ACM2_HUMAN - dbPTM
ACM2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ACM2_HUMAN
UniProt AC P08172
Protein Name Muscarinic acetylcholine receptor M2
Gene Name CHRM2
Organism Homo sapiens (Human).
Sequence Length 466
Subcellular Localization Cell membrane
Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane
Multi-pass membrane protein . Phosphorylation in response to agonist binding promotes receptor internalization.
Protein Description The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol..
Protein Sequence MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2N-linked_Glycosylation------MNNSTNSSN
------CCCCCCCCC		51.682249995
2N-linked_Glycosylation------MNNSTNSSN
------CCCCCCCCC		51.682249995
3N-linked_Glycosylation-----MNNSTNSSNN
-----CCCCCCCCCC		49.242249995
3N-linked_Glycosylation-----MNNSTNSSNN
-----CCCCCCCCCC		49.242249995
6N-linked_Glycosylation--MNNSTNSSNNSLA
--CCCCCCCCCCCCC		43.172249995
6N-linked_Glycosylation--MNNSTNSSNNSLA
--CCCCCCCCCCCCC		43.172249995
9N-linked_GlycosylationNNSTNSSNNSLALTS
CCCCCCCCCCCCCCC		41.76UniProtKB CARBOHYD
177PhosphorylationTVEDGECYIQFFSNA
ECCCCCEEEEEECCC		8.0817525129
232PhosphorylationVANQDPVSPSLVQGR
CCCCCCCCHHHHCCE		17.7326657352
234PhosphorylationNQDPVSPSLVQGRIV
CCCCCCHHHHCCEEE		33.408132675
250PhosphorylationPNNNNMPSSDDGLEH
CCCCCCCCCCCCCCC		35.318132675
251PhosphorylationNNNNMPSSDDGLEHN
CCCCCCCCCCCCCCC		33.578132675
271PhosphorylationKAPRDPVTENCVQGE
CCCCCCCCCCCCCCC		27.208132675
282PhosphorylationVQGEEKESSNDSTSV
CCCCCCCCCCCCCCH		45.578132675
283PhosphorylationQGEEKESSNDSTSVS
CCCCCCCCCCCCCHH		45.838132675
286PhosphorylationEKESSNDSTSVSAVA
CCCCCCCCCCHHHHH		27.178132675
287PhosphorylationKESSNDSTSVSAVAS
CCCCCCCCCHHHHHH		35.698132675
288PhosphorylationESSNDSTSVSAVASN
CCCCCCCCHHHHHHC		20.308132675
290PhosphorylationSNDSTSVSAVASNMR
CCCCCCHHHHHHCCC		19.458132675
294PhosphorylationTSVSAVASNMRDDEI
CCHHHHHHCCCCCCC		25.268132675
302PhosphorylationNMRDDEITQDENTVS
CCCCCCCCCCCCCCC		28.118132675
307PhosphorylationEITQDENTVSTSLGH
CCCCCCCCCCHHCCC		17.498132675
309PhosphorylationTQDENTVSTSLGHSK
CCCCCCCCHHCCCCC		15.398132675
310PhosphorylationQDENTVSTSLGHSKD
CCCCCCCHHCCCCCC		24.518132675
311PhosphorylationDENTVSTSLGHSKDE
CCCCCCHHCCCCCCC		25.508132675
324S-palmitoylationDENSKQTCIRIGTKT
CCCCCCEEEEECCCC		1.5029575903
334PhosphorylationIGTKTPKSDSCTPTN
ECCCCCCCCCCCCCC		35.6423532336
423PhosphorylationCIPNTVWTIGYWLCY
CCCHHHHHHHHHHHH		10.5317525129
446PhosphorylationCYALCNATFKKTFKH
HHHHHHHHHHHHHHH		23.23-
450PhosphorylationCNATFKKTFKHLLMC
HHHHHHHHHHHHHHH		38.21-
457S-palmitoylationTFKHLLMCHYKNIGA
HHHHHHHHHHCCCCC		2.989143344
465PhosphorylationHYKNIGATR------
HHCCCCCCC------		31.53-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
232SPhosphorylationKinaseGRK-SUBFAMILY-GPS
232SPhosphorylationKinaseGRK_GROUP-PhosphoELM
232SPhosphorylationKinaseGRK2P25098
PSP
234SPhosphorylationKinaseGRK_GROUP-PhosphoELM
234SPhosphorylationKinaseGRK2P25098
PSP
234SPhosphorylationKinaseGRK-SUBFAMILY-GPS
250SPhosphorylationKinaseGRK-SUBFAMILY-GPS
250SPhosphorylationKinaseGRK2P25098
PSP
250SPhosphorylationKinaseGRK_GROUP-PhosphoELM
251SPhosphorylationKinaseGRK-SUBFAMILY-GPS
251SPhosphorylationKinaseGRK2P25098
PSP
251SPhosphorylationKinaseGRK_GROUP-PhosphoELM
271TPhosphorylationKinaseGRK_GROUP-PhosphoELM
271TPhosphorylationKinaseGRK2P25098
PSP
271TPhosphorylationKinaseGRK-SUBFAMILY-GPS
282SPhosphorylationKinaseGRK2P25098
PSP
282SPhosphorylationKinaseGRK_GROUP-PhosphoELM
282SPhosphorylationKinaseGRK-SUBFAMILY-GPS
283SPhosphorylationKinaseGRK2P25098
PSP
283SPhosphorylationKinaseGRK_GROUP-PhosphoELM
283SPhosphorylationKinaseGRK-SUBFAMILY-GPS
286SPhosphorylationKinaseGRK2P25098
PSP
286SPhosphorylationKinaseGRK_GROUP-PhosphoELM
286SPhosphorylationKinaseGRK-SUBFAMILY-GPS
287TPhosphorylationKinaseGRK_GROUP-PhosphoELM
287TPhosphorylationKinaseGRK2P25098
PSP
287TPhosphorylationKinaseGRK-SUBFAMILY-GPS
288SPhosphorylationKinaseGRK_GROUP-PhosphoELM
288SPhosphorylationKinaseGRK-SUBFAMILY-GPS
288SPhosphorylationKinaseGRK2P25098
PSP
290SPhosphorylationKinaseGRK_GROUP-PhosphoELM
290SPhosphorylationKinaseGRK-SUBFAMILY-GPS
290SPhosphorylationKinaseGRK2P25098
PSP
294SPhosphorylationKinaseGRK_GROUP-PhosphoELM
294SPhosphorylationKinaseGRK2P25098
PSP
294SPhosphorylationKinaseGRK-SUBFAMILY-GPS
302TPhosphorylationKinaseGRK_GROUP-PhosphoELM
302TPhosphorylationKinaseGRK-SUBFAMILY-GPS
302TPhosphorylationKinaseGRK2P25098
PSP
307TPhosphorylationKinaseGRK-SUBFAMILY-GPS
307TPhosphorylationKinaseGRK_GROUP-PhosphoELM
307TPhosphorylationKinaseGRK2P25098
PSP
309SPhosphorylationKinaseGRK-SUBFAMILY-GPS
309SPhosphorylationKinaseGRK_GROUP-PhosphoELM
309SPhosphorylationKinaseGRK2P25098
PSP
310TPhosphorylationKinaseGRK-SUBFAMILY-GPS
310TPhosphorylationKinaseGRK2P25098
PSP
310TPhosphorylationKinaseGRK_GROUP-PhosphoELM
311SPhosphorylationKinaseGRK-SUBFAMILY-GPS
311SPhosphorylationKinaseGRK2P25098
PSP
311SPhosphorylationKinaseGRK_GROUP-PhosphoELM
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ACM2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ACM2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SET_RATSetphysical
17065150
SET_HUMANSETphysical
17065150
GASP1_HUMANGPRASP1physical
15086532
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
608516Major depressive disorder (MDD)
Kegg Drug
D00113 Atropine (USP); Atropen (TN)
D00138 Scopolamine (INN); Transderm scop (TN)
D00147 Hyoscyamine (USP)
D00232 Methyloctatropine bromide (JAN); Anisotropine methylbromide (USAN); Octatropine methylbromide (INN);
D00270 Chlorpromazine (USP/INN); Thorazine (TN)
D00397 Tropicamide (JP16/USP/INN); Mydriacyl (TN)
D00465 Oxybutynin (USAN/INN); Anturol (TN); Oxytrol (TN)
D00481 Propantheline bromide (JP16/USP/INN); Pro-banthine (TN)
D00524 Carbachol (JAN/USP/INN); Miostat (TN)
D00525 Pilocarpine (JAN/USP); Ocusert pilo-20 (TN)
D00540 Glycopyrronium bromide (JAN/INN); Glycopyrrolate (USP); Robinul (TN); Seebri breezhaler (TN)
D00715 Hyoscine methobromide (INN); Methscopolamine bromide; Pamine (TN)
D00719 Hyoscyamine sulfate (USP); Hyoscyamine sulfate dihydrate; Egacene (TN)
D00720 Mepenzolate bromide (JP16/INN); Cantil (TN)
D00721 Methanthelinium bromide (INN); Methantheline bromide; Banthine (TN)
D00722 Oxybutynin hydrochloride (JAN); Oxybutynin chloride (USP); Ditropan (TN); Gelnique (TN)
D00723 Tridihexethyl chloride (BAN); Pathilon (TN)
D00774 Orphenadrine citrate (USP); Norflex (TN)
D00778 Benztropine mesilate (JAN); Benztropine mesylate (USP); Cogentin (TN)
D00779 Biperiden (JAN/USP/INN); Akineton (TN)
D00782 Procyclidine hydrochloride (USP); Kemadrin (TN)
D00787 Trihexyphenidyl hydrochloride (JP16/USP); Artane (TN)
D00789 Chlorpromazine hydrochloride (JP16/USP); Sonazine (TN)
D00999 Acetylcholine chloride (JP16/USP/INN); Miochol (TN)
D01000 Bethanechol chloride (JP16/USP); Urecholine (TN)
D01002 Cyclopentolate hydrochloride (JP16/USP); Cyclogyl (TN)
D01003 Hexocyclium metilsulfate (INN); Hexocyclium methyl sulfate; Tral (TN)
D01004 Homatropine hydrobromide (JP16/USP); Isopto homatropine (TN)
D01005 Isopropamide iodide (JAN/USP/INN); Darbid (TN)
D01007 Propiverine hydrochloride (JP16); Bup-4 (TN); Mictonorm (TN)
D01077 Atropine methonitrate (JAN/INN); Methylatropine nitrate (USAN); Ekomine (TN)
D01103 Trospium chloride (JAN/USAN/INN); Spasmex (TN); Spasmoplex (TN)
D01118 Profenamine hydrochloride (JAN); Ethopropazine hydrochloride; Parkin (TN); Parsidol (TN)
D01165 Piperidolate hydrochloride (JAN); Dactil (TN)
D01175 Carpronium chloride (JAN/INN); Actinamin (TN); Furozin (TN)
D01201 Tiemonium iodide (JAN/INN); Visceralgine (TN)
D01231 Piroheptine hydrochloride (JAN); Trimol (TN)
D01315 Methylbenactyzium bromide (JP16/INN)
D01359 Etomidoline (JAN/INN); Smedolin (TN)
D01377 Prifinium bromide (JAN/INN); Padrin (TN)
D01451 Scopolamine butylbromide (JP16); Butylscopolamine bromide; Buscopan (TN)
D01463 Diponium bromide (JAN/INN); Dipenine bromide
D01491 Butropium bromide (JP16/INN); Coliopan (TN)
D01500 Trimebutine maleate (JP16); Cerekinon (TN)
D01521 Pipethanate hydrochloride (JAN); Glymor (TN)
D01538 Valethamate bromide (JAN); Shinmetane (TN)
D01600 Diphenylpiperidinomethyldioxolan iodide (JAN); Anacolin; Gastrophyllin-A (TN)
D01648 Hyoscyamine methylbromide (JAN)
D01815 Oxapium iodide (JP16/INN); Espalexan (TN)
D01871 Metixene hydrochloride (JAN); Methixene hydrochloride (USAN); Methixene hydrochloride hydrete; Trest
D01875 Tiquizium bromide (JAN/INN); Thiaton (TN)
D01946 Oxitropium bromide (JAN/INN); Tersigan (TN)
D01955 Aclatonium napadisilate (JAN); Abovis (TN)
D01976 N-Methylscopolamine methylsulfate (JAN); Daipin (TN)
D01987 Pipethanate ethobromide (JAN); Panpurol (TN)
D02069 Atropine sulfate (JP16/USP); Isopto Atropine (TN)
D02070 Homatropine methylbromide (USP); Equipin (TN)
D02071 Scopolamine hydrobromide hydrate (JP16); Scopolamine hydrobromide (USP); Scopolamine hydrobromide tr
D02200 Pilocarpine hydrochloride (JP16/USP); Isopto carpine (TN); Pilopine HS (TN); Sanpilo (TN)
D02212 Ipratropium bromide hydrate (JP16); Ipratropium bromide (USAN); Atrovent (TN)
D02246 Biperiden hydrochloride (JP16/USP); Tasmolin (TN)
D02247 Biperiden lactate (JAN/USP); Tasmolin (TN)
D02417 Flutropium bromide (JAN); Flutropium bromide monohydrate; Flubron (TN)
D02535 Timepidium bromide hydrate (JP16); Sesden (TN)
D02599 Orphenadrine hydrochloride; Disipal (TN)
D02876 Alvameline maleate (USAN)
D03011 Atropine oxide hydrochloride (USAN); Genatropine hydrochloride
D03087 Benzetimide hydrochloride (USAN); Dioxatrine (TN)
D03264 Mazaticol hydrochloride hydrate (JAN); Mazaticol hydrochloride; Pentona (TN)
D03274 Chlorpromazine hibenzate (JAN); Contomin (TN)
D03276 Profenamine hibenzate (JAN); Parkin (TN)
D03711 Dexetimide (USAN/INN); (+)-Benzetimide
D03814 Atropine methylbromide (JAN)
D04034 Chlorpromazine phenolphthalinate (JAN); Wintermin (TN)
D04057 Esoxybutynin chloride (USAN)
D04087 Ethybenztropine (USAN); Etybenzatropine (INN); Panolid (TN)
D04116 Eucatropine hydrochloride (USP XXXII)
D04479 Hyoscyamine hydrobromide (USP)
D04970 Methacholine chloride (USAN/INN); Provocholine (TN)
D05035 Milameline hydrochloride (USAN)
D05478 Pilocarpine nitrate (USP); Pilagan (TN)
D05779 Sabcomeline hydrochloride (USAN)
D06015 Tazomeline citrate (USAN)
D06273 Imidafenacin (JAN/INN); Uritos (TN); Staybla (TN)
D07099 Cimetropium bromide (INN); Alginor (TN)
D07226 Fesoterodine (INN)
D07349 Choline alfoscerate (INN); Gliatilin (TN)
D07406 Pimethixene (INN); Calmixene (TN)
D07477 Atropine oxide (INN); Apitropin (TN)
D07511 Benzatropine (INN); Benztropine
D07513 Benzetimide (INN); Spasmental [veterinary] (TN)
D07759 Cyclopentolate (INN); Bell Pentolate (TN)
D07804 Dexetimide hydrochloride; Tremblex (TN)
D07951 Fentonium bromide (INN); Ulcesium (TN)
D08157 Mazaticol (INN)
D08209 Metixene (INN)
D08305 Orphenadrine (INN); Mialgin (TN)
D08376 Pilocarpine borate; pilolarpin ophtha (TN)
D08382 Piperidolate (INN)
D08384 Pipethanate (INN); Piperilate
D08395 Piroheptine (INN)
D08425 Procyclidine (INN)
D08426 Profenamine (INN)
D08441 Propiverine (INN)
D08595 Tiemonium methylsulfate; Visceralgine (TN)
D08638 Trihexyphenidyl (INN); Apo-trihex (TN)
D08639 Trimebutine (INN); Trimebutina (TN)
D08837 Aclidinium bromide (USAN/INN); Tudorza pressair (TN); Eklira genuair (TN)
D08923 Fesoterodine fumarate (JAN/USP); Toviaz (TN)
D09402 Darotropium bromide (USAN/INN)
D09752 Carpronium chloride hydrate (JAN)
D09819 Chlorpromazine tannate (JAN)
D10180 Umeclidinium (USAN)
D10181 Umeclidinium bromide (JAN/USAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ACM2_HUMAN

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