ADAT3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADAT3_HUMAN
• UniProt AC: Q96EY9
• Protein Name: Probable inactive tRNA-specific adenosine deaminase-like protein 3
• Gene Name: ADAT3
• Organism: Homo sapiens (Human).
• Sequence Length: 351
• Protein Sequence: MEPAPGLVEQPKCLEAGSPEPEPAPWQALPVLSEKQSGDVELVLAYAAPVLDKRQTSRLLKEVSALHPLPAQPHLKRVRPSRDAGSPHALEMLLCLAGPASGPRSLAELLPRPAVDPRGLGQPFLVPVPARPPLTRGQFEEARAHWPTSFHEDKQVTSALAGRLFSTQERAAMQSHMERAVWAARRAAARGLRAVGAVVVDPASDRVLATGHDCSCADNPLLHAVMVCVDLVARGQGRGTYDFRPFPACSFAPAAAPQAVRAGAVRKLDADEDGLPYLCTGYDLYVTREPCAMCAMALVHARILRVFYGAPSPDGALGTRFRIHARPDLNHRFQVFRGVLEEQCRWLDPDT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEPAPGLV -------CCCCCCCC	14.54	19413330
18	Phosphorylation	PKCLEAGSPEPEPAP CCCCCCCCCCCCCCC	32.89	25850435
33	Phosphorylation	WQALPVLSEKQSGDV CCCCCCCCCCCCCCE	42.87	50563667
34	Phosphorylation	QALPVLSEKQSGDVE CCCCCCCCCCCCCEE	51.45	27251275
77	Ubiquitination	PAQPHLKRVRPSRDA CCCCCHHCCCCCCCC	35.72	-
86	Phosphorylation	RPSRDAGSPHALEML CCCCCCCCHHHHHHH	18.42	24719451
102	Phosphorylation	CLAGPASGPRSLAEL HHHCCCCCCHHHHHH	24.60	-
166	Phosphorylation	ALAGRLFSTQERAAM HHHHHHHCHHHHHHH	33.50	24719451
167	Phosphorylation	LAGRLFSTQERAAMQ HHHHHHCHHHHHHHH	27.41	17525332
175	Phosphorylation	QERAAMQSHMERAVW HHHHHHHHHHHHHHH	16.24	24719451
183	Phosphorylation	HMERAVWAARRAAAR HHHHHHHHHHHHHHH	5.63	17525332

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADAT3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADAT3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADAT3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
THB_HUMAN	THRB	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615286: Mental retardation, autosomal recessive 36 (MRT36)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
PubMed: 19413330

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-167, AND MASSSPECTROMETRY.
PubMed: 17525332