dbPTM

ACTB_RABIT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ACTB_RABIT
UniProt AC	P29751
Protein Name	Actin, cytoplasmic 1
Gene Name	ACTB
Organism	Oryctolagus cuniculus (Rabbit).
Sequence Length	375
Subcellular Localization	Cytoplasm, cytoskeleton. Localized in cytoplasmic mRNP granules containing untranslated mRNAs..
Protein Description	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells..
Protein Sequence	MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEERPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDDDIAAL -------CCCCCEEE	13.23	-
2	Acetylation	------MDDDIAALV ------CCCCCEEEE	63.39	-
44	Oxidation	RPRHQGVMVGMGQKD CCCCCCEEEECCCCC	2.49	-
47	Oxidation	HQGVMVGMGQKDSYV CCCEEEECCCCCCCC	3.32	-
73	Methylation	TLKYPIEHGIVTNWD EEECEECCCCCCCHH	31.81	-
84	Methylation	TNWDDMEKIWHHTFY CCHHHHHHHHHHHHH	44.45	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ACTB_RABIT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ACTB_RABIT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ACTB_RABIT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
ACTB_RABIT	ACTB	physical	15328537

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ACTB_RABIT

Related Literatures of Post-Translational Modification