ACHE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACHE_HUMAN
• UniProt AC: Q04844
• Protein Name: Acetylcholine receptor subunit epsilon
• Gene Name: CHRNE
• Organism: Homo sapiens (Human).
• Sequence Length: 493
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
• Protein Description: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane..
• Protein Sequence: MARAPLGVLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGAYFNRVPDLPYAPCIQP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	ISLKVTLTNLISLNE EEEEEEHHEECCCCC	20.72	-
62	Phosphorylation	VTLTNLISLNEKEET EEHHEECCCCCCCCE	28.45	-
86	N-linked_Glycosylation	DWQDYRLNYSKDDFG CHHHHCCCCCCCCCC	29.99	UniProtKB CARBOHYD
161	N-linked_Glycosylation	YFPFDWQNCSLIFRS ECCCCCCCCEEEEEE	17.06	UniProtKB CARBOHYD
316	Phosphorylation	IFVMVVATLIVMNCV HHHHHHHHHHHHHCH	12.86	-
329	Phosphorylation	CVIVLNVSQRTPTTH CHHEEECCCCCCCCC	16.93	-
334	Phosphorylation	NVSQRTPTTHAMSPR ECCCCCCCCCCCCHH	30.51	27251275
335	Phosphorylation	VSQRTPTTHAMSPRL CCCCCCCCCCCCHHH	14.61	27251275
339	Phosphorylation	TPTTHAMSPRLRHVL CCCCCCCCHHHHHHH	13.98	27251275
356	Phosphorylation	LLPRLLGSPPPPEAP HHHHHHCCCCCCCCC	33.91	-
391	Phosphorylation	LILKKPRSELVFEGQ HHHHCCHHHCEECCC	43.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACHE_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACHE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACHE_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACHA_HUMAN	CHRNA1	physical	1712080

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.