ALP1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALP1_SCHPO
• UniProt AC: Q10197
• Protein Name: Tubulin-folding cofactor D
• Gene Name: alp1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1105
• Subcellular Localization: Cytoplasm, cytoskeleton . Microtubule-associated.
• Protein Description: Has a function in the folding of beta-tubulin. Microtubule-associated protein that is essential to direct polarized cell growth and to position the nucleus and septum to the center of the cell during mitosis..
• Protein Sequence: MEEEESLEGIISIDESLITSRLSQILDDVLDDRSSSHSVEKLKDVAVKYLQFCQFQPTLLDKLLSKYVPNLASYLLKVKNIGKCNSITVILYQFCKIRGYKAVRVLFPVGVQYIKELYTLLNESSNNTWHFHYIVLLWLSQALNTPFPLNSLDDSLDVKKTIYTIAIKYLENSGIDKEASCLVLSRLFSRDDGLDLLLGFLHHCESSWFKRSIFYKIGCLFSLSSFLKICPRNDCLQTVDVAFQFLNVAREDLVGQENSALRKLLCKCYTRLGIVLLPVNSSPNWKYSISNPDSFFQLPDDSNEEVHIYLEVIVDFLLSSVSDIDSFVRWSAAKGLAKIISRLPWNLAEQVIDAIIELMTENMFLNPIENTVNISITSPLVWHGAILFFAKLAGAGLIKYSKCLHILPLIEVGLSYEVRYGTRVTGQSIRDASCYFVWSFYHCYSKSAIEGLQTNLILCLLQTVLFDNEINVRRAATAALFEVIGRHASIPDGLSLISHINYVSVTDISNCYGDLCMKVAHFPQFRSCVFQRLFTNLQHWDVKVQQLSAFSLRQLSIKYPKELSIYLPPILDYLSVGNADFIFGYTIGLASIIGGFLSISFPFDINRIHDLLSHKNLLSLKKFSRQQQTKIILGILKGIQQIFANDIRVDRAFFSEAFSVIIAAIDLQEETIIKDISDAYSVLVKFDDMEETLEVLLDYIRKCSTSKEARIVYIILQNLPNISFRYQKKICKLLLDIYPQLHSIDYQAPVANALQNIIPFTYEKTESIEEFVKELLQVCSNYLTDTRGDVGSWIRKPAMKAISSLLVKDSSGKKLSEDIVWCCISYIIRQTFDKIDSLRGLAYQALEQIRVHYLIRRCEALTNIINRIRNNPNMDGEVLNELNISLLEIPNLRLQAFYGITVFTADGFGSDLAVKCFEFYLSYVYQLEDSFKKSNSRYGKRDLLQLYIDILSSEDEIARFYFPIMKSFTSLLAYGCFTDFQNVKGMSKAIFIVQRRALTCKSPGGLSAILELYRTLFLSKNELLRHHALKYTANLLLNPIEKVRYQAADTLLYAKSIGLLTFLPNELNQKLLTLDWFVPVSQNATFVKQLRNIIQKQIDKLIADR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
122	N-linked_Glycosylation	KELYTLLNESSNNTW HHHHHHHHCCCCCCH	50.66	-
126	N-linked_Glycosylation	TLLNESSNNTWHFHY HHHHCCCCCCHHHHH	60.26	-
373	N-linked_Glycosylation	NPIENTVNISITSPL CCCCCCCCEECCCCH	21.91	-
721	N-linked_Glycosylation	IILQNLPNISFRYQK EECCCCCCCCHHHHH	45.78	-
883	N-linked_Glycosylation	GEVLNELNISLLEIP HHHHHHHCCEEEECC	38.75	-
1083	N-linked_Glycosylation	WFVPVSQNATFVKQL EEEECCCCHHHHHHH	11.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALP1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALP1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALP1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ALP21_SCHPO	alp21	physical	10473641
TBB_SCHPO	nda3	genetic	9450991
ALP21_SCHPO	alp21	physical	23576550
TBCC_SCHPO	tbc1	physical	23576550
ARL_SCHPO	alp41	genetic	23576550

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.