ACHA4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACHA4_MOUSE
• UniProt AC: O70174
• Protein Name: Neuronal acetylcholine receptor subunit alpha-4
• Gene Name: Chrna4
• Organism: Mus musculus (Mouse).
• Sequence Length: 629
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor.
• Protein Description: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions..
• Protein Sequence: MEIGGSGAPPPLLLLPLLLLLGTGLLPASSHIETRAHAEERLLKRLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPGDYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFYDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVSMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKVTLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPAWVRRVFLDIVPRLLFMKRPSVVKDNCRRLIESMHKMANAPRFWPEPESEPGILGDICNQGLSPAPTFCNRMDTAVETQPTCRSPSHKVPDLKTSEVEKASPCPSPGSCHPPNSSGAPVLIKARSLSVQHVPSSQEAAEGSIRCRSRSIQYCVSQDGAASLTESKPTGSPASLKTRPSQLPVSDQTSPCKCTCKEPSPVSPITVLKAGGTKAPPQHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	N-linked_Glycosylation	KWSRPVANISDVVLV CCCCCCCCCCHHHHH	34.23	-
109	N-linked_Glycosylation	WDPGDYENVTSIRIP CCCCCCCCCCEEECC	35.82	-
117	Phosphorylation	VTSIRIPSELIWRPD CCEEECCHHHEECCC	42.54	26643407
141	Phosphorylation	DFAVTHLTKAHLFYD CEEEEEECEEEEEEC	20.69	28542873
176	N-linked_Glycosylation	FFPFDQQNCTMKFGS EEECCCCCCEEEECE	20.00	-
180	Acetylation	DQQNCTMKFGSWTYD CCCCCEEEECEEECC	28.55	2396381
188	Acetylation	FGSWTYDKAKIDLVS ECEEECCHHHEEEEE	40.96	2396389
273	S-palmitoylation	VFYLPSECGEKVTLC HHHCCCCCCHHHHHH	11.35	-
361	Acetylation	VPRLLFMKRPSVVKD HHHHHHHCCCHHHHH	54.55	19857239
424	Phosphorylation	TAVETQPTCRSPSHK CCCCCCCCCCCCCCC	15.67	29899451
427	Phosphorylation	ETQPTCRSPSHKVPD CCCCCCCCCCCCCCC	32.66	25521595
429	Phosphorylation	QPTCRSPSHKVPDLK CCCCCCCCCCCCCCC	36.87	29899451
444	Phosphorylation	TSEVEKASPCPSPGS HHHCEECCCCCCCCC	37.80	29899451
448	Phosphorylation	EKASPCPSPGSCHPP EECCCCCCCCCCCCC	48.92	-
451	Phosphorylation	SPCPSPGSCHPPNSS CCCCCCCCCCCCCCC	16.79	29899451
468	Phosphorylation	PVLIKARSLSVQHVP CEEEEEEEEEEEECC	29.83	26643407
470	Phosphorylation	LIKARSLSVQHVPSS EEEEEEEEEEECCCC	22.45	26643407
476	Phosphorylation	LSVQHVPSSQEAAEG EEEEECCCCHHHHHC	43.49	26643407
477	Phosphorylation	SVQHVPSSQEAAEGS EEEECCCCHHHHHCC	26.43	26804993
489	Phosphorylation	EGSIRCRSRSIQYCV HCCEEEECCCEEEEE	33.72	29899451
491	Phosphorylation	SIRCRSRSIQYCVSQ CEEEECCCEEEEEEC	18.45	29899451
521	Phosphorylation	ASLKTRPSQLPVSDQ CCCCCCHHHCCCCCC	40.85	29899451
526	Phosphorylation	RPSQLPVSDQTSPCK CHHHCCCCCCCCCCC	23.28	19060867
529	Phosphorylation	QLPVSDQTSPCKCTC HCCCCCCCCCCCCEE	39.36	19060867
530	Phosphorylation	LPVSDQTSPCKCTCK CCCCCCCCCCCCEEC	23.75	19060867
535	Phosphorylation	QTSPCKCTCKEPSPV CCCCCCCEECCCCCC	16.47	26804993
540	Phosphorylation	KCTCKEPSPVSPITV CCEECCCCCCCCEEE	38.74	19060867
543	Phosphorylation	CKEPSPVSPITVLKA ECCCCCCCCEEEEEE	17.61	11434511
546	Phosphorylation	PSPVSPITVLKAGGT CCCCCCEEEEEECCC	24.14	26804993
563	Phosphorylation	PPQHLPLSPALTRAV CCCCCCCCHHHHHHH	13.24	22324799
567	Phosphorylation	LPLSPALTRAVEGVQ CCCCHHHHHHHHHHH	20.77	22324799

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACHA4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACHA4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACHA4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACHA5_MOUSE	Chrna5	physical	17434683

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.