AIM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AIM2_HUMAN
• UniProt AC: O14862
• Protein Name: Interferon-inducible protein AIM2
• Gene Name: AIM2
• Organism: Homo sapiens (Human).
• Sequence Length: 343
• Subcellular Localization: Nucleus. Cytoplasm. Activated inflammasomes can aggregate in the cytosol as speck-like particles.
• Protein Description: Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity..
• Protein Sequence: MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVSAVMKTIRIFQKLNYMLLAKRLQEEKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAKQRAAPKVSPHVKPEQKQMVAQQESIREGFQKRCLPVMVLKAKKPFTFETQEGKQEMFHATVATEKEFFFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPLNIIRKAGETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRNEDTMKCKEGDKVRLTFFTLSKNGEKLQLTSGVHSTIKVIKAKKKT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Ubiquitination	EFNIATGKLHTANRI CCCCCCCCCCCCCCH	32.51	-
50	Phosphorylation	ANRIQVATLMIQNAG CCCHHHEEEHHHCCC	20.29	30266825
60	Phosphorylation	IQNAGAVSAVMKTIR HHCCCHHHHHHHHHH	18.01	30266825
64	"N6,N6-dimethyllysine"	GAVSAVMKTIRIFQK CHHHHHHHHHHHHHH	33.91	-
64	Methylation	GAVSAVMKTIRIFQK CHHHHHHHHHHHHHH	33.91	-
71	Acetylation	KTIRIFQKLNYMLLA HHHHHHHHHHHHHHH	28.13	30586813
74	Phosphorylation	RIFQKLNYMLLAKRL HHHHHHHHHHHHHHH	10.28	24260401
79	Acetylation	LNYMLLAKRLQEEKE HHHHHHHHHHHHHHH	54.32	30586819
85	Acetylation	AKRLQEEKEKVDKQY HHHHHHHHHHHHHHH	63.18	30586825
107	Phosphorylation	PLSQAEMSPAASAAI CCCHHHCCHHHHHHH	11.68	26714015
128	Phosphorylation	QRAAPKVSPHVKPEQ HHCCCCCCCCCCHHH	18.53	26714015
160	Acetylation	CLPVMVLKAKKPFTF CEEEEEEEECCCEEE	46.91	7977147
235	Ubiquitination	LDAESDQKVNVPLNI ECCCCCCCCCCCHHH	40.54	-
254	Phosphorylation	GETPKINTLQTQPLG CCCCCCCCCCCCCCC	24.58	50564277
257	Phosphorylation	PKINTLQTQPLGTIV CCCCCCCCCCCCEEC	34.95	50564285
262	Phosphorylation	LQTQPLGTIVNGLFV CCCCCCCEECCCEEE	29.45	46161057
285	Phosphorylation	KNILFDLSDNTGKME CCEEEECCCCCCCEE	30.56	26074081
288	Phosphorylation	LFDLSDNTGKMEVLG EEECCCCCCCEEEEE	43.07	26074081
301	Phosphorylation	LGVRNEDTMKCKEGD EEEECCCCCCCCCCC	16.61	26074081
327	Phosphorylation	NGEKLQLTSGVHSTI CCCEEEEECCCCHHH	15.52	29978859
328	Phosphorylation	GEKLQLTSGVHSTIK CCEEEEECCCCHHHE	47.62	29978859
332	Phosphorylation	QLTSGVHSTIKVIKA EEECCCCHHHEEECC	29.44	29978859
333	Phosphorylation	LTSGVHSTIKVIKAK EECCCCHHHEEECCC	15.22	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AIM2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AIM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AIM2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APBP2_HUMAN	APPBP2	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.