ACR4L_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACR4L_ARATH
• UniProt AC: Q9LX29
• Protein Name: Serine/threonine-protein kinase-like protein ACR4
• Gene Name: ACR4
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 895
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Endosome, multivesicular body membrane; Single-pass type I membrane protein. Also localized into protein export bodies. Internalization may be involved in degradation of ACR4 for its rapid turn-over
• Protein Description: Controls formative cell division in meristems, including root tips and lateral root initiation zones of the pericycle, in response to CLE40 signal. Acts with CLE40p peptide as a ligand-receptor pair in a signal transduction pathway, coordinating movement of the root tip and organization of cell divisions in the root meristem. Required during embryogenesis and development, probably for the differentiation of protoderm and epidermal cells. Involved in the regulation of cellular organization during the development of sepal margins and ovule integument outgrowth. Can phosphorylate ALE2..
• Protein Sequence: MRMFETRAREWILLVKLVLFTSIWQLASALGSMSSIAISYGEGGSVFCGLKSDGSHLVVCYGSNSAILYGTPGHLQFIGLTGGDGFMCGLLMLSHQPYCWGNSAFIQMGVPQPMTKGAEYLEVSAGDYHLCGLRKPIVGRRKNSNIISSSLVDCWGYNMTRNFVFDKQLHSLSAGSEFNCALSSKDKSVFCWGDENSSQVISLIPKEKKFQKIAAGGYHVCGILDGLESRVLCWGKSLEFEEEVTGTSTEEKILDLPPKEPLLAVVGGKFYACGIKRYDHSAVCWGFFVNRSTPAPTGIGFYDLAAGNYFTCGVLTGTSMSPVCWGLGFPASIPLAVSPGLCIDTPCPPGTHELSNQENSPCKFTGSHICLPCSTSCPPGMYQKSVCTERSDQVCVYNCSSCSSHDCSSNCSSSATSGGKEKGKFWSLQLPIATAEIGFALFLVAVVSITAALYIRYRLRNCRCSENDTRSSKDSAFTKDNGKIRPDLDELQKRRRARVFTYEELEKAADGFKEESIVGKGSFSCVYKGVLRDGTTVAVKRAIMSSDKQKNSNEFRTELDLLSRLNHAHLLSLLGYCEECGERLLVYEFMAHGSLHNHLHGKNKALKEQLDWVKRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEEHNARVADFGLSLLGPVDSGSPLAELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVLLLEILSGRKAIDMHYEEGNIVEWAVPLIKAGDINALLDPVLKHPSEIEALKRIVSVACKCVRMRGKDRPSMDKVTTALERALAQLMGNPSSEQPILPTEVVLGSSRMHKKSWRIGSKRSGSENTEFRGGSWITFPSVTSSQRRKSSASEGDVAEEEDEGRKQQEALRSLEEEIGPASPGQSLFLHHNF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
158	N-linked_Glycosylation	LVDCWGYNMTRNFVF HHCCCCCCCCCCEEH		-
196	N-linked_Glycosylation	VFCWGDENSSQVISL EEEECCCCCHHHEEE		-
290	N-linked_Glycosylation	VCWGFFVNRSTPAPT EEEEEEECCCCCCCC		-
398	N-linked_Glycosylation	SDQVCVYNCSSCSSH CCEEEEEECCCCCCC		-
410	N-linked_Glycosylation	SSHDCSSNCSSSATS CCCCCCCCCCCCCCC		-
475	Phosphorylation	DTRSSKDSAFTKDNG CCCCCCCCCCCCCCC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACR4L_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACR4L_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACR4L_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACR4L_ARATH	CR4	physical	18539132
ACR4L_ARATH	CR4	physical	23394827

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.