWTWGKGKEG
HHEEEEEEECCCCCC		29.5246162791
527AcetylationTEVWTWGKGKEGQLG
EEEEEECCCCCCCCC		59.3723806337
652PhosphorylationENPSGTKTPVLLSCS
CCCCCCCCCEEEEEC		20.6121149613
660UbiquitinationPVLLSCSKLGYISRV
CEEEEECCCCCEEEE		50.7022790023
660UbiquitinationPVLLSCSKLGYISRV
CEEEEECCCCCEEEE		50.7022790023
843UbiquitinationRRLHNYAKVLLKLAT
HHHHHHHHHHHHHHH		24.0522790023
843UbiquitinationRRLHNYAKVLLKLAT
HHHHHHHHHHHHHHH		24.0522790023
850PhosphorylationKVLLKLATCFEVTSP
HHHHHHHHHHCCCCH		28.3228059163
881AcetylationLHLGKKRKEAEYTLS
HHHCCCCCCCEEEEE		70.887712917
891AcetylationEYTLSFWKTFPGKMT
EEEEEEEHHCCCCCC		37.977712929
907 (in isoform 2)Phosphorylation-30.28-
987UbiquitinationISSTPQEKTKWLRAI
ECCCHHHHHHHHHHH		50.5922790023
987UbiquitinationISSTPQEKTKWLRAI
ECCCHHHHHHHHHHH		50.5922790023
1005PhosphorylationVDQALRGTSDFPLYG
HHHHHCCCCCCCCCC		20.7720415495
1006PhosphorylationDQALRGTSDFPLYGG
HHHHCCCCCCCCCCC		39.8320415495
1011PhosphorylationGTSDFPLYGGGSSVQ
CCCCCCCCCCCCCCC		17.6020415495
1015PhosphorylationFPLYGGGSSVQRQEP
CCCCCCCCCCCCCCC		30.5220415495
1016PhosphorylationPLYGGGSSVQRQEPP
CCCCCCCCCCCCCCC		26.0820415495
1067PhosphorylationWPDGKMYSGMFRNGL
CCCCCEECCCCCCCC		21.9328059163
1140PhosphorylationRSGKLTSSSPSMFIG
CCCCCCCCCCCCCCE		40.8229899451
1154UbiquitinationGQWVMDKKAGYGVFD
EEEHHCCCCCCCCCC		42.6622790023
1154UbiquitinationGQWVMDKKAGYGVFD
EEEHHCCCCCCCCCC		42.6622790023
1209PhosphorylationMGNGVLLSEDDTIYE
ECCCEEECCCCCEEE		34.5151459653
1213PhosphorylationVLLSEDDTIYEGEFS
EEECCCCCEEEECCC		37.4751459661
1215PhosphorylationLSEDDTIYEGEFSDD
ECCCCCEEEECCCCC		21.7051459669
1259UbiquitinationKITGTYFKPSLYESD
EEEEEEECHHHHCCC		24.2322790023
1259UbiquitinationKITGTYFKPSLYESD
EEEEEEECHHHHCCC		24.2322790023
1275UbiquitinationDKPKAFRKLGNLAVA
CCCHHHHHHHCHHHH		55.0522790023
1275UbiquitinationDKPKAFRKLGNLAVA
CCCHHHHHHHCHHHH		55.0522790023
1275AcetylationDKPKAFRKLGNLAVA
CCCHHHHHHHCHHHH		55.0519851105
1302PhosphorylationWRQLGCESPGQGEVW
HHHHCCCCCCCCCHH		38.1125521595
1329PhosphorylationNRRQHKDSPEILSRS
CCCCCCCCHHHHCCH		29.2725521595
1336PhosphorylationSPEILSRSQTQTLES
CHHHHCCHHCCCHHH		33.9229899451
1338PhosphorylationEILSRSQTQTLESLE
HHHCCHHCCCHHHHC		25.4323984901
1340PhosphorylationLSRSQTQTLESLEYI
HCCHHCCCHHHHCCC		35.5623984901
1343PhosphorylationSQTQTLESLEYIPQH
HHCCCHHHHCCCCHH		29.6123984901
1346PhosphorylationQTLESLEYIPQHIGA
CCHHHHCCCCHHCCC		24.1623984901
1363AcetylationVEKYDDIKKYLIKAC
EECHHHHHHHHHHHC		42.227744477
1368UbiquitinationDIKKYLIKACDTPLH
HHHHHHHHHCCCCCC		40.1322790023
1368UbiquitinationDIKKYLIKACDTPLH
HHHHHHHHHCCCCCC		40.1322790023
1446PhosphorylationPLPTGRRSFCTGKSD
CCCCCCCCCCCCCCC		24.2623984901
1449PhosphorylationTGRRSFCTGKSDSRS
CCCCCCCCCCCCCCC		45.7123984901
1451UbiquitinationRRSFCTGKSDSRSES
CCCCCCCCCCCCCCC		32.7022790023
1451UbiquitinationRRSFCTGKSDSRSES
CCCCCCCCCCCCCCC		32.7022790023
1452PhosphorylationRSFCTGKSDSRSESP
CCCCCCCCCCCCCCC		42.0123527152
1454PhosphorylationFCTGKSDSRSESPEP
CCCCCCCCCCCCCCC		44.8121082442
1456PhosphorylationTGKSDSRSESPEPGY
CCCCCCCCCCCCCCE		46.5114202007
1458PhosphorylationKSDSRSESPEPGYVV
CCCCCCCCCCCCEEE		35.4923527152
1463PhosphorylationSESPEPGYVVTSSGL
CCCCCCCEEEECCCC		11.4920469934
1466PhosphorylationPEPGYVVTSSGLLLP
CCCCEEEECCCCCHH		13.7126643407
1467PhosphorylationEPGYVVTSSGLLLPV
CCCEEEECCCCCHHH		15.7026643407
1468PhosphorylationPGYVVTSSGLLLPVL
CCEEEECCCCCHHHH		24.8826643407
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ALS2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ALS2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ALS2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SODC_MOUSESod1genetic
20339559
GRIP1_MOUSEGrip1physical
17093100
GRIA2_MOUSEGria2physical
17093100
DLG4_MOUSEDlg4physical
17093100
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ALS2_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-477 AND SER-486, ANDMASS SPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-477, AND MASSSPECTROMETRY.

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