AKND1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AKND1_HUMAN
• UniProt AC: Q5T1N1
• Protein Name: Protein AKNAD1
• Gene Name: AKNAD1
• Organism: Homo sapiens (Human).
• Sequence Length: 836
• Protein Sequence: MDEADFSEHTTYKQEDLPYDGDLSQIKIGNDYSFTSKKDGLEVLNQIIFIADDPQEKAMHSETCGNTAVTIPLGKITENAANKKDEKEKQCTAALHIPANEGDASKSSISDILLHHLSKEPFLRGQGIDCETLPEISNADSFEEEAIIKSIISCYNKNSWPKEQTPELTDQLNPKRDGENSNKPGSATTTEENTSDLEGPVAAGDSSHQENVNVLTKTKGPGDKQKSYQGQSPQKQQTEKANSGNTFKYGQGQVHYQLPDFSKIAPKVKIPKNKIINKPLAIAKQASFSSKSRDKPTLVQDSLETTPESNCVEKQHQEQKGKITEPSQQIQMEPIVHIHQELLTGIESEASLSKLSPTSQKGTSSSSSYIFQKISQGKQMCQKLKEQTDQLKTKVQEFSKRIKQDSPYHLQDKKLVLEKLQGHLELLEQNFLATKDKHLTLQQQVHKHESTIVGDFDPERKVEGEIFKLEMLLEDVKEKMDESKYTSAPSLPVSSPVTLDDLASTFSSLSNEIPKEHPGHPSGPRGSGGSEVTGTPQGGPQEAPNEELCELAPQTYLNGHYGDAAAQNKPDQVAMRLSSNSGEDPNGTPRRQDCAEMTAPSPSCAFCRRLLEWKQNVEKKGHGRINCGRFSIVLHEKAPHSDSTPNSDTGHSFCSDSGTEMQSNKCQDCGTKIPTSRRACRKEPTKEFHYRYNTPGQNYSNHSKRGAFVQPHSLDESKNSSPSFLKPKRICSQRVNSKSFKGEHEPTPGKKKLQAFMTYSSDPATPSPHFYSCRISGSKSLCDFDSTEEIKSEILNSALDHALRTATILKETTDQMIKTIAEDLAKAQRWRNRLKY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	LPYDGDLSQIKIGND CCCCCCHHHEEECCC	34.30	24719451
107	Phosphorylation	NEGDASKSSISDILL CCCCCCCCHHHHHHH	30.34	26604541
181	Phosphorylation	PKRDGENSNKPGSAT CCCCCCCCCCCCCCC	41.76	25332170
189	Phosphorylation	NKPGSATTTEENTSD CCCCCCCCCCCCCCC	31.74	25332170
227	Phosphorylation	GPGDKQKSYQGQSPQ CCCCCCCCCCCCCCC	21.86	46161665
228	Phosphorylation	PGDKQKSYQGQSPQK CCCCCCCCCCCCCCC	24.57	22059455
232	Phosphorylation	QKSYQGQSPQKQQTE CCCCCCCCCCCHHCC	35.80	22964224
262	Phosphorylation	HYQLPDFSKIAPKVK EEECCCHHHHCCCCC	30.45	50564453
297	Phosphorylation	SKSRDKPTLVQDSLE CCCCCCCCCCHHHHC	45.35	68735441
302	Phosphorylation	KPTLVQDSLETTPES CCCCCHHHHCCCCCC	15.83	68735445
306	Phosphorylation	VQDSLETTPESNCVE CHHHHCCCCCCCHHH	18.71	68735449
388	Phosphorylation	CQKLKEQTDQLKTKV HHHHHHHHHHHHHHH	27.14	22798277
399	Phosphorylation	KTKVQEFSKRIKQDS HHHHHHHHHHHHCCC	21.92	46161669
408	Phosphorylation	RIKQDSPYHLQDKKL HHHCCCCCHHCCHHH	21.08	27642862
578	Phosphorylation	DQVAMRLSSNSGEDP CCEEHHHHCCCCCCC	19.67	23403867
579	Phosphorylation	QVAMRLSSNSGEDPN CEEHHHHCCCCCCCC	39.34	23403867
581	Phosphorylation	AMRLSSNSGEDPNGT EHHHHCCCCCCCCCC	45.57	23403867
723	Phosphorylation	ESKNSSPSFLKPKRI CCCCCCCCCCCHHHC	45.20	24719451
819	Phosphorylation	TTDQMIKTIAEDLAK HHHHHHHHHHHHHHH	17.94	113319769

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AKND1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AKND1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AKND1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
DTBP1_HUMAN	DTNBP1	physical	28514442
GT2D1_HUMAN	GTF2IRD1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.