ACT5_DROME - dbPTM
ACT5_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ACT5_DROME
UniProt AC P10981
Protein Name Actin-87E
Gene Name Act87E
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 376
Subcellular Localization Cytoplasm, cytoskeleton.
Protein Description Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.; Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction..
Protein Sequence MCDDEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNAPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAAASTSLEKSYELPDGQVITIGNERFRCPESLFQPSFLGMESCGIHETVYNSIMKCDVDIRKDLYANIVMSGGTTMYPGIADRMQKEITALAPSTIKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPGIVHRKCF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
3Acetylation-----MCDDEVAALV
-----CCCCCCEEEE
54.53-
34PhosphorylationAPRAVFPSIVGRPRH
CCCCCCHHHCCCCCC
20.5922817900
45Methionine sulfoxideRPRHQGVMVGMGQKD
CCCCCCEEEECCCCC
2.49-
45OxidationRPRHQGVMVGMGQKD
CCCCCCEEEECCCCC
2.4922116028
48Methionine sulfoxideHQGVMVGMGQKDSYV
CCCEEEECCCCCCCC
3.32-
48OxidationHQGVMVGMGQKDSYV
CCCEEEECCCCCCCC
3.3222116028
51AcetylationVMVGMGQKDSYVGDE
EEEECCCCCCCCCCH
42.8019608861
53PhosphorylationVGMGQKDSYVGDEAQ
EECCCCCCCCCCHHH
28.8421082442
61PhosphorylationYVGDEAQSKRGILTL
CCCCHHHCCCCEEEE
31.2227794539
67PhosphorylationQSKRGILTLKYPIEH
HCCCCEEEEECEECC
21.2022668510
69AcetylationKRGILTLKYPIEHGI
CCCEEEEECEECCCC
43.6919608861
74MethylationTLKYPIEHGIITNWD
EEECEECCCCCCCHH
33.2130526847
107PhosphorylationEEHPVLLTEAPLNPK
CCCCEEEEECCCCCC
26.4122817900
192AcetylationDLTDYLMKILTERGY
CHHHHHHHHHHHCCC
31.7819608861
241PhosphorylationSTSLEKSYELPDGQV
HCCCHHHEECCCCCE
32.3329892262
324PhosphorylationEITALAPSTIKIKII
HHHHHCCCEEEEEEE
36.8427794539
325PhosphorylationITALAPSTIKIKIIA
HHHHCCCEEEEEEEC
25.8227794539
329AcetylationAPSTIKIKIIAPPER
CCCEEEEEEECCCCC
24.0619608861

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ACT5_DROME !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ACT5_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ACT5_DROME !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CADF_DROMEtsrphysical
14605208
CPN_DROMECpnphysical
14605208
TAP_DROMEtapphysical
14605208

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ACT5_DROME

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Related Literatures of Post-Translational Modification

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