AKAP3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AKAP3_MOUSE
• UniProt AC: O88987
• Protein Name: A-kinase anchor protein 3
• Gene Name: Akap3
• Organism: Mus musculus (Mouse).
• Sequence Length: 864
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, acrosome . Ribs of the fibrous sheath in the principal piece of the sperm tail. Dorsal margin of the acrosomal segment.
• Protein Description: May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction..
• Protein Sequence: MADRVDWLQSQSGVCKVGVYSPGDNQHQDWKMDTSTDPVRVLSWLRKDLEKSTAGFQDSRFKPGESSFVEEVAYPVDQRKGFCVDYYNTTNKGSPGRLHFEMSHKENPSQGLISHVGNGGSIDEVSFYANRLTNLVIAMARKEINEKIHGAENKCVHQSLYMGDEPTPHKSLSTVASELVNETVTACSKNISSDKAPGSGDRASGSSQAPGLRYTSTLKIKESTKEGKCPDDKPGTKKSFFYKEVFESRNAGDAKEGGRSLPGDQKLFRTSPDNRPDDFSNSISQGIMTYANSVVSDMMVSIMKTLKIQVKDTTIATILLKKVLMKHAKEVVSDLIDSFMKNLHGVTGSLMTDTDFVSAVKRSFFSHGSQKATDIMDAMLGKLYNVMFAKKFPENIRRARDKSESYSLISTKSRAGDPKLSNLNFAMKSESKLKENLFSTCKLEKEKTCAETLGEHIIKEGLHMWHKSQQKSPGLERAAKLGNAPQEVSFECPDPCEANPPHQPQPPENFANFMCDSDSWAKDLIVSALLLIQYHLAQGGKMDAQSFLEAAASTNFPTNKPPPPSPVVQDECKLKSPPHKICDQEQTEKKDLMSVIFNFIRNLLSETIFKSSRNCESNVHEQNTQEEEIHPCERPKTPCERPITPPAPKFCEDEEATGGALSGLTKMVANQLDNCMNGQMVEHLMDSVMKLCLIIAKSCDSPLSELGEEKCGDASRPNSAFPDNLYECLPVKGTGTAEALLQNAYLTIHNELRGLSGQPPEGCEIPKVIVSNHNLADTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSATAVEKGRSVGEVLQSVLRYEKERQLDEAVGNVTRLQLLDWLMANL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	DRVDWLQSQSGVCKV CHHHHHHHCCCCEEE	24.92	25293948
12	Phosphorylation	VDWLQSQSGVCKVGV HHHHHHCCCCEEEEE	38.14	25293948
43	Phosphorylation	TDPVRVLSWLRKDLE CCHHHHHHHHHHHHH	22.62	27180971
66	Phosphorylation	SRFKPGESSFVEEVA CCCCCCCCCHHEEEC	34.68	25293948
67	Phosphorylation	RFKPGESSFVEEVAY CCCCCCCCHHEEECC	29.07	25293948
89	Phosphorylation	FCVDYYNTTNKGSPG EEEEEEECCCCCCCC	18.67	25293948
90	Phosphorylation	CVDYYNTTNKGSPGR EEEEEECCCCCCCCE	31.15	25293948
94	Phosphorylation	YNTTNKGSPGRLHFE EECCCCCCCCEEEEE	26.28	25293948
103	Phosphorylation	GRLHFEMSHKENPSQ CEEEEEECCCCCCCC	24.98	28418008
109	Phosphorylation	MSHKENPSQGLISHV ECCCCCCCCCCCCCC	48.76	25293948
114	Phosphorylation	NPSQGLISHVGNGGS CCCCCCCCCCCCCCC	19.70	25293948
121	Phosphorylation	SHVGNGGSIDEVSFY CCCCCCCCHHHHHHH	28.41	25293948
171	Phosphorylation	DEPTPHKSLSTVASE CCCCCCCCHHHHHHH	25.23	25293948
173	Phosphorylation	PTPHKSLSTVASELV CCCCCCHHHHHHHHH	28.11	25293948
174	Phosphorylation	TPHKSLSTVASELVN CCCCCHHHHHHHHHH	25.94	25293948
177	Phosphorylation	KSLSTVASELVNETV CCHHHHHHHHHHHHH	27.42	25293948
206	Phosphorylation	SGDRASGSSQAPGLR CCCCCCCCCCCCCCE	19.44	-
403	Phosphorylation	IRRARDKSESYSLIS HHHHHHCCCCCCEEC	35.74	103260593
405	Phosphorylation	RARDKSESYSLISTK HHHHCCCCCCEECCC	27.41	27180971
406	Phosphorylation	ARDKSESYSLISTKS HHHCCCCCCEECCCC	11.93	-
407	Phosphorylation	RDKSESYSLISTKSR HHCCCCCCEECCCCC	28.62	28059163
421	Phosphorylation	RAGDPKLSNLNFAMK CCCCCCHHCCCHHCC	45.45	27180971
565	Phosphorylation	TNKPPPPSPVVQDEC CCCCCCCCCCCCCCC	35.78	25293948
576	Phosphorylation	QDECKLKSPPHKICD CCCCCCCCCCCCCCC	54.84	103260599
637	Phosphorylation	HPCERPKTPCERPIT CCCCCCCCCCCCCCC	35.53	25293948
644	Phosphorylation	TPCERPITPPAPKFC CCCCCCCCCCCCCCC	26.38	25293948
698	Phosphorylation	LCLIIAKSCDSPLSE HHHHHHHHCCCCHHH	17.71	25293948
701	Phosphorylation	IIAKSCDSPLSELGE HHHHHCCCCHHHHCC	31.87	25293948
704	Phosphorylation	KSCDSPLSELGEEKC HHCCCCHHHHCCCCC	33.87	25293948
715	Phosphorylation	EEKCGDASRPNSAFP CCCCCCCCCCCCCCC	53.67	25293948
719	Phosphorylation	GDASRPNSAFPDNLY CCCCCCCCCCCCCHH	33.69	25293948
771	Phosphorylation	EIPKVIVSNHNLADT CCCCEEECCCCHHHH	22.65	27180971
827	Phosphorylation	TAVEKGRSVGEVLQS HHHHHCCCHHHHHHH	43.04	25293948
838	Phosphorylation	VLQSVLRYEKERQLD HHHHHHHHHHHHHHH	27.48	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AKAP3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AKAP3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AKAP3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BRAP_MOUSE	Brap	physical	25820252

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.