ADH4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADH4_HUMAN
• UniProt AC: P08319
• Protein Name: Alcohol dehydrogenase 4
• Gene Name: ADH4
• Organism: Homo sapiens (Human).
• Sequence Length: 380
• Subcellular Localization: Cytoplasm.
• Protein Sequence: MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEGLAFPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNLKSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGCGFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKALGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFIGVAAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDALVTHTLPFDKISEAFDLMNQGKSVRTILIF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	VRIQIIATSLCHTDA EEEEEEEEECCCCCC	16.30	29759185
45	Phosphorylation	RIQIIATSLCHTDAT EEEEEEEECCCCCCE	21.70	29759185
49	Phosphorylation	IATSLCHTDATVIDS EEEECCCCCCEEECC	26.74	29759185
52	Phosphorylation	SLCHTDATVIDSKFE ECCCCCCEEECCCCC	22.32	29759185
56	Phosphorylation	TDATVIDSKFEGLAF CCCEEECCCCCCCCC	28.28	29759185
77	Phosphorylation	EAAGIVESIGPGVTN HHHHHHHHHCCCCCC	23.19	24275569
83	Phosphorylation	ESIGPGVTNVKPGDK HHHCCCCCCCCCCCE	39.96	69013467
95	Phosphorylation	GDKVIPLYAPLCRKC CCEEEEEEHHHHCCC	10.79	46159793
117	Phosphorylation	TNLCGKISNLKSPAS HHHHHHHHCCCCCCC	39.33	50563765
120	Methylation	CGKISNLKSPASDQQ HHHHHCCCCCCCHHH	59.66	-
121	Phosphorylation	GKISNLKSPASDQQL HHHHCCCCCCCHHHH	28.94	24275569
124	Phosphorylation	SNLKSPASDQQLMED HCCCCCCCHHHHHCC	39.06	22798277
133	Phosphorylation	QQLMEDKTSRFTCKG HHHHCCCCCCEEECC	37.14	50563771
144	Phosphorylation	TCKGKPVYHFFGTST EECCCEEEEECCCCC	11.05	7472215
218	Acetylation	LSAVMGCKAAGASRI HHHHHCCHHCCCCEE	35.23	24889035
254	Acetylation	LNPRDLHKPIQEVII CCHHHCCCCHHHHHH	51.63	20167786
278	Phosphorylation	ALDCAGGSETMKAAL EEECCCCCHHHHHHH	29.04	20166139
280	Phosphorylation	DCAGGSETMKAALDC ECCCCCHHHHHHHCC	26.18	20166139
330	Phosphorylation	TFFGGWKSVDSIPKL EEECCCCCHHCCCCH	25.34	28258704
333	Phosphorylation	GGWKSVDSIPKLVTD CCCCCHHCCCCHHHC	38.34	25072903
342	Acetylation	PKLVTDYKNKKFNLD CCHHHCCCCCCCCHH	66.17	24885193
355	Phosphorylation	LDALVTHTLPFDKIS HHHEEEECCCHHHHH	27.10	46159787
362	Phosphorylation	TLPFDKISEAFDLMN CCCHHHHHHHHHHHH	28.72	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADH4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADH4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADH4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
RL35_HUMAN	RPL35	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00898: Ethanol