dbPTM

ADH1B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ADH1B_HUMAN
UniProt AC	P00325
Protein Name	Alcohol dehydrogenase 1B
Gene Name	ADH1B
Organism	Homo sapiens (Human).
Sequence Length	375
Subcellular Localization	Cytoplasm.
Protein Description
Protein Sequence	MSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSTAGKVIK ------CCCCCCEEE	27.28	6391920
11	Glycation	AGKVIKCKAAVLWEV CCCEEEECEEEEEEE	34.09	-
23	Phosphorylation	WEVKKPFSIEDVEVA EEECCCCCCCEEEEC	33.33	20166139
35	Phosphorylation	EVAPPKAYEVRIKMV EECCCCCEEEEEEEE	22.53	10733556
40	Glycation	KAYEVRIKMVAVGIC CCEEEEEEEEEEEEE	19.43	-
55	Phosphorylation	RTDDHVVSGNLVTPL CCCCCEEECCEECCC	22.37	24275569
76	Phosphorylation	EAAGIVESVGEGVTT HHHCCEEECCCCCEE	25.24	22468782
82	Phosphorylation	ESVGEGVTTVKPGDK EECCCCCEEECCCCE	36.41	22468782
83	Phosphorylation	SVGEGVTTVKPGDKV ECCCCCEEECCCCEE	24.91	22468782
100	Acetylation	LFTPQCGKCRVCKNP EECCCCCCCEECCCC	26.88	24888345
109	Phosphorylation	RVCKNPESNYCLKND EECCCCCCCEEEECC	34.06	29978859
111	Phosphorylation	CKNPESNYCLKNDLG CCCCCCCEEEECCCC	14.40	21253578
150	Phosphorylation	GTSTFSQYTVVDENA CCCCCCEEEEECCCC	10.58	21253578
151	Phosphorylation	TSTFSQYTVVDENAV CCCCCEEEEECCCCE	13.35	30814717
165	Phosphorylation	VAKIDAASPLEKVCL EEEEECCCCCCEEEE	31.57	22798277
179	Phosphorylation	LIGCGFSTGYGSAVN EECCCCCCCCCCEEE	31.96	-
181	Phosphorylation	GCGFSTGYGSAVNVA CCCCCCCCCCEEEEE	14.16	-
213	Acetylation	LSAVMGCKAAGAARI HHHHHCCHHHCCEEE	35.23	24889021
232	Glycation	INKDKFAKAKELGAT CCHHHHHHHHHHCCC	64.22	-
239	Phosphorylation	KAKELGATECINPQD HHHHHCCCCCCCHHH	29.59	22798277
247	Phosphorylation	ECINPQDYKKPIQEV CCCCHHHHCHHHHHH	18.70	-
249	Glycation	INPQDYKKPIQEVLK CCHHHHCHHHHHHHH	40.92	-
320	Phosphorylation	RTWKGAVYGGFKSKE CCCCCCCCCCCCCCC	15.82	20561345
326	Glycation	VYGGFKSKEGIPKLV CCCCCCCCCCHHHHH	61.62	-
331	Acetylation	KSKEGIPKLVADFMA CCCCCHHHHHHHHHH	54.39	27178108
339	Acetylation	LVADFMAKKFSLDAL HHHHHHHHHCCHHHH	42.43	7666867
340	Acetylation	VADFMAKKFSLDALI HHHHHHHHCCHHHHH	30.55	27178108
342	Phosphorylation	DFMAKKFSLDALITH HHHHHHCCHHHHHHH	33.93	20166139
355	Acetylation	THVLPFEKINEGFDL HHCCCHHHHCCCCCE	51.73	20167786
365	Phosphorylation	EGFDLLHSGKSIRTV CCCCEECCCCCCEEE	48.13	20166139
367	Acetylation	FDLLHSGKSIRTVLT CCEECCCCCCEEEEE	45.80	24885157

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ADH1B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ADH1B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
2	Acetylation	8 (6)	H ⇒ P;R	rs1229984	Esophageal cancer Oral cavity and pharyngeal cancer Alcohol dependence Alcohol consumption	19698717 21437268 23456092 23743675 27749845 28485404 28135244 28892062 24166409
320	Phosphorylation	330 (10)	R ⇒ C	rs2066702	Alcohol dependence	24166409
331	Acetylation	330 (1)	R ⇒ C	rs2066702	Alcohol dependence	24166409
339	Acetylation	330 (9)	R ⇒ C	rs2066702	Alcohol dependence	24166409
340	Acetylation	330 (10)	R ⇒ C	rs2066702	Alcohol dependence	24166409
365	Phosphorylation	370 (5)	R ⇒ C	rs2066702	Alcohol dependence	24166409
367	Acetylation	370 (3)	R ⇒ C	rs2066702	Alcohol dependence	24166409

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYOME_HUMAN	PDE4DIP	physical	21988832
RACK1_HUMAN	GNB2L1	physical	21988832
AACT_HUMAN	SERPINA3	physical	21988832
PML_HUMAN	PML	physical	21988832
IRAK3_HUMAN	IRAK3	physical	21988832

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00898	Ethanol
DB01213	Fomepizole

Regulatory Network of ADH1B_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Human liver alcohol dehydrogenase. 1. The primary structure of thebeta 1 beta 1 isoenzyme."; Hempel J., Buhler R., Kaiser R., Holmquist B., de Zalenski C.,von Wartburg J.-P., Vallee B.L., Joernvall H.; Eur. J. Biochem. 145:437-445(1984). Cited for: PROTEIN SEQUENCE OF 2-375.	6391920 [Abstract]