ADA2C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADA2C_HUMAN
• UniProt AC: P18825
• Protein Name: Alpha-2C adrenergic receptor
• Gene Name: ADRA2C
• Organism: Homo sapiens (Human).
• Sequence Length: 462
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins..
• Protein Sequence: MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	N-linked_Glycosylation	VAAAAGPNASGAGER HHHHHCCCCCCCCCC	45.91	UniProtKB CARBOHYD
33	N-linked_Glycosylation	RGSGGVANASGASWG CCCCCCCCCCCCCCC	32.03	UniProtKB CARBOHYD
330	Phosphorylation	AGPGAAESGALTASR CCCCHHHCCCEECCC	25.33	22210691
334	Phosphorylation	AAESGALTASRSPGP HHHCCCEECCCCCCC	23.27	23312004
336	Phosphorylation	ESGALTASRSPGPGG HCCCEECCCCCCCCC	28.23	29414761
338	Phosphorylation	GALTASRSPGPGGRL CCEECCCCCCCCCCC	31.54	30624053
349	Phosphorylation	GGRLSRASSRSVEFF CCCCCCHHHHCHHHH	25.77	23312004
350	Phosphorylation	GRLSRASSRSVEFFL CCCCCHHHHCHHHHH	27.82	23312004
352	Phosphorylation	LSRASSRSVEFFLSR CCCHHHHCHHHHHHH	28.13	22617229
358	Phosphorylation	RSVEFFLSRRRRARS HCHHHHHHHHHHHHH	20.70	55446137
366	Phosphorylation	RRRRARSSVCRRKVA HHHHHHHHHHHHHHH	21.49	22798277

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADA2C_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADA2C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADA2C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EI2BA_HUMAN	EIF2B1	physical	9235896
UCHL1_HUMAN	UCHL1	physical	19477270

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.