ACHA5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACHA5_MOUSE
• UniProt AC: Q2MKA5
• Protein Name: Neuronal acetylcholine receptor subunit alpha-5
• Gene Name: Chrna5
• Organism: Mus musculus (Mouse).
• Sequence Length: 467
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
• Protein Description: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane..
• Protein Sequence: MAARGSRRRALRLLLMVQLLAGRWRPAGAARGARGGLPELSSAAKHEDSLFRDLFEDYEKWVRPVEHLSDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKIIRVPSDSLWIPDIVLFDNADGRFEGASTKTVVRYNGTVTWTQPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDRTDFFDNGEWEIMSAMGSKGNRTDSCCWYPCITYSFVIKRLPLFYTLFLIIPCIGLSFLTVVVFYLPSNEGEKISLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPWVRKIFLHKLPKLLCMRSHADRYFTQREEAEKDGGPKSRNTLEAALDCIRYITRHVVKENDVREVVEDWKFIAQVLDRMFLWTFLLVSIIGTLGLFVPVIYKWANIIVPVHIGNTIK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
75	Acetylation	LSDKIKIKFGLAISQ HCHHHHHCHHEHHHH	28.51	15621035
89	Acetylation	QLVDVDEKNQLMTTN HHCCCCHHCCEEEEE	45.59	15621045
155	N-linked_Glycosylation	TKTVVRYNGTVTWTQ CEEEEEECCEEEEEC	29.15	-
183	N-linked_Glycosylation	FFPFDLQNCSMKFGS EECCCCCCCEEEECE	27.42	-
229	N-linked_Glycosylation	SAMGSKGNRTDSCCW ECCCCCCCCCCCCCC	47.63	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACHA5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACHA5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACHA5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACHA4_MOUSE	Chrna4	physical	17434683
ACHA3_MOUSE	Chrna3	physical	17434683

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.